Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance

British Journal of Cancer

Volumn 82, Issue 2, 2000, Pages 488-491

  Lage, H ^a   Helmbach, H ^b   Dietel, M ^a   Schadendorf, D ^b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Cisplatin; Drug resistance; Etoposide; Fotemustine; Melanoma; Vindesine

Indexed keywords

CISPLATIN; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; FOTEMUSTINE; VINDESINE;

ARTICLE; CONTROLLED STUDY; DRUG RESISTANCE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MELANOMA CELL; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0033957570     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.1999.0947     Document Type: Article

References (18)

1. Boege F, Andersen A, Jensen S, Zeidler R and Kreipe H (1995) Proliferation-associated nuclear antigen Ki-S1 is identical with topoisomerase IIα. Am J Pathol 146: 1302-1308
2. Campain JA, Padmanabhan R, Hwang J, Gottesman MM and Pastan I (1993) Characterization of an unusual mutant of human melanoma cells resistant to anticancer drugs that inhibit topoisomerase II. J Cell Physiol 155: 414-425
3. Campain JA, Gottesman MM and Pastan I (1994) A novel mutant topoisomerase II alpha present in VP-16-resistant human melanoma cell lines has a deletion of alanine 429. Biochemistry 37: 11327-11332
4. Danks MK, Schmidt CA, Cirtain MC, Suttle DP and Beck WT (1988) Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26. Biochemistry 27: 8861-8869
5. Danks MK, Warmoth MR, Friche E, Granzen B, Bugg BY, Harker WG, Zwelling LG, Futscher BW, Suttle DP and Beck WT (1993) Single-strand conformational polymorphism analysis of the M(r) 170,000 isoenzyme of DNA topoisomerase II in human tumor cells. Cancer Res 53: 1373-1379
6. Fogh J, Bean MA, Brüggen J, Fogh H, Fogh JM, Hammar SP, Kodera Y, Loveless JD, Sorg C and Wright WC (1978) Comparison of a human tumor cell line before and after growth in the nude mouse. In: The Nude Mouse in Experimental and Clinical Research, Fogh J and Giovanella B (eds), pp. 215-234. Academic Press: New York
7. Jenkins JR, Ayton P, Jones T, Davies SL, Simmons DL, Harris AL, Sheer D and Hickson ID (1992) Isolation of cDNA clones encoding the β isozyme of human DNA topoisomerase II and localization of the gene to chromosome 3p24. Nucleic Acids Res 20: 5587-5592
8. Kellner U, Hutchinson L, Seidel A, Lage H, Danks MK, Dietel M and Kaufmann SC (1997) Decreased drug accumulation in a mitoxantrone-resistant gastric carcinoma cell line in the absence of P-glycoprotein. Int J Cancer 71: 817-824
9. Kern MA, Helmbach H, Artuc M, Karmann D, Jurgovsky K and Schadendorf D (1997) Human melanoma cell lines selected in vitro displaying various levels of drug resistance against cisplatin, fotemustine, vindesine or etoposide: modulation of proto-oncogene expression. Anticancer Res 17: 4359-4370
10. k-methylguanine-DNA methyltransferase and N-methylpurine-DNA glycosylase in melanoma cells with acquired drug resistance. Int J Cancer 80: 744-750
11. Liu LF (1989) DNA topoisomerase poisons as antitumor drugs. Annu Rev Biochem 58: 351-375
12. Liu LF, Rowe TC, Yang L, Tewey KM and Chen GL (1983) Cleavage of DNA by mammalian DNA topoisomerase II. J Biol Chem 258: 15365-15370
13. Marini JC, Miller KG and Englund PT (1980) Decatenation of kinetoplast DNA by topoisomerase II. J Biol Chem 255: 4976-4979
14. Nelson EM, Tewey KM and Liu LF (1984) Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4′-(9-acridinylamino)-methanesulfon-m-aniside. Proc Natl Acad Sci USA 81: 1361-1365
15. Osheroff N, Corbett AH and Robinson M (1994) Mechanism of action of topoisomerase II-targeted antineoplastic drugs. Adv Pharmacol 29, 105-126
16. Son YS, Suh JM, Ahn SH, Kim JC, Yi JY, Hur KC, Hong W-S, Muller MT and Chung IK (1998) Reduced activity of topoisomerase II in an adriamycin-resistant human stomach-adenocarcinoma cell line. Cancer Chemother Pharmacol 41: 353-360
17. Takano H, Kohno K, Ono M, Uchida Y and Kuwano M (1991) Increased phosphorylation of DNA topoisomerase II in etoposide-resistant mutants of human cancer KB cells. Cancer Re 51: 3951-3957
18. Walker PR, Smith C, Youdale T, Leblanc J, Whitfield JF and Sikorska M (1991) Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes. Cancer Res 51: 1078-1085