Differential induction of tumor necrosis factor α and manganese superoxide dismutase by endotoxin in human monocytes: Role of protein tyrosine kinase, mitogen-activated protein kinase, and nuclear factor κB

Journal of Cellular Physiology

Volumn 182, Issue 3, 2000, Pages 381-389

  White, Julie E ^a   Lin, Hung Yun ^a,b   Davis, Faith B ^b   Davis, Paul J ^b   Tsan, Min Fu ^a,b  

^a STRATTON VA MEDICAL CENTER   (United States)

^b ALBANY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DITHIOCARBAMIC ACID DERIVATIVE; ENDOTOXIN; GENISTEIN; GLIOTOXIN; HERBIMYCIN A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MANGANESE SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS;

BENZOQUINONES; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENISTEIN; HUMANS; LACTAMS, MACROCYCLIC; LIPOPOLYSACCHARIDES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MONOCYTES; NF-KAPPA B; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; QUINONES; RNA, MESSENGER; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE;

EID: 0033958358     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(200003)182:3<381::AID-JCP9>3.0.CO;2-F     Document Type: Article

References (48)

1. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe SI, Itoh N, Shibuya M, Fukami Y. 1987. Genistein, a specific inhibitor of tyrosine-specific protein kinase. J Biol Chem 262:5592-5595.
2. Asayama K, Janco RL, Burr IM. 1985. Selective induction of manganous superoxide dismutase in human monocytes. Am J Physiol 249:C393-397.
3. Beaty CD, Franklin TL, Uehara Y, Wilson CB. 1994. Lipopolysaccharide-induced cytokine production in human monocytes: role of tyrosine phosphorylation in membrane signal transduction. Eur J Immunol 24:1278-1284.
4. Beauchamp C, Fridovich I. 1971. Superoxide dismutase: improved assay and an assay application to acrylamide gels. Anal Biochem 44:276-282.
5. Beutler B, Krochin N, Milsark IW, Luedke C, Cerami A. 1986a. Control of cachetin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. Science 232: 977-980.
6. Beutler B, Kruys V. 1995. Lipopolysaceharide signal transduction, regulation of tumor necrosis factor biosynthesis, and signaling by tumor necrosis factor itself. J Cardiovasc Pharmacol. 25:S1-S8.
7. Beutler B, Milsark IW, Cerami A. 1985. Passive immunization against cachetin/tumor necrosis factor (TNF) protects mice from the lethal effect of endotoxin. Science 229:869-871.
8. Beutler B, Tkacenko V, Milsark IW, Krochin N, Cerami A. 1986b. Effect of γ interferon on cachetin expression by mononuclear phagocytes. J Exp Med 164:1791-1796.
9. Carter AB, Monick MM, Powers LS, Hunninghake GW. 1998. Endotoxin-stimulated alveolar macrophages require both ERK and p38 kinases for optiomal cytokine gene expression. Am J Respir Crit Care Med 157:A738.
10. Chomczynski P, Sacchi N. 1987. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
11. d) mice respond to bacterial lipopolysaccharide by activating NF-κB. J Leukoc Biol 57:174-179.
12. Faure V, Courtois Y, Goureau O. 1998. Tyrosine kinase inhibitors and antioxidants modulate NF-κB and NOS-II induction in retinal epithelial cells. Am J Physiol 275:C208-215.
13. Fukazawa H, Li PM, Yamamoto C, Murakami Y, Mizuno S, Uehara Y. 1991. Specific inhibition of cytoplasmic protein tyrosine kinases by herbimycin A in vitro. Biochem Pharmacol 42:1661-1671.
14. Geng Y, Zhang B, Lotz M. 1993. Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human monocytes. J Immunol 151:6692-6700.
15. Geppert TD, Whitehurst CE, Thompson P, Beutler B. 1994. LPS signals activation of TNF biosynthesis through the RAS/RAF-1/MEK/MAPK pathway. Mol Med 1:93-103.
16. Han J, Brown T, Beutler B. 1990. Endotoxin-responsive sequences control cachetin/tumor necrosis factor biosynthesis at the translational level. J Exp Med 171:465-475.
17. Han J, Huez G, Beutler B. 1991. Interactive effects of the tumor necrosis factor promoter and 3′-untranslated regions. J Immunol 146:1843-1848.
18. Haziot A, Chen S, Ferrero E, Low MG, Silber R, Goyert SM. 1988. The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phospatidylinositol linkage. J Immunol 141:547-552.
19. Kinningham KK, Devalaraja MN, Yeh CC, Majima H, Kasarskis EJ, St. Clair DK. 1998. Identification of enhancer elements responsible for regulation of the human MnSOD gene by TNF and IL-1. Free Radic Biol Med 25:S54.
20. Lee JC, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D, McNulty D, Blumenthal MJ, Heys JR, Landvatter SW, Stricker JE, McLaughlin MM, Siemens IR, Fisher SM, Livi GP, White JR, Adams JL, Young PR. 1994. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372:739-746.
21. Mathews DE, Farewell VT. 1988. Data analysis. In: Mathews DE and Farewell VT, editors. Using and understanding medical statistics. Basel: Karger, p 167-181.
22. McCord JM, Fridovich I. 1969. Superoxide dismutase. An enzymatic function for erythrocuprein (hemocuprein). J Biol Chem 244:6049-6055.
23. Morrison DC, Ryan JL. 1979. Bacterial endotoxins and host immune responses. Adv Immunol 28:293-450.
24. O'Connell MA, Bennett BL, Mercurio F, Manning AM, Mackman N. 1998. Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cells. J Biol Chem 273:30410-30414.
25. Osnes LTN, Foss KB, Joo GB, Okkenhaug C, Westvik A-B, Ovstebo R, Kierulf P. 1996. Acetylsalicylic acid and sodium salicylate inhibit LPS-induced NF-κB/c-Rel nuclear translocation, and synthesis of tissue factor (TF) and tumor necrosis factor alfa (TNF-α) in human monocytes. Thromb Haemost 76:970-976.
26. Phal HL, Kraub B, Schulze-Osthoff K, Decker T, Traenckner BME, Vogt M, Myers C, Parks T, Warring P, Muhlbacher A, Czernilofsky AP, Baeuerle PA. 1996. The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor-κB. J Exp Med 183:1829-1840.
27. Reiman T, Buscher D, Hipskind RA, Krautwald S, Lohmann-Matthes M-L, Baccarini M. 1994. Lipopolysaccharide induces activation of the Raf-1/MAPK kinase pathway. A putative role for Raf-1 in the induction of the IL-1 beta and TNF-alpha genes. J Immunol 153: 5740-5749.
28. Rietschel ETh, Brade H. 1992. Bacterial endotoxins. Sci Am 267:54-61.
29. Schreck R, Meier B, Mannel DN, Droge W, Baeuerle PA. 1992. Dithiocarbamates as potent inhibitors of nuclear factor κB activation in intact cells. J Exp Med 175:1181-1194.
30. Shakhov AN, Collart MA, Vassalli P, Nedospasov SA, Jongeneel CV. 1990. κB-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor a gene in primary macrophages. J Exp Med 171:35-47.
31. Shiki Y, Meyerick BO, Brigham KL, Burr IM. 1989. Endotoxin increases superoxide dismutase in cultured bovine pulmonary endothelial cells. Am J Physiol 252:C436-440.
32. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC. 1985. Measurement of protein using bicinchoninic acids. Anal Biochem 150:76-85.
33. Somerville Jr JE, Cassiano L, Bainbridge B, Cunningham MD, Darveau RP. 1996. A novel Escherichia coli lipid A mutant that produces an antiinflammatory lipopolysaccharide. J Clin Invest 97:359-365.
34. lyn. J Biol Chem 268:20725-20728.
35. Sweet MJ, Hume DA. 1996. Endotoxin signal transduction in macrophages. J Leukoc Biol 60:8-26.
36. Tang G, Berg JT, White JE, Lumb PD, Lee CY, Tsan MF. 1994. Protection against oxygen toxicity by tracheal insufflation of endotoxin: role of MnSOD and alveolar macrophages. Am J Physiol 266:L38-L45.
37. Tian L, White JE, Lin HY, Haran VS, Sacco J, Chikkappa G, Davis FB, Davis PJ, Tsan MF. 1998. Induction of MnSOD in human monocytes without inflammatory cytokine production by a mutant endotoxin. Am J Physiol 275:C740-747.
38. Toullec D, Pianetti P, Coste H, Bellevergue P, Grand-Perret T, Ajakane M, Baudet V, Boissin P, Boursier E, Loriolle F, Duhamel L, Charon D, Kirilovsky J. 1991. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J biol Chem 26:15771-15781.
39. Tsan MF. 1997. Superoxide dismutase and pulmonary oxygen toxicity. Proc Soc Exp Biol Med 214:107-113.
40. Tsan MF, Lawrence D, White JE. 1991. Erythrocyte insufflation-induced protection against oxygen toxicity: Role of cytokines. J Appl Physiol 71:1751-1757.
41. Tsan MF, Tsan G, White JE. 1997. Surfactant inhibits cationic liposome-mediated gene transfer. Hum Gene Ther 8:817-825.
42. Tsan MF, White JE, Caska B, Epstein CJ, Lee CY. 1998. Susceptibility of heterozygous MnSOD gene-knockout mice to oxygen toxicity. Am J Respir Cell Mol Biol 19:114-120.
43. Wan XS, Devalraja MN, St. Clair DK. 1994. Molecular structure and organization of the human manganese superoxide dismutase gene. DNA Cell Biol 13:1127-1136.
44. Wen Z, Zhong Z, Darnell JE Jr. 1995. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82:241-250.
45. White JE, Tsan MF. Induction of pulmonary Mn superoxide dismutase mRNA by interleukin-1. Am J Physiol 266:L664-671.
46. Wright SD, Ramos RA, Tobias PS, Ulevich RJ, Mathison JC. 1990. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249:1431-1433.
47. Yang RB, Mark A, Gray A, Huang A, Xie MH, Zhag M, Goddard A, Wood WI, Gurney AL, Godowski PJ. 1998. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature 395: 284-288.
48. Young P, McDonnell P, Dunnington D, Hand A, Laydon J, Lee J. 1993. Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level. Agents Actions 39:C67-69.