Plasmodium falciparum clones resistant to (S)-9-(3-hydroxy-2- phosphonylmethoxy-propyl)adenine carry amino acid substitutions in DNA polymerase δ

Molecular and Biochemical Parasitology

Volumn 106, Issue 1, 2000, Pages 175-180

  Smeijsters, Louis J J W ^a   Zijlstra, Natasha M ^a   Veenstra, Jetty ^a   Verstrepen, Babs E ^a   Heuvel, Carine ^a   Overdulve, J Prosper ^a   De Vries, Erik ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

(S) HPMPA; 3' 5' exonuclease; DNA polymerase ; Mutant; Plasmodium falciparum; Resistance

Indexed keywords

9 (3 HYDROXY 2 PHOSPHONOMETHOXYPROPYL)ADENINE; ANTIMALARIAL AGENT; DNA DIRECTED DNA POLYMERASE DELTA;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; CELL DEATH; DNA REPLICATION; DRUG EFFECT; GENE MUTATION; GENOME; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ADENINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTIPARASITIC AGENTS; BINDING SITES; DNA-DIRECTED DNA POLYMERASE; DRUG RESISTANCE; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; PLASMODIUM FALCIPARUM; SEQUENCE ALIGNMENT; ULTRAVIOLET RAYS;

EID: 0033965313     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(99)00202-9     Document Type: Article

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