Genetic mapping of the rat mutation creeping and evaluation of its positional candidate gene reelin

Mammalian Genome

Volumn 11, Issue 2, 2000, Pages 111-114

  Yokoi, Norihide ^a,b   Shimizu, Seiko ^c   Ishibashi, Kotaro ^d   Kitada, Kazuhiro ^b   Iwama, Hiroyuki ^c   Namae, Misako ^e   Sugawara, Moriyuki ^c   Serikawa, Tadao ^b   Komeda, Kajuro ^e  

^a CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c NIPPON VETERINARY AND LIFE SCIENCE UNIVERSITY   (Japan)

^d DAIICHI SANKYO CO   (Japan)

^e TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

REELIN;

ANIMAL CELL; ARTICLE; AUTOSOMAL RECESSIVE INHERITANCE; CELL SURVIVAL; COLONY FORMATION; GENE DISRUPTION; GENE MAPPING; GENE MUTATION; GENETIC LINKAGE; HAPLOTYPE; NEUROPATHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN EXPRESSION; PURKINJE CELL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BLOTTING, NORTHERN; CELL ADHESION MOLECULES, NEURONAL; CEREBELLUM; CHROMOSOME MAPPING; EXTRACELLULAR MATRIX PROTEINS; HAPLOTYPES; MICE; MICE, NEUROLOGIC MUTANTS; NERVE TISSUE PROTEINS; RATS; RATS, ZUCKER; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERINE ENDOPEPTIDASES;

EID: 0033957182     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003350010022     Document Type: Article

References (22)

1. Bar I, Lambert De Rouvroit C, Royaux I, Krizman DB, Dernoncourt C et al. (1995) A YAC contig containing the reeler locus with preliminary characterization of candidate gene fragments. Genomics 26, 543-549
2. D'Arcangelo G, Miao GG, Chen SC, Soares HD, Morgan JI et al. (1995) A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature 374, 719-723
3. Falconer DS (1951) Two new mutations, trembler and reeler, with neurological actions in the house mouse. J Genet 50, 192-201
4. Hamburgh M (1963) Analysis of the postnatal developmental effects of "reeler," a neurological mutation in mice. A study in developmental genetics. Dev Biol 8, 165-185
5. Hirotsune S, Takahara T, Sasaki N, Hirose K, Yoshiki A et al. (1995) The reeler gene encodes a protein with an EGF-like motif expressed by pioneer neurons. Nat Genet 10, 77-83
6. Ishibashi K, Komeda K, Sekiguchi F, Kanazawa Y (1989) Creeping. A new mutant rat with neurological disease. Lab Anim Sci 39, 132-136
7. Manly KF (1993) A Macintosh program for storage and analysis of experimental genetic mapping data. Mamm Genome 4, 303-313
8. Matsuda Y, Takahara T, Kusakabe M, Hayashizaki Y (1996) Comparative mapping of the reeler gene on human chromosome 7q22, rat chromosome 4q11.2, and mouse chromosome 5 A3-B1. Mamm Genome 7, 468-469
9. Mikoshiba K, Nagaike K, Kohsaka S, Takamatsu K, Aoki E et al. (1980) Developmental studies on the cerebellum from reeler mutant mouse in vivo and in vitro. Dev Biol 79, 64-80
10. Mouse Genome Database (1998) Mouse Genome Informatics Project, The Jackson Laboratory, Bar Harbor, Maine. World Wide Web (URL: http:// www.informatics.jax.org/mgd.html.)
11. Ohshima T, Nagle JW, Pant HC, Joshi JB, Kozak CA et al. (1995) Molecular cloning and chromosomal mapping of the mouse cyclin-dependent kinase 5 gene. Genomics 28, 585-588
12. Ohshima T, Ward JM, Huh C-G, Longenecker G, Veeranna et al. (1996) Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc Natl Acad Sci USA 93, 11173-11178
13. Rat Genome Database (1998) Department of Genetics, Lundberg Laboratory, Göteborg University, Göteborg, Sweden. World Wide Web (URL: http://ratmap.gen.gu.se/)
14. Rice DS, Sheldon M, D'Arcangelo G, Nakajima K, Goldowitz D et al. (1998) Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain. Development 125, 3719-3729
15. rl-Alb2, an allele of reeler isolated from a chlorambucil screen, is due to an IAP insertion with exon skipping. Genomics 42, 479-482
16. Sheldon M, Rice DS, D'Arcangelo G, Yoneshima H, Nakajima K et al. (1997) Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice. Nature 389, 730-733
17. Sweet HO, Bronson RT, Johnson KR, Cook SA, Davisson MT (1996) Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration. Mamm Genome 7, 798-802
18. Takahara T, Ohsumi T, Kuromitsu J, Shibata K, Sasaki N et al. (1996) Dysfunction of the Orleans reeler gene arising from exon skipping due to transposition of a full-length copy of an active L1 sequence into the skipped exon. Hum Mol Genet 5, 989-993
19. Togo M, Numazawa A, Shumiya S, Osanai M (1986) Prolongation of the life of a central nervous system-deficient mouse, the reeler. Exp Anim 35, 109-115
20. Ware ML, Fox JW, Gonzalez JL, Davis NM, Lambert de Rouvroit C et al. (1997) Aberrant splicing of a mouse disabled homolog, mdabl, in the scrambler mouse. Neuron 19, 239-249
21. Yokoi N, Kanazawa M, Kitada K, Tanaka A, Kanazawa Y et al. (1997) A non-MHC locus essential for autoimmune type I diabetes in the Komeda diabetes-prone rat. J Clin Invest 100, 2015-2021
22. Yoneshima H, Nagata E, Matsumoto M, Yamada M, Nakajima K et al. (1997) A novel neurological mutant mouse, yotari, which exhibits reeler-like phenotype but expresses CR-50 antigen/reelin. Neurosci Res 29, 217-223