Fetal alcohol exposure alters serotonin transporter sites in rat brain

Brain Research

Volumn 856, Issue 1-2, 2000, Pages 184-192

  Zafar, Hannah ^a   Shelat, Suresh G ^a   Redei, Eva ^b   Tejani Butt, Shanaz ^a,c,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF THE SCIENCES   (United States)

^d UNIVERSITY OF THE SCIENCES   (United States)

Author keywords

Central nervous system; Female; Fetal alcohol exposure; Male; Quantitative autoradiography; Serotonin transporter site

Indexed keywords

CIANOPRAMINE; SEROTONIN TRANSPORTER;

ALCOHOL CONSUMPTION; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; BRAIN DEVELOPMENT; BRAIN REGION; CLINICAL TRIAL; FEMALE; FETAL ALCOHOL SYNDROME; HIPPOCAMPUS; MALE; MULTICENTER STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; SOMATOSENSORY CORTEX; ZONA INCERTA;

ALCOHOL DRINKING; ANALYSIS OF VARIANCE; ANIMALS; AUTORADIOGRAPHY; BRAIN; CARRIER PROTEINS; FEMALE; FETAL ALCOHOL SYNDROME; IMIPRAMINE; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; ORGAN SPECIFICITY; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL EXPOSURE DELAYED EFFECTS; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TRITIUM;

EID: 0033963432     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)02350-1     Document Type: Article

References (49)

1. A.R. Aitken, I. York, Early development of serotonin-containing neurons and pathways as seen in wholemount preparations of the fetal rat brain, J. Comp. Neurol. 274 (1988) 32-47.
2. B.C. Azmitia, P.M. Whitaker-Azmitia, Target cell stimulation of dissociated serotoninergic neurons in culture, Neuroscience 20 (1987) 47-63.
3. M.M. Bagheri, L. Burd, J.T. Martsolf, M.G. Klug, Fetal alcohol syndrome: maternal and neonatal characteristics, J. Perinat. Med. 26 (1998) 263-269.
4. D.E. Barnes, D.W. Walker, Prenatal ethanol exposure permanently reduces the number of pyramidal neurons in rat hippocampus, Dev. Brain Res. 1 (1981) 333-340.
5. R.D. Blakely, H.E. Berson, R.T. Fremeau, M.G. Caron, M.M. Peek, C.C. Bradley, Cloning and expression of functional serotonin transporter from rat brain, Nature 354 (1991) 66-70.
6. A.E. Calogero, G. Bagdy, K. Szemerdi, M.E. Tartaglia, P.W. Gold, G.P. Chrousos, Mechanisms of serotonin receptor agonist-induced activation of the hypothalamic-pituitary adrenal axis in the rat, Endocrinology 126 (1990) 1888-1894.
7. A.R. Chubakov, E.A. Gromova, G.V. Konavolov, E.F. Sarkisova, E.I. Chumasov, The effects of serotonin on the morphofunctional development of rat cerebral neocortex in tissue culture, Brain Res. 369 (1986) 285-297.
8. S.K. Clarren, D.W. Smith, The fetal alcohol syndrome, New Engl. J. Med. 298 (1978) 1063-1067.
9. M.J. Druse, L.H. Paul, Effect of in utero ethanol exposure on serotonin uptake in cortical regions, Alcohol 5 (1989) 455-459.
10. M.J. Druse, A. Kuo, N. Tajuddin, Efects of in utero ethanol exposure on the developing serotonergic system, Alcohol.: Clin. Exp. Res. 15 (1991) 678-684.
11. M.J. Druse, Effects of in utero ethanol exposure on the development of CNS neurotransmitter systems, in: M.W. Miller (Ed.), Development of the Central Nervous System, Effects of Alcohol and Opiates. Wiley-Liss, New York, 1992, pp. 139-167.
12. M.J. Druse, N.F. Tajuddin, J.D. Ricken, Effects of chronic ethanol consumption and aging on 5-HT2A receptors and 5-HT uptake sites, Alcohol.: Clin. Exp. Res. 21 (1997) 1157-1164.
13. J. Elis, M. Krsiak, N. Poschlova, Effect of alcohol given at different periods of gestation on brain serotonin in offspring, Activas Nerv. Sup. 20 (1978) 287-288.
14. M.I. Gonzalez, F. Farabollini, E. Albonetti, C.A. Wilson, Interactions between 5-hydroxytryptamine and testosterone in the control of sexual and nonsexual behavior in male and female rats, Pharmacol. Biochem. Behav. 47 (1994) 591-601.
15. P. Gregor, Murine serotonin transporter: sequence and localization to chromosome 11, Mamm. Genome 4 (1993) 283-284.
16. A. Heinz, J.D. Higley, J.G. Gorey, R.C. Saunders, D.W. Jones, D. Hommer, K. Zajicek, S.J. Soumi, K.P. Lesch, D.R. Weinberger, M. Linnoila, In vivo association between alcohol intoxication, aggression and serotonin transporter availability in nonhuman primates, Am. J. Psychiatry 155 (1998) 1023-1028.
17. A. Heinz, P. Ragan, D.W. Jones, D. Hommer, W. Williams, M.B. Knable, J.G. Gorey, L. Doty, C. Geyer, K.S. Lee, R. Coppola, D.R. Weinberger, M. Linnoila, Reduced central serotonin transporters in alcoholism, Am. J. Psychiatry 155 (1998) 1544-1549.
18. B.J. Huffman, E. Mezey, M.J. Brownstein, Cloning of a serotonin transporter affected by antidepressants, Science 254 (1991) 579-580.
19. K.L. Jones, D.W. Smith, C.N. Ulleland, A. Streissguth, Pattern of malformation in offspring of chronic alcoholic mothers, Lancet 1 (1973) 1267-1271.
20. S.J. Kelly, R.R. Dillingham, Sexually dimorphic effects of perinatal alcohol exposure on social interactions and amygdala DNA and DOPAC concentrations, Neurotoxol. Teratol. 16 (1994) 377-384.
21. J.A. Kim, M. Druse, Protective effects of maternal buspirone treatment on serotonin reuptake sites in ethanol-exposed offspring, Dev. Brain Res. 92 (1996) 190-198.
22. G.B. Kovachich, C.E. Aronson, D.J. Brunswick, A. Frazer, Quantitative autoradiography of serotonin uptake sites in rat brain using 3H-cyanoimipramine, Brain Res. 454 (1988) 78-88.
23. J.M. Lauder, J.A. Wallace, M.B. Wilke, A. DiNome, H. Krebs, Roles for serotonin in neurogenesis, Monogr. Neural Sci. 9 (1983) 3-10.
24. J.M. Lauder, Ontogeny of the serotoninergic system in the rat: serotonin as the developing signal, NY Acad. Sci. 600 (1990) 297-314.
25. J.M. Lauder, H. Krebs, Serotonin as a differentiation signal in early embryogenesis, Dev. Neurosci. 4 (1978) 291-295.
26. S.E. Maier, J.A. Miller, J.M. Blackwell, J.R. West, Fetal alcohol exposure and temporal vulnerability: regional differences in cell loss as a function of the timing of binge-like alcohol exposure during brain development, Alcohol.: Clin. Exp. Res. 23 (1999) 726-734.
27. R.F. McGivern, J. McGeary, S. Robeck, S. Cohen, R.J. Handa, Loss of reproductive competence at an earlier age in female rats exposed prenatally to ethanol, Alcohol.: Clin. Exp. Res. 19 (1995) 427-433.
28. J.A. Melo, J. Shendure, K. Pociask, L.M. Silver, Identification of sex-specific quantitative trait loci controlling alcohol preference in C57BL/6 mice, Nat. Genet. 13 (1996) 147-153.
29. M.W. Miller, G. Potempa, Numbers of neurons and glia in mature rat somatosensory cortex: effects of prenatal exposure to ethanol, J. Comp. Neurol. 293 (1990) 92-102.
30. J.M. Murphy, W.J. McBride, L. Lumeng, T.-K. Li, Contents of monoamines in forebrain regions of alcohol preferring and non-preferring lines of rats, Pharmacol. Biochem. Behav. 26 (1987) 389-392.
31. H.C. Olson, B.A. Morse, C. Huffine, Development and psychopathology: fetal alcohol syndrome and related conditions, Semin. Clin. Neuropsychiatry 3 (1998) 262-284.
32. G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates, Academic Press, New York, 1986.
33. M.R. Pranzatelli, J.M. Martens, Plasticity and ontogeny of the central 5-HT transporter: effect of neonatal 5,7-dihydroxytryptamine lesions in the rat, Dev. Brain Res. 70 (1992) 191-195.
34. W. Rathbun, M.J. Druse, Dopamine, serotonin, and acid metabolites in brain regions from the developing offspring of ethanol treated rats, J. Neurochem. 44 (1985) 57-62.
35. J.L. Rausch, M.G. Monteiro, M.A. Schuckit, Platelet serotonin uptake in men with family histories of alcoholism, Neuropsy-chopharmacology 4 (1991) 83-86.
36. E. Redei, I. Halasz, L.F. Li, M.B. Prystowsky, F. Aird, Maternal adrenalectomy alters the immune and endocrine functions of fetal alcohol-exposed male offspring, Endocrinology 133 (1993) 452-460.
37. P.D. Sampson, A.P. Streissguth, F.L. Bookstein, R.E. Little, S.K. darren, P. Dehaena, J.W. Hanson, J.M. Graham Jr., Incidence of fetal alcohol syndrome and prevalence of alcohol-related neurodevelopmental disorder, Teratology 56 (1997) 317-326.
38. M.A. Schuckit, A clinical model of genetic influence in alcohol dependence, J. Stud. Alcohol 55 (1994) 5-17.
39. P. Soubrie, Reconciling the role of central serotonin neurons in humans and animal behavior, Behav. Brain Sci. 9 (1986) 319-364.
40. H.W.M. Steinbusch, Distribution of serotonin immunoreactivity in the central nervous system of the rat cell bodies and terminals, Neuroscience 6 (1981) 557-618.
41. A.P. Streissguth, S. Landesman-Dwyer, J.C. Martin, D. Smith, Teratogenic effects of alcohol on human and laboratory animals, Science 209 (1980) 353-361.
42. A.P. Streissguth, J.M. Aase, S.K. Clarren, S.P. Randels, R.A. LaDue, D.F. Smith, Fetal alcohol syndrome in adolescents and adults, JAMA 265 (1991) 1961-1967.
43. N. Tajuddin, M.J. Druse, Chronic maternal ethanol consumption results in decreased serotoninergic 5-HT1 sites in cerebral cortical regions from offspring, Alcohol 5 (1989) 465-470.
44. S.M. Tejani-Butt, J. Yang, A. Kaviani, Time course of altered thyroid states on 5-HT1A receptors and 5-HT uptake sites in rat brain: an autoradiographic analysis, Neuroendocrinology 57 (1993) 1011-1018.
45. J. Weinberg, B. Zimmerberg, T.B. Sonderegger, Sex differences in effects of perinatal exposure to alcohol and other drugs, in: T.B. Sonderegger (Ed.), Perinatal Substance Abuse: Research Findings and Clinical Implications, Johns Hopkins Univ. Press, Baltimore, MD, 1992, pp. 51-89.
46. P.M. Whitaker-Azmitia, J.M. Lauder, A. Shemmer, Azmitia, Postnatal changes in serotonin receptors following prenatal alterations in serotonin levels: further evidence for functional fetal serotonin receptors, Dev. Brain Res. 33 (1987) 285-289.
47. P.M. Whitaker-Azmitia, M. Druse, P. Walker, J.M. Lauder, Serotonin as a developmental signal, Behav. Brain Res. 73 (1996) 19-29.
48. C.A. Wilson, I. Gonzalez, F. Farbollini, Behavioral effects in adulthood of neonatal manipulation of brain serotonin levels in normal and androgenized females, Pharmacol. Biochem. Behav. 41 (1991) 91-98.
49. F.C. Zhou, S. Bledsoe, L. Lumeng, T.-K. Li, Serotoninergic immunostained terminal fibers are decreased in selected brain areas of alcohol-preferring rats, Alcohol.: Clin. Exp. Res. 14 (1990) 355A.