Activation of oxytocin-containing neurons of the paraventricular nucleus (PVN) following generalized seizures

Synapse

Volumn 23, Issue 4, 1996, Pages 312-320

  Piekut, D T ^a   Pretel, S ^a   Applegate, C D ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Epilepsy; Hypothalamus oxytocin; Kainate; Limbic kindling; Paraventricular nucleus; Seizures

Indexed keywords

KAINIC ACID; OXYTOCIN; PROTEIN C FOS;

ADAPTATION; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPLEX PARTIAL SEIZURE; CONTROLLED STUDY; ENTORHINAL CORTEX; GENE INDUCTION; GRAND MAL SEIZURE; HOMEOSTASIS; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; KINDLING; MALE; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; RAT; STRESS;

ANIMALS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; NERVE TISSUE PROTEINS; NEURONS; OXYTOCIN; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES;

EID: 0029832746     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199608)23:4<312::AID-SYN9>3.0.CO;2-A     Document Type: Article

References (62)

1. Angulo, J.A., Ledoux, M., and McEwen, B.S. (1991) Genomic effects of cold and isolation stress on magnocellular vasopressin mRNA-containing cells in the hypothalamus of the rat. J. Neurochem., 56:2033-2038.
2. Antoni, F.A. (1984) Novel ligand specificity of pituitary vasopressin receptors in the rat. Neuroendocrinology, 39:186-188.
3. Antoni, F.A. (1986a) Hypothalamic control of adenocorticotropic secretion: Advances since the discovery of 41-residue cortocotropin-releasing factor. Endocr. Rev., 7:351-378.
4. Antoni, F.A. (1986b) Oxytocin receptors in rat adenohypophysis: Evidence from radioligand binding studies. Endocrinology, 119: 2393-2395.
5. Antoni, F.A., Holmes, M.C., and Jones, M.T. (1983) Oxytocin as well as vasopressin potentiate ovine CRF in heterozygous and homozygous Brattleboro rats. Peptides, 4:411-415.
6. Antoni, F.A., Fink, G., and Sheward, W. J. (1990) Corticotrophin-releasing peptides in rat hypophysial portal blood after paraventricular lesions: A marked reduction in the concentration of corticotrophin-releasing factor-41, but no change in vasopressin. J. Endocrinol., 125:175-183.
7. Applegate, C.D., Flashman, L.A., and Burchfiel, J.L. (1986) The effects of chronic desmethylimipramine on entorhinal cortical kindling in rats. Brain Res., 398:121-127.
8. Ben-Ari, Y. (1985) Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy. Neuroscience, 14:375-403.
9. Bruhn, T.O., Sutton, S.W., Plotsky, P.M., and Vale, W.W. (1986) Central administration of corticotropin-releasing factor modulates oxytocin secretion in the rat. Endocrinology, 119:1558-1563.
10. Buijs, R.M. (1978) Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat. Pathways to the limbic system, medulla oblongata and spinal cord. Cell Tissue Res., 192:423-435.
11. Buijs, R.M., and Swaab, D.F. (1979) Immunoelectron microscopical demonstration of vasopressin and oxytocin in the limbic system of the rat. Cell Tissue Res., 204:355-356.
12. Buijs, R.M., and van Heerikhuize, J.J. (1982) Vasopressin and oxytocin release in the brain - A synaptic event. Brain Res., 252:71-76.
13. Buma, P., and Nieuwenhuys, R. (1988) Ultrastructural characterization of exocytotic release sites in different zones of the median eminence of the rat. Cell Tissue Res., 252:107-114.
14. Clark, M., Post, R.M., Weiss, S.R.B., Cain, C.J., and Nakajima, T. (1991) Regional expression of c-fos mRNA in rat brain during the evolution of amygdala kindled seizures. Mol. Brain Res., 11:55-64.
15. Curran, T., and Franza, B.R. (1988) Fos and jun: The AP-1 connection. Cell, 55:395-397.
16. Dragunow, M., Robertson, H.A., and Robertson, G.S. (1988) Amygdala kindling and c-fos protein(s). Exp. Neurol., 102:261-263.
17. Gibbs, D.M. (1984) Dissociation of oxytocin, vasopressin and corticotropin secretion during different types of stress. Life Sci., 35:487-491.
18. Gillies, G.E., Linton, E.A., and Lowry, P.J. (1982) Corticotropin releasing activity of the new CRF is potentiated several times by vasopressin. Nature, 299:355-357.
19. Greenwood, R.S., Meeker, R.B., Abdou, A., and Hayward, J.N. (1994) Kindled seizures induce a long-term increase in vasopressin mRNA. Mol. Brain Res., 24:20-26.
20. Herman, J.P., Schäfer, M.K.-H., Young, E.A., Thompson, R., Douglass, J., Akil, H., and Watson, S.J. (1989) Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis. J. Neurosci., 9:3072-3083.
21. Hisano, S., Li, S., Kagotani, Y., and Daikoku, S. (1992) Synaptic associations between oxytocin-containing magnocellular neurons containing corticotropin-releasing factor in the rat magnocellular paraventricular nucleus. Brain Res., 576:311-318.
22. Holmes, M.C., Antoni, F.A., Aguilera, G., and Catt, K.J. (1986) Magnocellular axons in passage through the median eminence release vasopressin. Nature, 319:326-329.
23. Ivell, R., and Richter, D. (1984) Structure and comparison of the oxytocin and vasopressin genes from rat. Proc. Natl. Acad. Sci. U.S.A., 81:2006-2010.
24. Jacobson, L., and Sapolsky, R. (1991) The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis. Endocr. Rev., 12:118-134.
25. Ježová, D., Michajlovskij, N., Kvetnansky, R., and Makara, G.B. (1993) Paraventricular and supraoptic nuclei of the hypothalamus are not equally important for oxytocin release during stress. Neuroendocrinology, 57:776-781.
26. Lang, R.E., Heil, J.W.E., Ganten, D., Hermann, K., Unger, T., and Rascher, W. (1983) Oxytocin, unlike vasopressin, is a stress hormone in the rat. Neuroendocrinology, 37:314-316.
27. Lightman, S.L., and Young, W.S., III (1987) Vasopressin, oxytocin, dynorphin, enkephalin and corticotrophin-releasing factor mRNA Stimulation in the rat. J. Physiol. (Lond.), 394:23-39.
28. Lutz-Bucher, B., and Koch, B. (1983) Characterization of specific receptors for vasopressin in the pituitary gland. Biochem. Biophys. Res. Commun., 115:492-493.
29. McIntyre, D.C. (1976) Adrenalectomy: Protection from kindled convulsion induced amnesia in rats. Physiol. Behav., 17:789-795.
30. McIntyre, D.C., and Wann, P.D. (1978) Adrenalectomy: Protection from kindled convulsion induced dissociation in rats. Physiol. Behav., 20:469-474.
31. Miaskowski, C., Ong, G.L., Lukic, D., and Haldar, J. (1988) Immobilization stress affects oxytocin and vasopressin levels in hypothalamic and extrahypothalamic sites. Brain Res., 458:137-141.
32. Morgan, J.I., and Curran, T. (1986) Role of ion flux in the control of c-fos expression. Nature, 322:552-555.
33. Morgan, J.I., Cohen, D.R., Hempstead, J.L., and Curran, T. (1987) Mapping patterns of c-fos expression in the central nervous system after seizure. Science, 237:192-197.
34. Nierenberg, J., Applegate, C.D., Burchfiel, J.L., and Piekut, D.T. (1994) Fos immunolabeling following kindled partial seizures elicited from different brain sites. Soc. Neurosci. Abstr., 20:1458.
35. Piekut, D.T., and Joseph, S.A. (1985) Relationship of CRF-immunostained cells and magnocellular neurons in the paraventricular nucleus of rat hypothalamus. Peptides, 6:873-882.
36. Piekut, D.T., and Joseph, S.A. (1986) Co-existence of CRF and vasopressin immunoreactivity in parvocellular paraventricular neurons of rat hypothalamus. Peptides, 7:891-898.
37. Piekut, D.T., Pretel, S., and Applegate, C.D. (1992) Identification of kindling activated neurons in the paraventricular nucleus. Soc. Neurosci. Abstr., 18:266.
38. Piekut, D.T, Pretel, S., and Applegate, C.D. (1993) Activation of neurons in PVN of hypothalamus following epileptic seizures. Soc. Neurosci. Abstr., 19:603.
39. Piekut, D.T., Phipps, B., Pretel, S., and Applegate, C.D. (1994) Activation of CRF-expressing neurons in hypothalamus following epileptic seizures. Soc. Neurosci. Abstr., 20:1458.
40. Plotsky, P., Bruhn, T., and Vale, W. (1985) Hypophysiotropic regulation of ACTH secretion in response to insulin-induced hypoglycemia. Endocrinology, 117:323-329.
41. Pow, D.V., and Morris, J.F. (1989) Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis. Neuroscience, 32:435-439.
42. Pretel, S., and Piekut, D.T. (1989) Mediation of changes in paraventricular vasopressin and oxytocin mRNA content to the medullary vagal complex and spinal cord of the rat. J. Chem. Neurol.,2:327-334.
43. Pretel, S., Applegate, C.D., and Piekut, D.T. (1995) Activation of somatostatin-synthesizing neurons in the hippocampal formation through kindling-induced seizures. Hippocampus, 5:40-51.
44. Racine, R.J. (1972) Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr. Clin. Neurophysiol., 32:281-294.
45. Rivier, C., and Vale, W. (1983) Interaction of corticotropin-releasing factor and arginine vasopressin on adrenocorticotropin secretion in vivo. Endocrinology, 113:939-942.
46. Sawchenko, L.E., Arias, C.A., and Mortrud, M.T. (1993) Local tetrodotoxin blocks chronic stress effects on corticotropin-releasing factor and vasopressin messenger ribonucleic acids in hypophysiotropic neurons. J. Neuroendocrinol., 5:341-348.
47. Sperk, G. (1994) Kainic acid seizures in the rat. Prog. Neurobiol., 42:1-32.
48. Stegner, H., Leake, R., Palmer, S., Oakes, G., and Fisher, D. (1984) The effect of hypoxia on neurohypophyseal hormone release in fetal and maternal sheep. Pediatr. Res., 18:188-191.
49. Suemaru, S., Hashimoto, K., Ogasa, T., Takao, T., Ota, Z., Hirakawa, M., and Kawata, M. (1990) Effects of hyperosmotic stimulation and adrenalectomy on vasopressin mRNA levels in the paraventricular and supraoptic nuclei of the hypothalamus: In situ hybridization histochemical analysis using a synthetic oligonucleotide probe. Acta Med. Okayama, 44:233-241.
50. Sun, Q., Pretel, S., Applegate, C.D., and Piekut, D. (1994) Long term up-regulation of oxytocin messenger RNA expression in rat PVN following kainic acid induced seizures. Soc. Neurosci. Abstr., 20:1457.
51. Sun, Q., Pretel, S., and Piekut, D. (1995) Oxytocin and vasopressin mRNA expression in rat hypothalamus following kainic acid induced seizures. Neuroscience, 71:543-554, 1996.
52. Swanson, L.W. (1991) Biochemical switching in hypothalamic circuits mediating responses to stress. Prog. Brain Res., 87:181-200.
53. Szafarczyk, A., Caracchini, M., Rondouin, G., Ixart, G., Malaval, F., and Assenmacher, I. (1986) Plasma ACTH and corticosterone responses to limbic kindling in the rat. Exp. Neurol., 92:583-590.
54. Tramu, G., Croix, C., and Pillez, A. (1983) Ability of the CRF immuno-reactive neurons of the paraventricular nucleus to produce a vasopressin-like material. Neuroendocrinology, 37:464-467.
55. Valiquette, G., Halder, J., Abrams, G.M., Nilaver, G., and Zimmerman, E.A. (1985) Extrahypothalamic neurohypophysial peptides in the rat central nervous system. Brain Res., 331:176-179.
56. Van Tol, H.H.M., Voorhuis, D.T.M., and Burbach, J.P.H. (1987) Oxytocin gene expression in discrete hypothalamic magnocellular cell groups is stimulated by prolonged salt loading. Endocrinology, 120:71-76.
57. White, J.D., and Gall, C.M. (1987) Differential regulation of neuropeptide and proto-oncogene mRNA content in the hippocampus following recurrent seizures. Mol. Brain Res., 3:21-29.
58. 14C-2-deoxyglucose uptake and fos immunocytochemistry. J. Neurosci., 13:4787-4809.
59. White, L.E., and Price, J.L. (1993b) The functional anatomy of limbic status epilepticus in the rat. II. The effects of focal deactivation. J. Neurosci., 13:4810-4830.
60. Wolfson, B., Manning, R.W., Davis, L.G., Acentzen, R., and Baldino, F., Jr. (1985) Co-localization of corticotropin releasing factor and vasopressin mRNA in neurons after adrenalectomy. Nature, 315:59-61.
61. Zimmerman, E.A., Nilaver, G., Hou-Yu, A., and Silverman, A.J. (1984) Vasopressinergic and oxytocinergic pathways in the central nervous system. Federation Proc., 43:91-96.
62. Zingg, H.H., Lefebvre, D., and Almazan, G. (1986) Regulation of vasopressin gene expression in rat hypothalamic neurons, response to osmotic stimulation. J. Biol. Chem., 261:12956-12959.