Reflections on the implications of thresholds of mutagenic activity for the labelling of chemicals by the European Union

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 464, Issue 1, 2000, Pages 155-158

  Parry, James M ^a  

^a SWANSEA UNIVERSITY   (United Kingdom)

Author keywords

Hazard; Management; Risk; Threshold

Indexed keywords

MUTAGENIC AGENT;

ARTICLE; DOSE RESPONSE; DRUG CLASSIFICATION; EUROPEAN UNION; MAXIMUM ALLOWABLE CONCENTRATION; MUTAGENICITY; PRIORITY JOURNAL; RISK ASSESSMENT;

DOSE-RESPONSE RELATIONSHIP, DRUG; EUROPEAN UNION; HUMANS; MUTAGENS; RISK ASSESSMENT; TOXICOLOGY;

EID: 0033958268     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(99)00177-1     Document Type: Article

References (10)

1. Annex VI to Commission Directive 93/21/EEC, Official Journal of European Economic Community L 110A, Vol. 36, 4 May 1993.
2. Müller L., Kasper P. Human biological relevance and the use of threshold-arguments in regulatory genotoxicity assessment: experience with pharmaceuticals. Mutat. Res. 464:2000;19-34. this issue.
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4. Autrup H. Genetic polymorphisms in human xenobiotica metabolizing enzymes as susceptibility factors in toxic response. Mutat. Res. 464:2000;65-76. this issue.
5. Parry J.M., Jenkins G.J.S., Haddad F., Bourner R., Parry E.M. In vitro and in vivo extrapolations of genotoxin exposures: consideration of factors which influence dose-response thresholds. Mutat. Res. 464:2000;53-63. this issue.
6. Bentley K.S., Kirkland D., Murphy M., Marshall R. Evaluation of thresholds for benomyl-and carbendazim-induced aneuploidy in cultured human lymphocytes using fluorescence in situ hybridization. Mutat. Res. 464:2000;41-52. this issue.
7. Kirsch-Volders M., Aardema M., Elhajouji A. Concepts of threshold in mutagenesis and carcinogenesis. Mutat. Res. 464:2000;3-11. this issue.
8. Sofuni T., Hayashi M., Nohmi T., Matsuoka A., Yamada M., Kamata E. Semi-quantitative evaluation of genotoxic activity of chemical substances and evidence for a biological threshold of genotoxic activity. Mutat. Res. 464:2000;97-104. this issue.
9. Moustacchi E. DNA damage and repair: consequences on dose-responses. Mutat. Res. 464:2000;35-40. this issue.
10. Swenberg J.A., Ham A., Koc H., Morinello E., Ranasinghe A., Tretyakova N., Upton P.A., Wu K.Y. DNA adducts: effects of low exposure to ethylene oxide, vinyl chloride and butatiene. Mutat. Res. 464:2000;77-86. this issue.