Melatonin reduces the increase in 8-hydroxy-deoxyguanosine levels in the brain and liver of kainic acid treated rats

Molecular and Cellular Biochemistry

Volumn 178, Issue 1-2, 1998, Pages 299-303

  Tang, Lei ^a   Reiter, Russel J ^a   Li, Zhong Ren ^a   Ortiz, Genaro G ^a   Yu, Byung Pal ^a   Garcia, Joaquin J ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

8 hydroxy deoxyguanosine; Free radical; Kainic acid; Melatonin

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; DNA; KAINIC ACID; MELATONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DNA DAMAGE; FRONTAL CORTEX; HIPPOCAMPUS; LIVER; MALE; NONHUMAN; RAT;

ANIMALS; ANTIOXIDANTS; BRAIN; DEOXYGUANOSINE; DNA DAMAGE; KAINIC ACID; LIVER; MALE; MELATONIN; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0031910656     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006815530519     Document Type: Article

References (45)

1. Cheng Y, Sun AY: Oxidative mechanisms involved in kainate-induced cytotoxicity in cortical neurons. Neurochem Res 19: 1557-1564, 1994
2. Ben-Ari Y, Tremblay E, Ottersen OP, Naquet R: Evidence suggesting secondary epileptogenic lesion after kainic acid: pretreatment with diazepam reduces distant but not local damage. Brain Res 165: 362-365, 1979
3. Dutrait N, Culcasi M, Cazevieille C, Pietri S, Tordo P, Bonne C, Muller A: Calcium-dependent free radical generation in cultured retinal generation in cultured retinal neurons injured by kainate. Neurosci Lett 198: 13-16, 1995
4. Reiter FJ: Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J 9: 526-533, 1995
5. Reiter RJ: Functional pleiotropy of the neurohormone melatonin: Antioxidant protection and neuroendocrine regulation. Front Neuroendocrinol 16: 383-415, 1995
6. Pellegrini-Giampietro DE, Cherici G, Alesiani M, Caria V, Moroni F: Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage. J Neurosci 10: 1035-1041, 1990
7. Melchiorri D, Reiter RJ, Sewerynek E, Chen LD, Nistico G: Melatonin reduces kainate induced lipid peroxidation in homogenates of different brain regions. FASEB J 9: 1205-1210, 1995
8. Reiter RJ: Pineal melatonin: Cell biology of its synthesis and of its physiological interactions. Endocrine Rev 12: 151-180, 1991
9. Reiter RJ, Melchiorri D, Sewerynek E, Poeggeler B, Barlow-Walden LR, Chuang JI, Ortiz GO, Acuna-Castroviejo D: A review of the evidence supporting melatonin's role as an antioxidant. J Pineal Res 18: 1-11, 1995
10. Costa EJX, Lopes RH, Lamy-Freund MT: Permeability of pure lipid bilayers to melatonin. J Pineal Res 19: 123-124, 1995
11. Shida CS, Castrucci AML, Lamy-Freund MT: High melatonin solubility in aqueous medium. J Pineal Res 16: 198-201, 1994
12. Kasai H, Nishimura S: Formation of 8-hydroxydeoxyguanosine in DNA by oxygen radicals and its biological significance. In: H Sies (ed). Oxidative Stress: Oxidants and Antioxidants. Academic Press, London, 1991, pp 99-116
13. Shigenaga MK, Aboujaoude EN, Chen Q, Ames BN: Assays of oxidative DNA damage biomarkers 8-oxo-2 -deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid cinematography with electrochemical detection. Meth Enzymol 234: 16-33, 1994
14. Floyd RA, Waston JJ, Harris J, West M, Wong PK: Formation of 8-hydroxydeoxyguanosine, hydroxyl free radical adduct of DNA in granulocytes exposed to the tumor promoter, tetradecanoylphorbolacetate. Biochem Biophys Res Commun 137: 841-846, 1986
15. Shibutani S, Takeshita M, Grollman AP: Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature 349: 431-434, 1991
16. Wood ML, Dizdaroglu M, Gajewski E, Essigmann JM: Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome. Biochemistry 29: 7024-7032, 1990
17. Cheng KC, Cahill H, Kasai H, Nishimura S, Loeb LA: 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G→T and A→C substitutions. J Biol Chem 267: 166-172, 1992
18. Kaneko T, Tahara S, Matsuo M: Non-linear accumulation of 8-hydroxy-2 -deoxyguanosine,a marker of oxidized DNA damage, during aging. Mutation Res 316: 277-285, 1996
19. Nagashima M, Kasai H, Yokota J, Nagamachi Y, Ichinose T, Sagai M: Formation of an oxidative DNA damage 8-hydroxydeoxyguanosine, in mouse lung DNA after intratracheal instillation of diesel exhaust particles and effects of high dietary fat and betacarotene on this process. Carcinogenesis 16: 1441-1445, 1995
20. Ogura H, Takeuchi T, Morimoto K: A comparison of the 8-hydroxydeoxyguanosine, chromosome aberrations and micronucleus techniques for the assessment of the genotoxicity of mercury compounds in human blood lymphocytes. Mutat Res 340: 175-182, 1996.
21. Filipkowski RK, Hetman M, Kaminska B, Kaczmarek L: DNA fragmentation in rat brain after intraperitoneal administration of kainate. NeuroReport 5: 1538-1540, 1994
22. Giusti P, Lipartiti M, Franceschini D, Schiavo N, Floreani M, Manev H: Neuroprotection by melatonin from kainate-induced excitotoxicity in rats. FASEB J 10: 891-896, 1996
23. 2+ dependent. NeuroReport 5: 1477-1480, 1994
24. Cramer CL, Stagnitto ML, Knowles MA, Palmer GC: Kainic acid and 4-aminopyridine seizure modles in mice: evaluation of efficacy of anti-epileptic agents and calcium antagonists. Life Sci 54: PL 271-275, 1994
25. Kontos HA, Wei EP, Povlishock TJ, Dietrich WD, Margiera CJ, Ellis EF: Cerebral arteriolar damage by arachidonic acid and prostaglandin G2. Science 209: 1242-1244, 1980
26. Lynch MA, Bliss TVP: Long term potentiation of synaptic transmission in the hippocampus of the rat; effect of calmodulin and oleoyl-acetyl-glycerol on release of 3H-glutamate. Neurosci Lett 65: 171-176, 1986
27. 2+ induced by excitatory amino acid in CA1 hippocampus neurons. Science 240: 649-653, 1988
28. Culcasi M, Lafon-Cazal M, Pietri S, Bockaert J: Glutamate receptors induce a burst of superoxide via activation of nitric oxide synthase in arginine-depleted neurons. J Biol Chem 17: 12589-12593, 1994
29. Dawson VL, Dawson TM, London ED, Bredt DS, Synder SH: Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci USA 88: 6368-6371, 1991
30. Cazevieille C, Muller A, Meynier F, Bonne C: Superoxide and nitric oxide cooperation in hypoxia/reoxygenation-induced neuron injury. Free Rad Biol Med 14: 389-395, 1993
31. Pozo D, Reiter RJ, Calvo JR, Guerrero JM: Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum. Life Sci 55: PL 455-460, 1994
32. Bettahi I, Pozo D, Osuna C, Reiter RJ, Acuna-Castroviejo D, Guerrero JM: Melatonin reduces nitric oxide synthase activity in rat hypothalamus. J Pineal Res 20: 205-210, 1996
33. 3H-melatonin to calmodulin. Life Sci 53: 201-207, 1993
34. Tan DX, Chen LD, Poeggeler B, Manchester LC, Reiter RJ: Melatonin: A potent, endogenous hydroxyl radical scavenger. Endocrine J 1: 57-60, 1993
35. Tan DX, Poeggeler B, Reiter RJ, Chen LD, Chen S, Manchester LC, Barlow-Walden LR: The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen salfrole in vivo. Cancer Lett 70: 65-70, 1993
36. Tan DX, Reiter RJ, Chen LD, Poeggeler B, Manchester LC, Barlow-Walden LR: Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole. Carcinogenesis 15: 215-218, 1994
37. Reiter RJ: Antioxidant actions of melatonin. Adv Pharmacol 38: 103-117, 1997
38. Antolin I, Rodriguez C, Sainz RM, Mayo JC, Uria H, Kotler ML, Rodriguez-Colunga MJ, Tolivia D, Menendez-Pelaez A: Neurohormone melatonin prevents cell damage: effect on gene expression for antioxidant enzymes. FASEB J 10: 882-890, 1996
39. Barlow-Walden LR, Reiter RJ, Pablos M, Menendez-Pelaez A, Chen LD, Poeggler B: Melatonin stimulates brain glutathione peroxidase activity. Neurochem Int 24: 497-502, 1995
40. Singal PK, Dhalla AK, Hill M, Thomas TP: Endogenous antioxidant changes in the myocardium in response to acute and chronic stress conditions. Mol Cell Biochem 129: 179-186, 1993
41. Davies KJA, Quintanilha T, Brooks GA, Packer L: Free radicals end tissue damage produced by exercise. Biochem Biophys Res Commun 107: 1178-1205, 1982
42. Kumar CT, Reddy VK, Prasad M, Thyagaraju K, Reddanna P: Dietary supplementation of vitamin E protects heart tissue from exercise induced oxidant stress. Mol Cell Biochem 111: 109-115, 1992
43. Hara M, Abe M, Suzuki T, Reiter RJ: Tissue changes in glutathione metabolism and lipid peroxidation induced by swimming are partially prevented by melatonin. Pharmacol Toxicol 78: 308-312, 1996
44. Menendez-Pelaez A, Reiter RJ: Distribution of melatonin in mammalian tissues: The relative importance of nuclear versus cytosolic localization. J Pineal Res 15: 59-69, 1993
45. Giusti P, Gusella M, Lipartiti M, Milani D, Zhu W, Vicini S, Manev H: Melatonin protects primary cultures of cerebellar granule neurons from kianate but not from N-methyl-D-aspartate excitotoxicity. Exp Neurol 131: 39-46, 1995