Characterization of TEM-56, a novel β-lactamase produced by a Klebsiella pneumoniae clinical isolate

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 2, 2000, Pages 453-455

  Neuwirth, Catherine ^a   Labia, Roger ^b   Siebor, Eliane ^a   Pechinot, Andre ^a   Madec, Stephanie ^b   Chaibi, El Bachir ^b   Kazmierczak, Antoine ^a  

^a HÔPITAL DU BOCAGE   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; AZTREONAM; BETA LACTAMASE; CEFALORIDINE; CEFALOTIN; CEFOPERAZONE; CEFOTAXIME; CEFOXITIN; CEFTAZIDIME; CEFTRIAXONE; CEFUROXIME; CLAVULANIC ACID; ISOENZYME; PENICILLIN G; PIPERACILLIN; PROTEIN TEM 56; SULBACTAM; TAZOBACTAM; TICARCILLIN; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM ISOLATE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; ESCHERICHIA COLI; IC 50; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; STRAIN DIFFERENCE;

AMINO ACID SUBSTITUTION; BETA-LACTAMASES; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS;

EID: 0033966514     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.2.453-455.2000     Document Type: Article

References (27)

1. Ambler, R. P., A. F. W. Coulson, J. M. Frère, J. M. Ghuysen, B. Joris, M. Forsman, R. C. Levesque, G. Tirabi, and S. G. Waley. 1991. A standard numbering scheme for the class A β-lactamases. Biochem. J. 276:269-272.
2. Arlet, G., G. Brami, D. Deeré, A. Filippo, O. Gaillot, P. H. Lagrange, and A. Philippon. I995. Molecular characterisation by PCR-restriction fragment length polymorphism of TEM β-lactamases. FEMS Microbiol. Lett. 134: 203-208.
3. Arlet, G., S. Goussard, P. Courvalin, and A. Philippon. 1999. Sequences of the genes for the TEM-20, TEM-21, TEM-22, and TEM-29 extended-spectrum beta-lactamases. Antimicrob. Agents Chemother. 43:969-971.
4. Birnboim, H. C., and J. Doly. 1979. Rapid alkaline extraction procedure for screening recombinant piasmid DNA. Nucleic Acids Res. 7:1513-1523.
5. Cantu, C., III, W. Huang, and T. Palzkill. 1996. Selection and characterization of amino acid substitutions at residues 237-240 of TEM-1 β-lactamase with altered substrate specificity for aztreonam and ceftazidime. J. Biol. Chem. 271:22538-22545.
6. Chanal, C., M. C. Poupart, D. Sirot, R. Labia, J. Sirot, and R. Cluzel. 1992. Nucleotide sequences of CAZ-2, CAZ-6, and CAZ-7 β-lactamase genes. Antimicrob. Agents Chemother. 36:1817-1820.
7. Farzanen, S., E. B. Chaibi, J. Péduzzi, M. Barthélémy, R. Labia, J. Blazquez, and F. Baquero. 1996. Implication of Ile-69 and Thr-182 residues in kinetic characteristics of IRT-3 (TEM-32) β-lactamase. Antimicrob. Agents Chemother. 40:2434-2436.
8. Gouby, A., C. Neuwirth, G. Bourg, N. Bouzigues, M. J. Carles-Nurit, E. Despaux, and M. Ramuz. 1994. Epidemiological study by pulsed-field gel electrophoresis of an outbreak of extended-spectrum β-lactamase-producing Klebsiella pneumoniae in a geriatric hospital. J. Clin. Microbiol. 32:301-305.
9. T-2. Gene 102:71-73.
10. Heffron, F., B. J. McCarty, H. Ohtsubo, and E. Ohtsubo. 1979. DNA sequence analysis of the transposon tn3: three genes and three sites involved in transposition of tn3. Cell 18:1153-1163.
11. Jarlier, V., M. H. Nicolas, G. Fournier, and A. Philippon. 1988. Extended broad-spectrum β-lactam agents in Enterobacteriaceae: hospital prevalence and susceptibility patterns. Rev. Infect. Dis. 10:867-878.
12. Joris, B., P. Ledent, O. Dideberg, E. Fonzé, J. Lamotte-Brasseur, J. A. Kelly, J. M. Ghuysen, and J. M. Frère. 1991. Comparison of the sequences of class A β-lactamases and of the secondary structure elements of penicillin-recognizing proteins. Antimicrob. Agents Chemother. 35:2294-2301.
13. Labia, R., J. Andrillon, and F. Le Goffic. 1973. Computerized microacidimetric determination of beta-lactamase Michaelis-Menten constants. FEBS Lett. 33:42-44.
14. Labia, R., M. Barthélémy, and J. M. Masson. 1976. Multiplicité des β-lactamases: un problème d'isoenzymes? C. R. Acad. Sci. (Paris) 283D:1597-1600.
15. Lenfant, F., R. Labia, and J. M. Masson. 1991. Replacement of lysine 234 affects transition state stabilization in the active site of β-lactamase TEM1. J. Biol. Chem. 266:17187-17194.
16. Mabilat, C., and S. Goussard. 1993. PCR detection and identification of genes for extended-spectrum β-lactamases, p. 553-563. In D. H. Persing, T. F. Smith, F. C. Tenover, and T. J. White (ed.), Diagnostic molecular microbiology: principles and applications. American Society for Microbiology, Washington, D.C.
17. Neuwirth, C., E. Siébor, J. Lopez, A. Péchinot, and A. Kazmierczak. 1996. Outbreak of TEM-24-producing Enterobacter aerogenes in an intensive care unit and dissemination of the extended-spectrum β-lactamase to other members of the family Enterobacteriaceae. J. Clin. Microbiol. 34:76-79.
18. Palzkill, T., and D. Botstein. 1992. Identification of amino acid substitutions that alter the substrate specificity of TEM-1 β-lactamase. J. Bacteriol. 174: 5237-5243.
19. Péduzzi, J., A. Reynaud, P. Baron, M. Barthélémy, and R. Labia. 1994. Chromosomally encoded cephalosporinase of Proteus vuigaris Ro104 belongs to Ambler's class A. Biochim. Biophys. Acta 1207:31-39.
20. Petit, A., L. Maveyraud, F. Lenfant, J. P. Samama, R. Labia, and J. M. Masson. 1995. Multiple substitutions at position 104 of β-lactamase TEM-1: assessing the role of this residue in substrate specificity. Biochem. J. 305:33-40.
21. Saves, I., I. Burlet-Schilt, L. Maveyraud, J. P. Samama, J. C. Promé, and J. M. Masson. 1995. Mass spectral kinetic study of acylation and deacylation during the hydrolysis of penicillins and cefotaxime by β-lactamase TEM-1 and the G238S mutant. Biochemistry 34:11660-11667.
22. Sowek, J. A., S. B. Singer, S. Ohringer, M. F. Malley, T. J. Dougherty, J. Z. Gougoutas, and K. Bush. 1991. Substitution of lysine at position 104 or 240 of TEM-1 pTS18R β-lactamase enhances the effect of serine-164 substitution on hydrolysis or affinity for cephalosporins and the monobactam aztreonam, Biochemistry 30:3179-3188.
23. Sutcliffe, J. G. 1978. Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322. Proc. Natl. Acad. Sci. USA 8:3737-3741.
24. Tenover, F. C., R. D. Arbeit, R. V. Goering, P. A. Mickelsen, B. E. Murray, D. H. Persing, and B. Swaminathan. 1995. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J. Clin. Microbiol. 33:2233-2239.
25. Tessier, F., C. Arpin, A. Allery, and C. Quentin. 1998. Molecular characterization of a TEM-21 β-lactamase in a clinical isolate of Morganella morganii. Antimicrob. Agents Chemother. 42:2125-2127.
26. Venkatachalam, K. V., W. Huang, M. La Rocco, and T. Palzkill. 1994. Characterization of TEM-1 β-lactamase mutants from position 238 to 241 with increased catalytic efficiency for ceftazidime. J. Biol. Chem. 269:23444-23450.
27. Viadiu, H., J. Osuna, A. L. Fink, and X. Soberon. 1995. A new TEM β-lactamase double mutant with broadened specificity reveals substrate-dependent functional interactions. J. Biol. Chem. 270:781-787.