Tissue-specific regulation of IRS-2/PI 3-kinase association in aged rats

Biological Chemistry

Volumn 381, Issue 1, 2000, Pages 75-78

  Carvalho, Carla R O ^a   Maeda, Lucimara ^a   Brenelli, Sigisfredo L ^a   Saad, Mario J A ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Aging; Insulin action; Insulin receptor substrate 2; Insulin resistance; PI3 kinase; Tyrosine phosphorylation

Indexed keywords

GLUCOSE; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; LIVER PROTEIN; MUSCLE PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME REGULATION; GLUCOSE METABOLISM; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ANIMALIA;

EID: 0033964413     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2000.010     Document Type: Article

References (19)

1. Backer, J.M., Myers, M.G., Jr., Shoelson, S.E., Chin, D.J., Sun, X.J., Miralpeix, M., Hu, P., Margolis, B., Skolnik, E.Y., Schlessinger, J., and White, M.F. (1992). Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J. 11, 3469-3479.
2. Carvalho, C.R.O., Brenelli, S.L.B., Silva, A.C., Nunes, A.L.B., Velloso, L.A., and Saad, M.J.A. (1996). Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of rats. Endocrinology 137, 151-159.
3. Cheatham, B., and Khan, C.R. (1995). Insulin action and the insulin signaling network. Endocrinol. Rev. 16, 117-142.
4. Cheatham, B., Vlahos, C.J., Cheatham, L., Wang, L., Blenis, J., and Kahn, C.R. (1994). Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase DNA synthesis and glucose transporter translocation. Mol. Biol. Chem. 265, 396-400.
5. Cohen, P., Alessi, D.R., and Cross, D.A.E. (1997). PDK1, one of the missing links in insulin signaling transduction? FEBS Lett. 410, 3-10.
6. Downward, J. (1998). Lipid-regulated kinases: some common themes at last. Science 279, 673-674.
7. Ferrannini, E., Vichi, S., Beck-Nielsen, H., Laakso, M., Paolisso, G., and Smith, U. (1996). Insulin action and age. European Group for the study of insulin resistance (EGIR). Diabetes 45, 947-953.
8. Fink, R.I., Kolterman, O.G., Griffin, J., and Olefsky, J.M. (1983). Mechanisms of insulin resistance in aging. J. Clin. Invest. 71, 1523-1535.
9. Harari, Y.R., Tzahar, E., Nadiv, O., Rothenberg, P., Roberts, C.T., Jr., LeRoith, D., Yarden, Y., and Zick, Y. (1992). Insulin and Insulinomimetic agents induce activation of phosphatidylinositol 3′-kinase upon its association with pp185 (IRS-1) in intact rat livers. J. Biol. Chem. 267, 17483-17486.
10. Ivy, J.L., Young, J.C., Craig, B.W., Kohrt, W.M., and Holloszy, J.O. (1991). Ageing, exercise and food restriction: effects on skeletal muscle glucose uptake. Mech. Ageing Dev. 61, 123-133.
11. Kitamura, T., Ogawa, W., Sakaue, H., Hino, Y., Kuroda, K., Takata, M., Matsumoto, M., Maeda, T., Konishi, H., Kikkawa, U., and Kasuga, M. (1998). Requirement for activation of serine-theronine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport. Mol. Cell. Biol. 18, 3708-3717.
12. Klippel, A., Kavanaugh, W.M., Pot, D., and Williams, L.T. (1997). A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain. Mol. Cell. Biol. 17, 338-344.
13. Myers, M.G., Jr., and White, M.F. (1995). New frontiers in insulin receptor substrate signaling. Trends Endocrinol. Metab. 6, 209-215.
14. Myers, M.G., Jr., and White, M.F. (1996). Insulin signal transduction and the IRS proteins. Annu. Rer. Pharmacol. Toxicol. 36, 615-658.
15. Songyang, Z., Shoelson, S.E., Chaudhuri, M., Gish, G., Pawson, T., Haser, W.G., King, F., Roberts, F., Ratnofsky, S., Lechleider, R.J., Neel, B.G., Birge, R.B., Fajardo, J.E., Chow, M.M., Hanafusa, H., Shaffhausen, B., and Cantley, L.C. (1993). SH2 domains recognize specific phosphopeptide sequences. Cell 72, 767-778.
16. Sun, X.J., Rothenberg, P.L., Kahn, C.R., Backer, J.M., Araki, E., Wilden, P.A., Cahill, D.A., Goldstein, B.J., and White, M.F. (1991). The structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352, 73-77.
17. Sun, X.J., Wang, L.M., Zhang, Y., Yenush, L., Myers, M.G., Jr., Glasheen, E.M., Lane, W.S., Pierce, J.H., and White, M.F. (1995). Role of IRS-2 in insulin and cytokine signaling. Nature 377, 173-177.
18. Tanti, J.L., Grille, S., Gremeaux, T., Coffer, R.J., Van-Obberghen, E., and Le-Marchand-Brustel, Y. (1997). Potential role of protein kinase B in glucose transporter translocation in adipocytes. Endocrinology 138, 2005-2010.
19. Yoshimasa, Y., Yamada, K., Ida, T., Kakehi, T., and Imura, H. (1988). Change of insulin action with aging in conscious rats determined by euglycemic clamp. Am. J. Physiol. 254, E92-E98.