Flurothyl-induced seizures in rats activate Fos in brainstem catecholaminergic neurons

Epilepsy Research

Volumn 39, Issue 1, 2000, Pages 1-12

  Silveira, D C ^a,b   Schachter, S C ^a   Schomer, D L ^a   Holmes, G L ^b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Autonomic centers; Brainstem; Epilepsy; Flurothyl; Fos; Rats; Seizures

Indexed keywords

DOPAMINE BETA MONOOXYGENASE; FLUROTHYL; PHENYLETHANOLAMINE N METHYLTRANSFERASE; PROTEIN C FOS;

ADRENERGIC NERVE CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTONOMIC NEUROPATHY; BRAIN SLICE; BRAIN STEM; CATECHOLAMINE NERVE CELL; CELL ACTIVATION; CONTROLLED STUDY; FEMALE; GRAND MAL SEIZURE; IMMUNOHISTOCHEMISTRY; LOCUS CERULEUS; MEDULLA OBLONGATA; NERVE CELL NETWORK; NONHUMAN; NORADRENERGIC NERVE; PONS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEIZURE;

ANIMALS; CONVULSANTS; DOPAMINE BETA-HYDROXYLASE; FEMALE; FLUROTHYL; MEDULLA OBLONGATA; NEURONS; PHENYLETHANOLAMINE N-METHYLTRANSFERASE; PONS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CATECHOLAMINE; SEIZURES;

EID: 0033958610     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(99)00106-0     Document Type: Article

References (69)

1. Blessing W.W., West M.J., Chalmers J.P. Hypertension, bradycardia and pulmonary oedema in the conscious rabbit after brain stem lesions coincinding with the A1 group of catecholamine neurons. Circulation Res. 49:1981;949-958.
2. Byrum C.E., Guynet P.G. Afferent and efferent connections of A5 noradrenergic cell group in the rat. J. Comp. Neurol. 261:1987;529-542.
3. Byrum C.E., Stornetta R., Guynet P.G. Electrophysiological properties of spinally-projecting A5 noradrenergic neurons. Brain Res. 303:1984;15-29.
4. Cassel M.D., Gray T.S. The amygdala directly innervates adrenergic (C1) neurons in the ventrolateral medulla in rat. Neurosci. Lett. 97:1989;163-168.
5. Cechetto D.F., Saper C.B. Neurochemical organization of the hypothalamic projection to the spinal cord in the rat. J. Comp. Neurol. 272:1988;579-604.
6. Cechetto D.F., Saper C.B. Role of the cerebral cortex in autonomic function. Loewy A.D., Spyer K.M. Central Regulation of Autonomic Functions. 1990;208-223 Oxford University Press, New York.
7. Chamberlin N.L., Saper C.B. A brainstem network mediating apneic reflexes in rats. J. Neurosci. 18:1998;6048-6056.
8. Cirillo J., Caverson M.M., Polosa C. Function of the ventrolateral medulla in the control of the circulation. Brain Res. Rev. 11:1986;359-391.
9. Clark M., Post R.M., Weiss S.R.B., Cain C.J., Nakajima T. Regional expression of c-fos mRNA in rat brain during the evolution of amygdala kindled seizures. Mol. Brain Res. 11:1991;55-64.
10. Contreras R.J., Beckstead R.M., Norgren R. The central projections of the trigeminal, facial, glossopharyngeal, and vagus nerves: an autoradiographic study in the rat. J. Auton. Nerv. Syst. 6:1982;303-322.
11. Dahlstrom A., Fuxe K. Evidence for the existence of monoamine containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brainstem neurons. Acta Physiol. Scand. 62(Suppl.):1964;1-55.
12. Dampney R.A.L., Goodchild A.K., Tan E. Vasomotor neurons in the rostral ventrolateral medulla of the rabbit. J. Auton. Nerv. Syst. 14:1985;239-254.
13. Devinsky O., Price B.H., Cohen S.I. Cardiac manifestations of complex partial seizures. Am. J. Med. 80:1986;195-202.
14. Doba N., Baresford H.R., Reis D.J. Changes in regional blood flow and cardiodynamics associated with electrically and chemically induced epilepsy in cats. Brain Res. 90:1975;115-132.
15. Dragunow M., Robertson H.A. Kindling stimulation induces c-fos protein(s) in granule cells of the rat dentate gyrus. Nature. 329:1987;441-442.
16. Elmquist J.K., Ackermann M.R., Register K.B., Rimler R.B., Ross L.R., Jacobson C.D. Induction of Fos-like immunoreactivity in the rat brain following Pasteurella multocida endotoxin administration. Endocrinology. 133:1993;3054-3057.
17. Freeman R., Schachter S.C. Autonomic epilepsy. Semin. Neurol. 15:1995;158-166.
18. Gebber G.L. Central determinants of sympathetic nerve discharge. Loewy A.E., Spyer K.M. Central Regulation of Autonomic Functions. 1990;126-144 Oxford University Press, New York.
19. Goodman J.H., Homan R.W., Crawford I.L. Kindled seizures elevate blood pressure and induce cardiac arrhythmias. Epilepsia. 31:1990;489-495.
20. Guyenet P.G. Role of the ventral medulla oblongata in blood pressure regulation. Loewy A.D., Spyer KM Central Regulation of Autonomic Functions. 1990;145-167 Oxford University Press, New York.
21. Healy B., Peck J., Healy M.R. The effect of amygdaloid kindling on heart period variability. Epilepsy Res. 21:1995;109-114.
22. Hochstenbach S.L., Ciriello J. Plasma hypernatremia induces c-fos activity in medullary catecholaminergic neurons. Brain Res. 674:1995;46-54.
23. Hokfelt T.K., Fuxe K., Goldstein M., Johansson O. Evidence for the existence of adrenaline neurons in the rat brain. Acta Physiol. Scand. 89:1973;286-288.
24. Holmes G.L, Chronopoulus A., Stafstrom C.E., Mikati M.A., Thurber S.J., Hyde P.A. et al. Effects of kindling on subsequent learning, memory, behavior, and seizure susceptibility. Brain Res. Dev. Brain. 73:1993;71-77.
25. Holmes G.L., Thurber S.J., Liu Z., Stafstrom C.E., Gatt A., Mikati M.A. Effects of quisqualic acid and glutamate on subsequent learning, emotionality, and seizure susceptibility in the immature and mature animal. Brain Res. 623:1993;325-328.
26. Jensen F.E., Firkusny I.R., Mower G.D. Differences in c-fos immunoreactivity due to age and mode of seizure induction. Mol. Brain Res. 17:1993;185-193.
27. Jimenez-Rivera C.A., Weiss G.K. The effect of amygdala kindled seizures on locus coeruleus activity. Brain Res. Bull. 22:1989;751-758.
28. Kalia M., Fuxe K., Goldstein M. Rat medulla oblongata. III. Adrenergic (C1 and C2) neurons, nerve fibers and presumptive terminal processes. J. Comp. Neurol. 233:1985;333-349.
29. Kalia M., Mesulam M.M. Brain stem projections of sensory and motor componets of the vagus complex in the cat: I. The cervical vagus and nodose ganglion. J. Comp. Neurol. 193:1980;435-465.
30. Kalia M., Mesulam M.M. Brain stem projections of sensory and motor componets of the vagus complex in the cat: II. Laryngeal, tracheobronchial, pulmonary, cardiac, and gastrointestinal branches. J. Comp. Neurol. 193:1980;467-508.
31. Kalia M., Sullivan J.M. Brainstem projections of sensory and motor components of the vagus nerve in the rat. J. Comp. Neurol. 211:1982;248-264.
32. Kanter R.K., Erickson J.T., Millhorn D.E. Activation of the c-fos gene in prodynorphin and proenkephalin-expressing cells of nucleus tractus solitarius after seizures. Exp. Neurol. 129:1994;290-298.
33. Kanter R.K., Strauss J.A., Sauro M.D. Seizure-induced c-fos expression in rat medulla oblongata is not dependent on associated elevation of blood pressure. Neurosci. Lett. 194:1995;201-204.
34. Labiner D.M., Butler L.S., Cao Z., Hosford D.A., Shin C., McNamara J.O. Induction of c-fos mRNA by kindled seizures: complex relationship with neuronal burst firing. J. Neurosci. 13:1993;744-751.
35. Lara J.P., Parkes M.J., Silva-Carchalo L., Izzo P., Dawid-Milner M.S., Spyer K.M. Cardiovascular and respiratory effects of stimulation of cell bodies of the parabrachial nuclei in the anesthetized rat. J. Physiol. 477:1994;321-329.
36. Loewy A.D., McKellar S., Saper C.B. Direct projections from the A5 catecholamine cell group to the intermediolateral cell column. Brain Res. 174:1979;309-314.
37. Marshall D.W., Westmoreland B.F., Sharbrough F.W. Ictal tachycardia during temporal lobe seizures. Mayo Clin. Proc. 58:1983;443-446.
38. Milner T.A., Morrison S.F., Abate C., Reis D.J. Phenylethanolamina N-methyltransferase containing terminals synapse directly on sympathetic preganglionic neurons in the rat. Brain Res. 448:1988;205-222.
39. Morgan J.I., Cohen D.R., Hempstead J.L., Curran T. Mapping patterns of c-fos expression in the central nervous system after seizure. Science. 237:1987;192-197.
40. Mosqueda-Garcia R. Central autonomic regulation. Robertson D., Low P.A., Polinsky R.J. Primer on the Autonomic Nervous System. 1996;3-28 Academic Press, California.
41. Otake K., Sasaki H., Mannen H., Enzure K. Morphology of expiratory neurons of the Botzinger complex: an HRP study in the cat. J. Comp. Neurol. 258:1987;565-579.
42. Paintal A.S. Vagal sensory receptors and their reflex effects. Physiol. Rev. 53:1973;159-227.
43. Papovici T., Represa A., Crepel V., Barbin G., Beaudoin M., Ben-Ari Y. Effects of kainic acid-induced seizures and ischemia on c-fos-like proteins in rat brain. Brain Res. 536:1990;183-194.
44. Paydarfar D., Eldridge F., Scott S., Dowell R., Wagner P. Respiratory responses to focal and generalized seizures in cats. Am. J. Physiol. 260:1991;R934-R940.
45. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1986;Academic Press, San Diego.
46. Pickel V.M., van Bockstaele E.J., Chan J., Cestari D.M. Amygdala efferents form inhibitory-type synapses with a subpopulation of catecholaminergic neurons in the rat's nucleus tractus solitarius. J. Comp. Neurol. 362:1995;510-523.
47. Piekut D.T., Pretel S., Applegate C.D. Activation of oxytocin-containing neurons of the paraventricular nucleus (PVN) following generalized seizures. Synapse. 23:1996;312-320.
48. Pierebone V.A., Aston-Jones G. Adrenergic innervation of the rat nucleus locus coeruleus arises from the C1 and C3 cell groups in the rostral medulla: An autonomic study combining retrograde transport and immunofluorescence. Neuroscience. 41:1991;525-542.
49. Price J.L., Amaral D.G. An autoradioghraphic study of the projections of the central nucleus of the monkey amygdala. J. Neurosci. 1:1981;1242-1259.
50. Pritchett E.L., McNamara J.O., Gallagher J.J. Arrythmogenic epilepsy: an hypothesis. Am. Heart J. 100:1980;683-688.
51. Reeves A.L., Nollet K.E., Klass D.W., Sharbrough F.W., So E.L. The ictal bradycardia syndrome. Epilepsia. 37:1996;983-987.
52. Reis D.J., Morrison S., Ruggiero D.A. The C1 area of the brainstem in tonic and reflex control of blood pressure. Hypertension. 11(Suppl. 1):1988;I8-I13.
53. Ricardo J.A., Koh E.T. Anatomical evidence of direct projections from the nucleus of the solitary tract to the hypothalamus, amygdala, and other forebrain structures in the rat. Brain Res. 153:1978;1-26.
54. Ross C.A., Ruggiero D.A., Joh T.H., Park D.H., Reis D.J. Rostral ventrolateral medulla: selective projections to the thoracic autonomic cell column from the region containing C1 adrenaline neurons. J. Comp. Neurol. 228:1984a;165-185.
55. Ross C.A., Ruggiero D.A., Park D.H., Joh T.H., Sved A.F., Fernandez-Pardal J. et al. Tonic vasomotor control by the rostral ventrolateral medulla:effect of electrical or chemical stimulation of the area containing adrenaline neurons on arterial pressure, heart rate and plasma catecholamines and vasopressin. J. Neurosci. 4:1984b;474-494.
56. Saper C.B. Convergence of autonomic and limbic connections in the insular cortex of the rat. J. Comp. Neurol. 210:1982;163-173.
57. Schwarzacher S.W., Wilhelm Z., Anders K., Richter D.W. The medullary respiratory network in the rat. J. Physiol. 435:1991;631-644.
58. Silveira D.C., Liu Z., Holmes G.L., Schomer D.L., Schachter S.C. Seizures in rats treated with kainic acid induce Fos-like immunoreactivity in locus coeruleus. NeuroReport. 9:1998;1353-1357.
59. Sved A.S., Mancini D.L., Graham J.C., Schreihofer A.M, Hoffman G.E. PNMT-containing neurons of C1 cell group express c-fos in response to changes in baroreceptor input. Am. Physiol. Soc. 266:1994;R361-R367.
60. Ter Horst G.L., de Boer P., Luiten P.G.M., van Willigen J.D. Ascending projections from the solitary tract nucleus to the hypothalamus: a Phaseoulus vulgaris lectin tracing study in the rat. Neuroscience. 31:1989;785-797.
61. Terreberry R.R., Neafsey E.J. Rat medial frontal cortex: a visceral motor region with a direct projection to the solitary nucleus. Brain Res. 278:1983;245-249.
62. Teskey G.C., Atkinson B.G., Cain D.P. Expression of proto-oncogene c-fos following electrical kindling in the rat. Mol. Brain Res. 11:1991;1-10.
63. Van Buren J. Some autonomic concomitants of ictal automatism: a study of temporal lobe attacks. Brain. 81:1958;505-528.
64. Van der Kooy D., Koda L.Y., McGinty J.F., Gerfen C.R., Bloom F.E. The organization of projections of the cortex, amygdala, and hypothalamus to the nucleus of the solitary tract in rat. J. Comp. Neurol. 224:1984;1-24.
65. Wannamaker B.B. Autonomic nervous system and epilepsy. Epilepsia. 26(Suppl. 1):1985;S31-S39.
66. White P.T., Grant P., Mosier J., Craig A. Changes in cerebral dynamics associated with seizures. Neurology. 11:1961;354-361.
67. Willete R.N., Krieger A.J., Barcas P.P., Sapru H.N. Medullary gamma-aminobutyric acid (GABA) receptors and the regulation of blood pressure in the rat. J. Pharmacol. Exp. Ther. 226:1983;893-899.
68. Willing A.E., Berthoud H-R. Gastric distension-induced Fos expression in catecholaminergic neurons of rat dorsal vagal complex. Am. Physiol. Soc. 272:1997;R59-R67.
69. Yamaguchi S., Rogawski M.A. Spike firing of single locus coeruleus neurons during experimental epileptic seizures in the rat. Soc. Neurosci. Abstr. 13:1987;912.