NKX2 gene expression in neuroectoderm but not in mesendodermally derived structures depends on sonic hedgehog in mouse embryos

Development Genes and Evolution

Volumn 210, Issue 1, 2000, Pages 47-50

  Pabst, Oliver ^a   Herbrand, Heike ^a   Takuma, Naoyuki ^b   Arnold, Hans Henning ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^b ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

Mouse development; NKX2 gene expression; Sonic hedgehog mutant

Indexed keywords

HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; DEVELOPMENTAL GENETICS; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO PATTERN FORMATION; ENDODERM; HEART; INTESTINE; MESODERM; MOUSE; MUTANT; NEUROECTODERM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ANIMALIA; ERINACEIDAE; EUKARYOTA; MAMMALIA; VERTEBRATA;

EID: 0033966374     PISSN: 0949944X     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00008188     Document Type: Article

References (15)

1. Barth KA, Wilson SW (1995) Expression of Zebrafish Nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain. Development 121:1755-1768
2. Biben C, Hatzistavrou T, Harvey RP (1998) Expression of NK-2 class homeobox gene NKX2.6 in foregut endoderm and heart. Mech Dev 73:125-127
3. Bober E, Franz T, Arnold HH, Gruss P, Tremblay P (1994) Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle precursor cells. Development 120:603-612
4. Briscoe J, Sussel L, Serup P, Hartigan-O'Connor D, Jessell TM, Rubenstein JL, Ericson J (1999) Homeobox gene NKX2.2 and specification of neuronal identity by graded Sonic hedgehog signaling. Nature 398:622-627
5. Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H, Beachy PA (1996) Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383: 407-413
6. Ericson J, Muhr J, Placzek M, Lints T, Jessel TM, Edlund T (1995) Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube. Cell 81:747-756
7. Guazzi S, Price M, DeFelice M, Damante G, Mattei MG, Di Lauro R (1990) Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity. EMBO J 9:3631-3639
8. Harvey R (1996) NK-2 homeobox genes and heart development. Dev Biol 178:203-216
9. Lints TJ, Parsons LM, Hartley L, Lyons I, Harvey RP (1993) NKX2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119:419-431
10. Litingtung Y, Lei L, Westphal H, Chiang C (1998) Sonic hedgehog is essential to foregut development. Nat Genet 20:58-61
11. Pabst O, Schneider A, Brand T, Arnold HH (1997) The mouse NKX2.3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development. Dev Dyn 209: 29-35
12. Pabst O, Herbrand H, Arnold HH (1998) NKX2.9 is a novel homeobox transcription factor which demarcates ventral domains in the developing mouse CNS. Mech Dev 73:85-93
13. Pera EM, Kessel M (1997) Patterning of the chick forebrain anlage by the prechordal plate. Development 124:4153-4162
14. Price M, Lazzaro D, Pohl T, Mattei MG, Rüther U, Olivio JC, Duboule D, Di Lauro R (1992) Regional expression of the homeobox gene NKX2.2 in the developing mammalian forebrain. Neuron 8:241-255
15. Roberts DJ, Smith DM, Goff DJ, Tabin CJ (1998) Epithelial-mesenchymal signaling during the regionalization of the chick gut. Development 125:2791-2801