A novel lysophosphatidic acid analog, LXR-1035, inhibits leukocyte- endothelium interaction via inhibition of cell adhesion molecules

Journal of Leukocyte Biology

Volumn 67, Issue 1, 2000, Pages 26-33

  Scalia, Rosario ^a   Pruefer, Diethard ^a   Lefer, Allan M ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Inflammation; Intravital microscopy; Microcirculation; P selectin

Indexed keywords

3 O OLEOYL 2 O METHYLGLYCERO 1 THIOPHOSPHATE; CD18 ANTIGEN; IMMUNOSUPPRESSIVE AGENT; LXR 1035; LYSOPHOSPHATIDIC ACID DERIVATIVE; N(G) NITROARGININE METHYL ESTER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; ENDOTHELIUM CELL; IMMUNOMODULATION; LEUKOCYTE ADHERENCE INHIBITION; LEUKOCYTE MIGRATION INHIBITION; MALE; MESENTERY BLOOD VESSEL; MICROCIRCULATION; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM;

ANIMALIA;

EID: 0033971071     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.67.1.26     Document Type: Article

References (31)

1. Umansky, S. R., Shapiro, J. P., Cuenco, G. M, Foehr, M. W., Bathurst, I. C., Tomei, L. D. (1997) Prevention of rat neonatal cardiomyocyte apoptosis induced by simulated in vitro ischemia and reperfusion. Cell Death Diff. 4, 608-616.
2. Umansky, S. R., Tomei, L. D. (1997) Apoptosis in the heart. Adv. Pharmacol. 41, 383-407.
3. Silver, M. J., Chetcuti, S. P., Mukherjee, D. B., Malycky, J. L., Tomei, L. D., Umansky, S., Nicolini, F. A. (1998) Use of a novel anti-apoptutic agent (LXR017) reduces infaret size following ischemia-reperfusion in the canine myocardium. J. Am. Call. Cardiol. 31, 66A.
4. Wu, G., Tomei, L. D., Bathurst, I. C., Zhang, F., Hong, C. B., Issel, C. J., Columbano, A., Salley, R. K., Chien, S. (1997) Antiapoptotic compound to enhance hypothermic liver preservation. Transplant. 63, 803-809.
5. Tsao, P. S., Lefer, A. M. (1990) Time course and mechanism of endothelial dysfunction in isolated ischemic- and hypoxic-perfused rat hearts. Am. J. Physiol. 259, H1660-H1666.
6. Kubers, P., Suzuki, M., Granger, D. N. (1991) Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc. Natl. Acad. Sci. USA 88, 4651-4655.
7. Lorant, D. E., Patel, K. D., McIntyre, T. M., McEver, R. P., Prescott, S. M., Zimmerman, G. A. (1991) Coexpressinn of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: a juxtacrine system for adhesion and activation of neutrophils. J. Cell Biol. 115, 223-234.
8. McEver, R. P., Beckstead, J. H., Moore, K. L., Marshall-Carlson, L., Bainton. D. F. (1989) GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. J. Clin. Invest. 84, 92-99.
9. Patel, K. D., Zimmerman, G. A., Prescott, S. M., McEver, R. P., McIntyre, T. M. (1991) Oxygen radicals induce human endothelial cells to express GMP-140 and bind neutrophils. J. Cell Biol. 112. 749-759.
10. Lorant, D. E., Topham, M. K., Whatley, R. E., McEver, R. P., McIntyre, T. M., Prescott, S. M., Zimmerman, G. A. (1993) Inflammatory roles of P-selectin. J. Clin. Invest. 92, 559-570.
11. Entman, M. I., Michael, L., Rossen, R. D., Dreyer, W. J., Anderson, D. C., Taylor, A. A., Smith, C. W. (1991) Inflammation in the course of early myocardial ischemia. FASEB J. 5, 2529-2537.
12. Lefer, A. M., Lefer, D. J. (1996) The role of nitric oxide and cell adhesion molecules on the microcirculation in ischenna-reperfusion. Cardiovasc. Res. 32, 743-751.
13. Davenpeck, K. L., Gauthier, T. W., Lefer, A. M. (1994) Inhibition of endothelial-derived nitric oxide promotes P-selectin expression and actions in the rat microcirculation. Gastroenterol. 107, 1050-1058.
14. Scalia, R., Lefer, A. M. (1998) In vivo regulation of PECAM-1 activity during acute endothelial dysfunction in the rat mesenteric microvasculature. J. Leukoc. Biol. 64, 163-169.
15. Scalia, R., Gefen, J., Petasis, N. A., Serhan, C. N., Lefer, A. M. (1997) Lipoxin A4 stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature: role of P-selectin. Proc. Natl. Acad. Sci. USA 94, 9967-9972.
16. Borders, J. L., Granger, H. J. (1984) An optical doppler intravital velocimeter. Microvasc. Res. 27, 117-127.
17. Granger, D. N., Benoit, J. N., Suzuki, M.,Grisham, M. B. (1989) Leukocyte adherence to venular endothelium during ischemia-reperfusion. Am. J. Physiol. 257, G683-G689.
18. Weyrich, A. S., Buerke, M., Albertine, K. H., Lefer, A. M. (1995) Time course of coronary vascular emlothelial adhesion molecule expression during reperfusion of the ischemic feline myocardium. J. Leukoc. Biol. 57, 45-55.
19. Vedder, N. B., Harlan, J. M. (1988) Increased surface expression of CD1 1b/CD18 (Mac-1) is not required for stimulated neutrophil adherence to cultured endothelium. J. Clin. Invest. 81, 676-682.
20. Williams, J. H. J., Moser, K. M., Ulich, T., Cairo, M. S. (1987) Harvesting the noncirculating pool of polymorphonuclear leukocytes in rats by hetastarch exchange transfusion (HET): yield and functional assessment. J. Leukoc. Biol. 42, 455-462.
21. Bevilacqua, M. P., Nelson, R. M. (1993) Endothelial-leukocyte adhesion molecules in inflammation and metastasis. Thromb. Haemost. 70, 152-154.
22. McEver, R. P. (1992) Leukocyte-endothelial cell interactions. CUIT. Opin. Cell Biol. 4, 840-849.
23. Davenpeck, K. L., Gauthier, T. W., Albertine, K. H., Lefer, A. M. (1994) Role of P-selectin in microvascular leukocyte-endothehal interaction in splanchnic ischemia-reperfusion. Am. J. Physiol. 267, H622-H630.
24. Butcher, E. C. (1991) Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 67, 1033-1036.
25. Vaporciyan, A. A., DeLisser, H. M., Yan, H. C., Mendiguren, I. I., Thom, S. R., Jones, M. L., Ward, P. A., Albelda, S. M. (1993) Involvement of platelet-endothehal cell adhesion molecule-1 in neutrophil recruitment in vivo. Science 262, 1580-1582.
26. Rubanyi, G. M., Vanhoutte, P. M. (1986) Oxygen-derived free radicals, endothelium, and responsiveness of vascular smooth muscle. Am. J. Physiol. 250, H815-H821.
27. Ma, X. L., Weyrich, A. S., Lefer, D. J., Lefer, A. M. (1993) Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium. Circ. Res. 72, 403-412.
28. Scalia, R., Armstead, V. E., Minchenko, A., Lefer, A. M. (1999) Essential role of P-selectin in the initiation of the inflammatory response induced by hemorrhage and reinfusion. J. Exp. Med. 189, 931-938.
29. Hakomori, S. (1981) Glycosphingolipids in cellular interaction, differentiation and oncogenesis. Annu. Rev. Biochem. 50, 733-764.
30. Okoshi, H., Hakomori, S., Nisar, M., Zhou, Q. H., Kimura, S., Tashiro, K., Igarashi, Y. (1991) Cell membrane signaling as target in cancer therapy. II: inhibitory effect of N,N,N-trimethylsphigosine on metastalic potential of murine B16 melanoma cell line through blocking of tumor cel-dependent platelet aggregation. Cancer Res. 51, 6019-6024.
31. Murohara, T., Scalia, K., Lefer, A. M. (1996) Lysophosphatidycholine promotes P-selectin expression in platelets and endothelial cells. Possible involvement of protein kinase C activation and its inhibition by nitric oxide donors. Circ. Res, 78, 780-789.