Dual CCK-A and CCK-B receptor antagonists (II). Preparation and structure activity relationships of 5-alkyl-9-methyl-1,4-benzodiazepines and discovery of FR208419

Chemical and Pharmaceutical Bulletin

Volumn 48, Issue 1, 2000, Pages 1-15

  Tabuchi, Seiichiro ^a   Ito, Harunobu ^a   Sogabe, Hajime ^a   Kuno, Masako ^a   Kinoshita, Takayoshi ^a   Katumi, Ikuyo ^b   Yamamoto, Naoko ^b   Mitsui, Hitoshi ^b   Satoh, Yoshinari ^a  

^a ASTELLAS PHARMA INC   (Japan)

^b NIPPON SHOKUBAI CO LTD   (Japan)

Author keywords

(3R) 1 cyclohexylcarbonylmethyl 5 ethyl 9 methyl 2 oxo 3 (m tolyl)ureido 1,4 benzodiazepine; 5 alkyl 9 methyl 1,4 benzodiazepine; Dual CCK A and B antagonist; Pancreatitis

Indexed keywords

1 (1 CYCLOHEXYLCARBONYLMETHYL 5 ETHYL 2,3 DIHYDRO 9 METHYL 2 OXO 1H 1,4 BENZODIAZEPIN 3 YL) 3 (3 METHYLPHENYL)UREA; 1 CYCLOHEXYLCARBONYLMETHYL 5 ETHYL 9 METHYL 3 (3 TOLYLUREIDO) 2 OXO 1,4 BENZODIAZEPINE; BENZODIAZEPINE DERIVATIVE; CHOLECYSTOKININ A RECEPTOR ANTAGONIST; CHOLECYSTOKININ B RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENANTIOMER; GUINEA PIG; MOUSE; NONHUMAN; OPTICAL RESOLUTION; PANCREATITIS; RAT; RECEPTOR AFFINITY; STOMACH EMPTYING; STRUCTURE ACTIVITY RELATION;

EID: 0033956394     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.48.1     Document Type: Article

References (10)

1. Tabuchi S., Ito H., Sogabe H., Kuno M., Katsumi I., Yamamoto N., Mitsui H., Satoh Y., Bioorg. Med. Chem. Lett., 7, 169-174 (1997).
2. Tabuchi S., Nakanishi I., Satoh Y., Bioorg. Med. Chem. Lett., 8, 1449-1454 (1998).
3. Kuno M., Sogabe H., Ito H., Matuo T., Satoh Y., Motoyama Y., Tanaka H., Pancreas, 17, 57-64 (1998).
4. Satoh Y., Tabuchi S., Mitsui H., Drugs of the Future, 22, 1117-1131 (1997).
5. Sherrill R. G., Sugg E. E., J. Org. Chem., 60, 730-734 (1995).
6. Sugasawa T., Toyoda T., Adachi M., Sasakura K., J. Am. Chem. Soc., 100, 4842-4852 (1978).
7. Houpis I. N., Molina A., Douglas A. W., Xavier L., Lynch J., Volante P. P., Reider P. J., Tetrahedron Lett., 35, 6811-6814 (1994).
8. Ito H., Sogabe H., Nakarai T., Satoh Y., Tomoi Y., Kadowaki M., Matsuo M., Tokoro K. Yoshida K., J. Pharmacol. Exp. Ther., 268, 571-575 (1994).
9. Lotti V. J., Cerino D. J., Kling P. J., Chang R. S. L., Life Sci., 39, 1631-1638 (1986).
10. Kittle K. E., Evans B. E., Bock M. G., DiPardo R. M., Whitter W. L., Homnick C. M., Veter D. F., Freidinger R. M., Tetrahedron Lett., 28, 521-522 (1987).