Decreased drug accumulation in a mitoxantrone-resistant gastric carcinoma cell line in the absence of P-glycoprotein

International Journal of Cancer

Volumn 71, Issue 5, 1997, Pages 817-824

  Kellner, Udo ^a,f   Hutchinson, Lesley ^b   Seidel, André ^a   Lage, Hermann ^c   Danks, Mary K ^d   Dietel, Manfred ^c   Kaufmann, Scott H ^e  

^a UNIVERSITY OF KIEL   (Germany)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^e MAYO CLINIC   (United States)

^f UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; AMETANTRONE; AMSACRINE; CAMPTOTHECIN; DAUNORUBICIN; DOXORUBICIN; ETOPOSIDE; GLYCOPROTEIN P; MITOXANTRONE; TENIPOSIDE; TOPOTECAN;

ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG RESISTANCE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; STOMACH CARCINOMA;

EID: 0030922194     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970529)71:5<817::AID-IJC20>3.0.CO;2-3     Document Type: Article

References (24)

1. CHANG, J.Y., DETHLEFSEN, L.A., BARLEY, L.R., ZHOU, B.S. and CHHNG, Y.C., Characterization of camptothecin-resistant Chinese hamster luns cells. Biochem. Pharmacol., 42, 2443-2452 (1992).
2. COLE, S.P., SPARKS, K.E., FRASER, K., LOE, D.W., GRAND, C.E., WILSON, G.M. and DEELEY, R.G., Pharmacological characterization of multidrug-resistant MRP-transfected human tumor cells. Cancer Res., 54, 5902-5910 (1994).
3. CRRSPI, M.O., IVANIER, S.E., GENOVESE, J. and BALDI, A., Mitoxantrone affects topoisomerase activities in human breast cancer cells. Biochem. biophys. Res. Comm., 136, 521-528 (1986).
4. DANKS, M.K., WARMOTH, E.F., FRICHE, E., GRANZEN, B., BUGG, B.Y., HARKER, W.G., ZWELLING, L.A., FUTSCHER, B.W., SUTTLE, D.P. and BECK, W.T., Single-strand conformational polymorphism analysis of the Mr 170,000 isoenzyme of DNA topo II in human tumor cells. Cancer Res., 53, 1373-1379 (1993).
5. DIETEL, M., ARPS, H., LAGE, H. and NIENDORF, A., Membrane vesicle formation due to acquired mitoxantrone resistance in human gastric carcinoma cell line EPG 85-257. Cancer Res., 50, 6100-6106 (1990)
6. DURR, F.E., Biolosic and biochemical effects of mitoxantrone. Seinin. Oncol., 11, (Suppl 1), 3-19 (1984).
7. FOYE, W.O., VAJRAGUPTA, O. and SENGUPTA, S.K., DNA-binding specificity and RNA polymerase inhibitory activity of bis(aminoalkyl)anthraquinones and bis(methylthio)vinylquinolium iodides. J. pharm. Sci., 71, 235-256 (1982).
8. FUTSCHER, B.W., ABBASZADEGAN, M.R., DOMANN, F. and DALTON, W.S., Analysis of MRP mRNA in mitoxantrone-selected. multidrug-resistant human tumor cells. Biochem. Pharmacol., 47, 1601-1606 (1994).
9. HARKER, W.G., SLADE, D.L., DALTON, W.S., METZLER, P.S. and TRENT, J.M., Multidrug resistance in mitoxantrone-selected HL-60 leukemia cells in the absence of P-170 overexpression. Cancer Res., 49, 4542-4549 (1989).
10. HSIANG, Y.-H. and LIU, L.F., Identification of mammalian DNA topo I as an intracellular tarset of the anticancer drug camptothecin. Cancer Res., 48, 1722-1726 (1988).
11. KAPUSCINSKI, J. and DARZYNKIEWICZ, Z., Relationship between the pharmacological activity of antitumor drugs ametantrone and mitoxantrone (novantrone) and their ability to condense nucleic acids. Proc. nat. Acad. Sci. (Wash.), 83, 6302-6306 (1986).
12. KASHANI-SABET, M. and 12 OTHERS. Reversal of the malignant phenotype by an anti-ras ribozyme. Antisense Res. Dev., 2, 3-15 (1992).
13. KAUFMANN, S.H., MCLALGHLIN, S.J., KASTAN, M.B., LIU, L.F., KARP, J.E. and BURKE, P.J., Topoisomerase II levels during granulocytic maturation in vitro and in vivo. Cancer Res., 51, 3534-3543 (1991).
14. LEFEVRE, D., RIOR, J.F., AHOMADEGBE, J.C., ZHOU, D.Y., BERNARD, J. and RIOU, G., Study of molecular markers of resistance to m-AMSA in a human breast cancer cell line. Decrease of topoisomerase II and increase of both topoisomerase I and acidic glutathione-S transferase. Biochem. Pharmacol., 41, 1967-1979 (1991).
15. LOWN, J.W. and HANSTOCK, C.C., High-field H-NMR analysis of the 1:1 intercalation complex of the antitumor agent mitoxantrone and the DNA duplex [d(CP-170CpG)|2. J. biomol. Struct. Dyn., 2, 1097-1106 (1985).
16. NAKAGAWA, M., SCHNEIDER, E., DIXON, K.H., HORTON, J., KELLEY, K., MORROW, C. and COWAN, K.H., Reduced intracellular drug accumulation in the absence of P-170 (mdrl) overexpression in mitoxantrone-resistant human MCF-7 breast cancer cells. Cancer Res., 52, 6175-6181 (1992).
17. POMMIER, Y., SCHWARTZ, R.E., KOHN, K.W. and ZWELLING, L.A., Formation and rejoining of deoxyribonucleic acid double-strand breaks induced in isolated cell nuclei by antineoplastic intercalating agents. Biochemistry, 23, 3194-3201 (1984).
18. SCHEPER, R.J., BULTE, J.W., BRAKKEE, J.G., QUAK, J.J., VAN DER SCHOOT, E., BALM, A.J., MEUER, C.L., BROXTERMAN, H.J., KUIPER, C.M., LANKELMA, J. and PINEDO, H.M., Monoclonal antibody JSB-I detects a highly conserved epitope on the P-slycoprotein associated with muhidrug resistance. Int. J. Cancer, 42, 389-394 (1988).
19. SCHNEIDER, E., HORTON, J.K., YANG, C.-H., NAKAGAWA, M. and COWAN, K.H., Multidrug resistance-associated protein overexpression and reduced drug sensitivity of topo II in a human breast carcinoma MCF7 cell line selected for etoposide resistance. Cancer Res., 54, 152-158 (1994).
20. SEIDEL, A., HASMANN, M., LÖSER, R., BUNGE, A., SCHAEFER, B., HERZIG, I., STEINMANN, K. and DIETEL, M., Intracellular location, vesicular accumulation and kinetics of daunorubicin in sensitive and multidrug-resistant gastric carcinoma EPG85-257 cells. Virchows Arch., 426, 249-256 (1995).
21. SMITH, P.J., SYKES, H.R., FOX, M.E. and FURLONG. I.J., Subcellular distribution of the anticancer drug mitoxantrone in human and drug-resistant muine cells analyzed by flow cytometry and contbcal microscopy and its relationship to the induction of DNA damage. Cancer Res., 52, 4000-4008 (1992).
22. SULLIVAN, D.M., FELDHOFF, P.W., LOCK. R.B., SMITH, N.B. and PIERCE, W.M., Characterisation of an altered DNA topoisomerase IIα from a mitoxantrone-resistant mammalian cell line hypersensitive to DNA crosslinking agents. Int. J. Oncol., 7, 1383-1393 (1995).
23. WALLACE, R.E., LINDH, D. and DURR, F.E., Development of resistance and characteristics of a human colon carcinoma subline resistant to mitoxantrone in vivo. Cancer Invest., 5, 417-128 (1987).
24. YANG, C.J., HORTON, J.K., COWAN, K.H. and SCHNEIDER, E., Cross-resistance to camptothecin analogues in a mitoxantrone-resistant human breast carcinoma cell line is not due to DNA topoisomerase I alterations. Cancer Res., 55, 4004-4009 (1995).