The size and/or configuration of the cycloalkane D' ring in pentacyclic progesterone derivatives are crucial for their high-affinity binding to a protein in addition to progesterone receptor in rat uterine cytosol

Steroids

Volumn 65, Issue 3, 2000, Pages 163-170

  Smirnov, Alexander N ^a   Pokrovskaya, Elena V ^a   Kogteva, Galina S ^a   Shevchenko, Valery P ^b   Levina, Inna S ^c   Kulikova, Lidiya E ^c   Kamernitzky, Alexey V ^c  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b INSTITUTE OF MOLECULAR GENETICS   (Russian Federation)

^c N D ZELINSKY INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

Author keywords

Equilibrium constants; Progesterone 16 ,17 Cycloalkane derivatives; Progesterone receptor; Protein binding; Rat uterus

Indexed keywords

16ALPHA,17ALPHA CYCLOPROPANOPROGESTERONE; ANDROSTANOLONE; CORTICOSTERONE; CYCLOALKANE; CYCLOHEXANE DERIVATIVE; DEXAMETHASONE; DIETHYLSTILBESTROL; ESTRADIOL; METRIBOLONE; POLYCYCLIC HYDROCARBON; PROGESTERONE; PROGESTERONE DERIVATIVE; PROGESTERONE RECEPTOR; PROMEGESTONE; RADIOLIGAND; TESTOSTERONE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG CONFORMATION; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG STRUCTURE; FEMALE; LIVER; MALE; NONHUMAN; RAT; RECEPTOR AFFINITY; UTERUS;

ALKANES; ANIMALS; CHROMATOGRAPHY, GEL; CYTOSOL; DEXAMETHASONE; DIHYDROTESTOSTERONE; ESTRADIOL; FEMALE; MALE; PROGESTERONE; PROTEINS; RATS; RATS, WISTAR; RECEPTORS, ANDROGEN; RECEPTORS, ESTROGEN; RECEPTORS, GLUCOCORTICOID; RECEPTORS, PROGESTERONE; STRUCTURE-ACTIVITY RELATIONSHIP; UTERUS;

EID: 0033969215     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(99)00100-2     Document Type: Article

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