Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: Analysis of instances of therapeutic misadventure

Hepatology

Volumn 22, Issue 3, 1995, Pages 767-773

  Zimmerman, Hyman J ^a   Maddrey, Willis C ^b  

^a ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450; GLUTATHIONE; PARACETAMOL;

ADULT; ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; DOSE RESPONSE; DRUG ALCOHOL INTERACTION; DRUG GLUCURONIDATION; ENZYME BINDING; FEMALE; GASTROINTESTINAL SYMPTOM; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; PAIN; PRIORITY JOURNAL; UREMIA;

ACETAMINOPHEN; ADULT; ALCOHOLISM; ASPARTATE AMINOTRANSFERASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FEMALE; HUMAN; LIVER; MALE; MIDDLE AGE;

EID: 0029083319     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1016/0270-9139(95)90295-3     Document Type: Article

References (83)

1. Acute liver necrosis following overdoses of paracetamol
2. Liver damage and impaired glucose tolerance after paracetamol overdoses
3. Acetaminophen hepatotoxicity
4. Chronic excessive acetaminophen use and liver damage
5. Hepatotoxicity of paracetamol enhanced by ingestion of alcohol
6. Liver damage after paracetamol
7. Concomitant alcohol and drug abuse enhancing acetaminophen toxicity
8. Acetaminophen associated hepatic injury
9. Increased hepatotoxicity of acetaminophen in the alcoholic
10. Apparent potential of acetaminophen toxicity by alcohol
11. Potentiation of acetaminophen toxicity by alcohol
12. Alcoholism, non-prescription drug and hepatotoxicity
13. Late presentation of acetaminophen hepatotoxicity
14. Severe hepatic damage after acetaminophen use in psittacosis
15. Ulcer, back pain and jaundice in an alcoholic
16. Acetaminophen hepatotoxicity associated with alcoholic pancreatitis
17. Elevated SGOT/ SGPT ratio in alcoholic patients with acetaminophen toxicity
18. Terapeutiskt paracetammolinting orsakade akut jurunsufficicans och liver parerken
19. Nyquil and acute hepatic necrosis
20. Combined hepatic and renal injury in alcoholics during therapeutic of acetaminophen
21. Enhanced toxicity of acetaminophen in alcoholics
22. Alcoholic, acetaminophen and hepatic necrosis
23. Ethanol enhancement of therapeutic doses of acetaminophen by alcohol
24. Centrilobular hepatic fibrosis following acetaminophen-induced hepatic necrosis in an alcoholic
25. Acetaminophen toxicity in alcoholic
26. Severe liver damage after therapeutic doses of paracetamol
27. Les hepatitis par toxicite subaigue du paracetaol existent elles?
28. Paracetamol medication and alcohol abuse: a dangerous combination for the liver and kidney
29. Severe liver damage caused by therapeutic doses of acetaminophen
30. Hepatonephritic aigue chez l'alcoolique apres prise de paracetamol a dop therapeutic
31. Toxicité hepatique et renate de paracetamol chez 1 alcoolique chronique
32. Acute renal failure in alcoholic during therapeutic acetaminophen digestion
33. Long term sequelae of acetaminophen associated fulminant hepatic failure
34. Nyquil-associated liver injury
35. Acetaminophen hepatotoxicity in the alcoholic
36. Failure of physicians to recognize acetaminophen hepatotoxicity in alcoholics
37. Clinical features of acetaminophen toxicity
38. Paracetamol toxicity in chronic alcohol abusers—a plea for greater consumer awareness
39. Hepatotoxicity due to repeated intake of low doses of paracetamol
40. Acetaminophen and the liver
41. Association of acetaminophen hepatotoxicity with fasting and ethanol use
42. Acute liver failure and encephalopathy in a 15 month old infant
43. Fatal hepatotoxicity in a 2 year old
44. Probable acetaminophen toxicity in an 18 month old infant due to repeated over dosing
45. Hepatic failure following ingestion of multiple doses of acetaminophen in a young child
46. The spectrum of paracetamol (acetaminophen) overdosage clinical and epidemiological studies
47. Acetaminophen as an aspirin substitute
48. Steatonecrosis—Mallory body type
49. Computer analysis of liver function tests and their interrelationship in 347 cases of viral hepatitis
50. Serum enzymes in liver disease
51. Clinical significant of alterations in transaminase activities in serum and other body fluids
52. Report of American Association of Poison Control Centers
53. Acetaminophen-induced hepatic necrosis: IV Protective role of glutathione
54. Acetaminophen-induced hepatic necrosis II. Role of covalent binding in vivo
55. Effects of alcohol on other hepatotoxins
56. Hepatic effects of acetaminophen: enhanced toxicity in alcoholics
57. Acetaminophen, alcohol and cytochrome P450
58. Molecular mechanism of the hepatotoxicity caused by acetaminophen
59. Comparison of six rabbit liver cytochrome P-450 isozymes in formation of a reactive metabolite of acetaminophen
60. Role of cytochrome P450 in drug metabolism and hepatotoxicity
61. Biochemical factors in alcoholic liver disease
62. Increased hepatotoxicity of acetaminophen after chronic consumption in the rat
63. Hepatic microsomal enzymes in man and rats: induction and inhibition by ethanol
64. Modulation of cytochrome P450 isozymes in human liver by ethanol and drug intake
65. Interaction of ethanol with acetaminophen metabolism in the baboon
66. Increased metabolism of acetaminophen in chronically ill alcoholic patients
67. Biochemical and molecular basis of alcohol-induced injury to liver and other tissue
68. Ethanol induction of acetaminophen toxicity and metabolism
69. Pharmacokinetics and metabolism of acetaminophen in normal, alcoholic and cirrhotic subjects
70. Paracetamol metabolism in heavy drinkers
71. Drug interactions affect analgesic toxicity
72. Glutathione deficiency in alcoholic: risk factor for paracetamol
73. Increased paracetamol hepatotoxicity after chronic alcoholic consumption
74. Increased acetaminophen-induced hepatotoxicity after chronic consumption in mice
75. Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage
76. The effect of chronic alcohol intake on prognosis and outcome in paracetamol overdose
77. Hepatotoxicity from paracetamol self-poisoning in Western Sydney: a continuing challenge
78. Prevention of acetaminophen-induced hepatotoxicity by acute ethanol administration in the rat
79. Mechanism of the preventive effect of ethanol on acetaminophen-induced hepatotoxicity
80. The effect of mild alcohol consumption on the metabolism of acetaminophen in man
81. Interaction of acute ethanol administration with acetaminophen metabolism and toxicity in rats fed alcohol chronically
82. Acute liver failure