Cell proliferation and Ca2+-calmodulin dependent protein kinase activation mediated by α(1A)- and α(1B)-adrenergic receptor in HEK293 cells

Acta Pharmacologica Sinica

Volumn 21, Issue 1, 2000, Pages 55-59

  Gao, Ben Bo ^a   Lei, Bei Lei ^a   Zhang, You Yi ^a   Han, Qi De ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Alpha 1 adrenergic receptors; Ca2+ calmodulin dependent protein kinase; Cell division; HEK293 cells; Norepinephrine; Plasmids; Propranolol; Radioligand assay; Recombinant DNA; Thymidine

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; CALCIUM PHOSPHATE; DNA; MYELIN BASIC PROTEIN; NORADRENALIN; PRAZOSIN; PROPRANOLOL; PROTEIN KINASE (CALCIUM,CALMODULIN); RECEPTOR SUBTYPE; RECOMBINANT DNA; THYMIDINE;

ARTICLE; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; KIDNEY CELL; PLASMID; PROTEIN EXPRESSION; RADIOASSAY;

ADRENERGIC ALPHA-AGONISTS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DIVISION; CELLS, CULTURED; EMBRYO; HUMANS; KIDNEY; NOREPINEPHRINE; RECEPTORS, ADRENERGIC, ALPHA-1; TRANSFECTION;

EID: 0033957548     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Blaes N, Boissel JP. Growth-stimulating effect of catecholamines on rat aortic smooth muscle cells in culture. J Cell Physiol 1983; 116: 167-72.
2. 2-adrenergic inhibition of DNA synthesis in vascular smooth muscle cells. Mol Pharmacol 1990; 37: 30-6.
3. Yu SM, Tsai SY, Guh JH, Ko FN, Teng CM, Ou JT. Mechanism of catecholamine-induced proliferation of vascular smooth muscle cells. Circulation 1996; 94: 547-54.
4. 1-adrenergic receptor subtypes activation on proliferation of smooth muscle cells in rabbit aorta. Acta Physiol Sin 1995; 47: 498-504.
5. 1-adrenergic receptor subtypes in cultured rabbit aortic vascular smooth muscle cells. J Cardiovasc Pharmacol 1996; 27: 508-18.
6. 1-adrenoreceptor subtypes in vitro and in situ. J Biol Chem 1995; 270: 30980-8.
7. 1D-adrenergic receptors and mitogen-activated protein kinase mediate increased protein synthesis by arterial smooth muscle. Mol Pharmacol 1997; 51: 764-75.
8. 1-adrenoceptors. Eur J Pharmacol 1981; 73: 221-4.
9. 1-adrenergic receptor subtypes. Mol Pharmacol 1994; 46; 929-36.
10. Cornwell TL, Arnold E, Boerth NJ, Lincoln TM. Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP. Am J Physiol 1994; 36 (5 Pt 1): C1405-13.
11. Hu ZW, Shi XY, Lin RZ, Hoffman BB. (1 adrenergic receptors activate phosphatidylinositol 3-kinase in human vascular smooth muscle cells. Role in mitogenesis. J Biol Chem 1996; 271: 8977-82.
12. q-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase. J Biol Chem 1997; 272: 19125-32.