Gene-gene interaction between interleukin-6 and α2-macroglobulin influences the risk for Alzheimer's disease [4]

Annals of Neurology

Volumn 47, Issue 1, 2000, Pages 138-139

  Bagli, Metin ^a   Papassotiropoulos, Andreas ^a   Jessen, Frank ^a   Rao, Marie Luise ^a   Maier, Wolfgang ^a   Heun, Reinhard ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 MACROGLOBULIN; INTERLEUKIN 6;

ALZHEIMER DISEASE; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; ENZYME INHIBITION; GENE DELETION; GENE EXPRESSION; GENETIC SUSCEPTIBILITY; GENOTYPE; HYPOTHESIS; IMMUNE RESPONSE; LETTER; NERVE DEGENERATION; PATHOGENESIS; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; TANDEM REPEAT;

ALLELES; ALPHA-MACROGLOBULINS; ALZHEIMER DISEASE; GENE DELETION; GENES; HUMANS; INTERLEUKIN-6; ODDS RATIO;

EID: 0033970968     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8249(200001)47:1<138::AID-ANA28>3.0.CO;2-G     Document Type: Letter

References (4)

1. Papassotiropoulos A, Bagli M, Jessen F, et al. A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease. Ann Neurol 1999;45:666-668
2. Bauer J, Strauss S, Schreiter-Gasser U, et al. Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices. FEBS Lett 1991;285:111-114
3. Blacker D, Wilcox MA, Laird NM, et al. Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nat Genet 1998; 19:357-360
4. Rogaeva EA, Premkumar S, Grubber J, et al. An alpha-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease. Nat Genet 1999;22:19-21