Effect on tumorigenicity and metastasis of transfection of a diploid benign rat mammary epithelial cell line with DNA corresponding to the mRNA for basic fibroblast growth factor

International Journal of Cancer

Volumn 65, Issue 1, 1996, Pages 104-111

  Davies, Barry R ^a,b   Fernig, David G ^a   Barraclough, Roger ^a   Rudland, Philip S ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; COMPLEMENTARY DNA; MESSENGER RNA;

ANIMAL CELL; ARTICLE; BREAST CELL; CARCINOGENICITY; CONTROLLED STUDY; GENETIC TRANSFECTION; GROWTH STIMULATION; METASTASIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; FEMALE; FIBROBLAST GROWTH FACTOR 2; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; NEOPLASM METASTASIS; RATS; RATS, INBRED WF; RECEPTORS, FIBROBLAST GROWTH FACTOR; RNA, MESSENGER; RNA, NEOPLASM; TRANSFECTION;

EID: 0030068116     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19960103)65:1<104::AID-IJC18>3.0.CO;2-G     Document Type: Article

References (22)

1. ANANDAPPA, S.Y., WINSTANLEY, J.H.R., LEINSTER, S., GREEN, B., RUDLAND, P.S. and BARRACLOUGH, R., Comparative expression of fibroblast growth factor mRNAs in benign and malignant breast disease. Brit. J. Cancer, 69, 772-776 (1993).
2. BARRACLOUGH, R., FERNIG, D.G., RUDLAND, P.S. and SMITH, J.A., Synthesis of basic fibroblast growth factor upon differentiation of rat mammary epithelial to myoepithelial-like cells in culture. J. cell. Physiol., 144, 333-344 (1990).
3. BLAM, S.B., MITCHELL, R., TISCHER, E., RUBIN, J.S., SILVA, M., SILVER, S., FIDDES, J.C, ABRAHAM, J.A. and AARONSON, S.A., Addition of growth hormone secretion signal to basic fibroblast growth factor results in cell transformation and secretion of aberrant forms of the protein. Oncogene, 3, 129-136 (1988).
4. DAMEN, J.E., GREENBERG, A.H. and WRIGHT, J.A., Transformation and amplification of the k-fgf proto-oncogene in NIH-3T3 cells, and inducation of metastatic potential. Biochim. biophys. Acta, 1097, 103-110 (1991).
5. DAVIES, B.R., BARRACLOUGH, R. and RUDLAND, P.S., Induction of metastatic ability in a stably diploid benign rat mammary epithelial cell line by transfection with DNA from human malignant breast carcinoma cell lines. Cancer Res., 54, 2785-2793 (1994).
6. DAVIES, B.R., DAVIES, M.P.A., GIBBS, F.E.M., BARRACLOUGH, R. and RUDLAND, P.S., Induction of the metastatic phenotype by transfection of a benign rat mammary epithelial cell line with the gene for p9Ka, a rat calcium-binding protein, but not with the oncogene EJ-ras-1. Oncogene, 8, 999-1008 (1993).
7. FERNIG, D.G., BARRACLOUGH, R., KE, Y.Q., WILKINSON, M.C., RUDLAND, P.S. and SMITH, J.A., Ectopic production of heparin-binding growth factors and receptors for basic fibroblast growth factor by rat mammary epithelial cell lines derived from malignant metastatic tumours. Int. J. Cancer, 54, 629-635 (1993).
8. FERNIG, D.G. and GALLAGHER, J.T., Fibroblast growth factors: an information network controlling tissue growth, morphogenesis and repair. Progr. Growth Factor Res., 5, 353-377 (1994).
9. FERNIG, D.G., SMITH, J.A. and RUDLAND, P.S., Appearance of basic fibroblast growth factor receptors upon differentiation of rat mammary epithelial to myoepithelial-like cells in culture. J. cell. Physiol., 142, 108-116 (1990).
10. GOMM, J.J., SMITH, J., RYALL, G.K., BAILLIE, R., TURNBULL, L. and COOMBES, R.C., Localization of basic fibroblast growth factor and transforming growth factor-beta-1 in the human mammary gland. Cancer Res., 51, 4685-4692 (1991).
11. JAMIESON, S., BARRACLOUGH, R. and RUDLAND, P.S., Transfection of a non-metastatic rat mammary epithelial cell line with the oncogenes for EJ-ras-1 and polyoma large T antigen. Int. J. Cancer, 46, 1071-1080 (1990).
12. JOUANNEAU, J., GAVRILOVIC, J., CARUELLE, D., JAYE, M., MOENS, G., CARUELLE, J.P. and THIERY, J.P., Secreted or nonsecreted forms of acidic fibroblast growth factor produced by transfected epithelial cells influence cell morphology, motility. and invasive potential. Proc. nat. Acad. Sci. (Wash.), 88, 2893-2897 (1991).
13. KE, Y.Q., FERNIG, D.G., WILKINSON, M.C., WINSTANLEY, J.H.R., SMITH, J.A., RUDLAND, P.S. and BARRACLOUGH, R., The expression of basic fibroblast growth factor and its receptor in cell lines derived from normal human mammary gland and a benign mammary lesion. J. Cell Sci., 106, 135-143 (1993).
14. MCLESKEY, S.W., KUREBAYASHI, J., HONIG, S.F., ZWIEBEL, J., LIPPMAN, M.E., DICKSON, R.B. and KERN, F.G., Fibroblast growth factor-4 transfection of MCF-7 cells produces cell lines that are tumorigenic and metastatic in ovariectomized or tamoxifen-treated athymic nude mice. Cancer Res., 53, 2168-2177 (1993).
15. MUNSON, P.J. and RODBARD, D., A versatile computerised approach for characterisation of ligand-binding systems. Anal. Biochem., 107, 220-239 (1980).
16. MURAKAMI, A., TANAKA, H. and MATSSUZAWA, A., Association of hst gene expression with metastatic phenotype in mouse mammary tumours. Cell Growth Differ., 1, 1-5 (1990).
17. PEYRAT, J.P., BONNETERRE, J., HONDERMARCK, H., HECQUET, B., ADENIS, A., LOUCHEZ, M.M., LEFEBVRE, J., BOILLY, B. and DEMAILLE, A., Basic fibroblast growth factor (bFGF) - mitogenic activity and binding sites in human breast cancer. J. Steroid Biochem. mol. Biol., 43, 87-94 (1992).
18. RADLER-POHL, A., POHL, J. and SCHIRRMACHER, V., Selective enhancement of metastatic capability in mouse bladder carcinoma cells after transfection with DNA from liver metastases of a human colon carcinoma. Int. J. Cancer, 41, 840-846 (1988).
19. RUDLAND, P.S., Stem cells and the development of mammary cancers in experimental rats and in humans. Cancer Metastasis Rev., 6, 55-83 (1987).
20. RUDLAND, P.S., PLATT-HIGGINS, A.M., WILKINSON, M.C. and FERNIG, D.G., Immunocytochemical identification of basic fibroblast growth factor in the developing rat mammary gland - variations in location are dependent on glandular structure and differentiation. J. Histochem. Cytochem., 41, 887-898 (1993).
21. SAMBROOK, J., FRITSCH, E.F. and MANIATIS, T., Molecular cloning: a laboratory manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY (1989).
22. WESTERMAN, R., JOHANNESEN, M., UNSICKER, K. and GROTHE, C., Basic fibroblast growth-factor (bFGF) immunoreactivity is present in chromaffin granules. J. Neurochem., 55, 285-292 (1990).