Myosin light chain kinase mediates sarcomere organization during cardiac hypertrophy in vitro

Nature Medicine

Volumn 6, Issue 2, 2000, Pages 183-188

  Aoki, Hiroki ^a   Sadoshima, Junichi ^b   Izumo, Seigo ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; CALCIUM ION; CALMODULIN; ENDOTHELIN 1; MYOSIN LIGHT CHAIN KINASE; PHENYLEPHRINE;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; MALE; NEWBORN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; SARCOMERE; SIGNAL TRANSDUCTION;

ANGIOTENSIN II; ANIMALS; CARDIOMEGALY; CELLS, CULTURED; MYOSIN-LIGHT-CHAIN KINASE; PHENOTYPE; PHENYLEPHRINE; PHOSPHORYLATION; RATS; RATS, WISTAR; SARCOMERES;

ANIMALIA;

EID: 0033967571     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/72287     Document Type: Article

References (45)

1. Katz, A.M. Cardiomyopathy of overload. A major determinant of prognosis in congestive heart failure. N. Engl. J. Med. 322, 100-110 (1990).
2. Braunwald, E. in Heart Disease. 4th edn Vol. 1 (ed. Braunwald, E.) 393 (W. B. Saunders, Philadelphia, PA, 1992).
3. Congestive heart failure in the United States: a new epidemic. National Heart, Lung, and Blood Institute Information Center, http://www.nhlbi.nih.gov/nhlbi/cardio/other/gp/CHF.htm. (1996)
4. Chien, K.R. et al. Transcriptional regulation during cardiac growth and development. Annu. Rev. Physiol. 55, 77-95 (1993).
5. Sadoshima, J. & Izumo, S. The cellular and molecular response of cardiac myocytes to mechanical stress. Annu. Rev. Physiol. 59, 551-571 (1997).
6. Epstein, H.F. & Fischman, D.A. Molecular analysis of protein assembly in muscle development. Science 251, 1039-1044 (1991).
7. Ridley, A.J. & Hall, A. The small CTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399 (1992).
8. Chihara, K. et al. Cytoskeletal rearrangements and transcriptional activation of c-fos serum response element by Rho-kinase. J. Biol. Chem. 272, 25121-25127 (1997).
9. Aoki, H., Izumo, S. & Sadoshima, J. Angiotensin II activates RhoA in cardiac myocytes - a critical role of RhoA in angiotensin II-induced premyofibril formation. Circ. Res. 82, 666-676 (1998).
10. Hoshijima, M., Sah, V.P., Wang, Y., Chien, K.R. & Brown, J.H. The low molecular weight CTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase. J. Biol. Chem. 273, 7725-7730 (1998).
11. Sadoshima, J., Jahn, L., Takahashi, T., Kulik, T.J. & Izumo, S. Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy. J. Biol. Chem. 267, 10551-10560(1992).
12. Simpson, P. Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response. J. Clin. Invest. 72, 732-738 (1983).
13. Clerk, A. & Sugden, P.M. Cell stress-induced phosphorylation of ATF2 and c-Jun transcription factors in rat ventricular myocytes. Biochem. J. 325, 801-810 (1997).
14. Heacock, C.S. & Bamburg, J.R. The quantitation of C- and F-actin in cultured cells. Anal Biochem. 135, 22-36 (1983).
15. Perrie, W.T. & Perry, S.V. An electrophoretic study of the low-molecular-weight components of myosin. Biochem. J. 119, 31-38 (1970).
16. Sweeney, H.L., Bowman, B.F. & Stull, J.T. Myosin light chain phosphorylation in vertebrate striated muscle: regulation and function. Am. J. Physiol. 264, C1085-1095 (1993).
17. 2+ transient in ferret ventricular muscles during hypoxia and acidosis. Am. J. Physiol. 269, C690-697 (1995).
18. 2+/calmodulin-dependent protein kinases. J. Biol. Chem. 273, 8951-8957 (1998).
19. Nakanishi, S., Yamada, K., Iwahashi, K., Kuroda, K. & Kase, H. KT5926, a potent and selective inhibitor of myosin light chain kinase. Mol. Pharmacol. 37, 482-488 (1990).
20. Sadoshima, J. & Izumo, S. Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro. Potential role of 70-kD 56 kinase in angiotensin II-induced cardiac hypertrophy. Circ. Res. 77, 1040-1052 (1995).
21. Callagher, P.J., Herring, B.P. & Stull, J.T. Myosin light chain kinases. J. Muscle. Res. Cell Motil. 18, 1-16 (1997).
22. Hu, Z.Y., Gong, Y.S. & Huang, W.L. Interaction of berbamine compound E6 and calmodulin-dependent myosin light chain kinase. Biochem. Pharmacol. 44, 1543-1547 (1992).
23. 2+ transient and contractile force induced by angiotensin II in aequorin-loaded rabbit ventricular myocardium. Cardiovasc Res 37, 524-531 (1998).
24. Blanchard, E.M., Smith, C.L., Allen, D.C. & Alpert, N.R. The effects of 2,3-butanedione monoxime on initial heat, tension, and aequorin light output of ferret papillary muscles. Pflugers Arch. 416, 219-221 (1990).
25. Thorburn, A. et al. HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy. J. Biol. Chem. 268, 2244-2249 (1993).
26. Pracyk, J.B. et al. A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy. J. Clin. Invest. 102, 929-937 (1998).
27. Wang, Y. et al. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. J. Biol. Chem. 273, 2161-2168 (1998).
28. Zechner, D., Thuerauf, D.J., Hanford, D.S., McDonough, P.M. & Glembotski, C.C. A role for the p38 mitogen-activated protein kinase pathway in myocardial cell growth, sarcomeric organization, and cardiac-specific gene expression. J. Cell Biol. 139, 115-127 (1997).
29. Wang, Y. et al. Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. J. Biol. Chem. 273, 5423-5426 (1998).
30. Sanbe, A. et al. Abnormal cardiac structure and function in mice expressing non-phosphorylatable cardiac regulatory myosin light chain 2. J. Biol. Chem. 274, 21085-21094 (1999).
31. Morano, I., Hofmann, F., Zimmer, M. & Ruegg, J.C. The influence of P-light chain phosphorylation by myosin light chain kinase on the calcium sensitivity of chemically skinned heart fibres. FEBS. Lett. 189, 221-224 (1985).
32. Sweeney, H.L. & Stull, J.T. Phosphorylation of myosin in permeabilized mammalian cardiac and skeletal muscle cells. Am. J. Physiol. 250, C657-660 (1986).
33. Ferrari, M.B., Ribbeck, K., Hagler, D.J. & Spitzer, N.C. A calcium signaling cascade essential for myosin thick filament assembly in Xenopus myocytes. J. Cell Biol. 141, 1349-1356 (1998).
34. Sweeney, H.L., Yang, Z., Zhi, G., Stull, J.T. & Trybus, K.M. Charge replacement near the phosphorylatable serine of the myosin regulatory light chain mimics aspects of phosphorylation. Proc. Natl. Acad. Sci. U. S A. 91, 1490-1494 (1994).
35. Small, J.V., Rottner, K. & Kaverina, I. Functional design in the actin cytoskeleton. Curr. Opin. Cell Biol. 11, 54-60 (1999).
36. 2+-dependent signaling, Circ. Res. 76, 1-15 (1995).
37. Eckel, J., Gerlach-Eskuchen, E. & Reinauer, H. Alpha-adrenoceptor-mediated increase in cytosolic free calcium in isolated cardiac myocytes. J. Mol. Cell. Cardiol. 23, 617-625 (1991).
38. Mebazaa, A. et al. Paracrine effects of endocardial endothelial cells on myocyte contraction mediated via endothelin. Am. J. Physiol. 265, H1841-1846 (1993).
39. Molkentin, J.D. et al. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell. 93, 215-228 (1998).
40. Rao, A., Luo, C. & Hogan, P.C. Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15, 707-747 (1997).
41. Gruver, C.L., DeMayo, F., Goldstein, M.A. & Means, A.R. Targeted developmental overexpression of calmodulin induces proliferative and hypertrophic growth of cardiomyocytes in transgenic mice. Endocrinology 133, 376-388 (1993).
42. Choukroun, G. et al. Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy. J. Clin. Invest. 102, 1311-1320(1998).
43. Kimura, K. et al. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273, 245-248 (1996).
44. Amano, M. et al. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J. Biol. Chem. 271, 20246-20249 (1996).
45. Kureishi, Y. et al. Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J. Biol. Chem. 272, 12257-12260 (1997),