DNA adducts in liver and leukocytes of flounder (Platichthys flesus) experimentally exposed to benzo[a]pyrene

Aquatic Toxicology

Volumn 48, Issue 2-3, 2000, Pages 177-184

  Malmstrom C M ^a   Miettinen, S ^a   Bylund, G ^a  

^a ÅBO AKADEMI UNIVERSITY   (Finland)

Author keywords

Benzo a pyrene; Biomarker; DNA adduct; Leukocyte; Liver; Platichthys flesus

Indexed keywords

BENZO[A]PYRENE; BIOLOGICAL MARKER; PHOSPHORUS 32;

ARTICLE; CHEMICAL CARCINOGENESIS; DNA ADDUCT; ENVIRONMENTAL MONITORING; FISH; FLOUNDER; ISOTOPE LABELING; LEUKOCYTE; LIVER; NONHUMAN; PRIORITY JOURNAL; WATER CONTAMINATION;

ANIMALIA; PLATICHTHYS FLESUS; PLEURONECTIFORMES; PLEURONECTOIDEI;

EID: 0033952499     PISSN: 0166445X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-445X(99)00033-8     Document Type: Article

References (22)

1. Baan R.A., Steenwinkel M.-J.S.T., van den Berg P.T.M., Roggeband R., van Delft J.H.M. Molecular dosimetry of DNA damage induced by polycyclic aromatic hydrocarbons; relevance for exposure monitoring and risk assessment. Hum. Exp. Toxicol. 13:1994;880-887.
2. 32P-postlabeling assay. Carcinogenesis. 13(7):1992;1053-1074.
3. Dickey C., Santella R.M., Hattis D., Tang D., Hsu Y., Cooper T., Young T.-L., Perera F.P. Variability in PAH-DNA adduct measurements in peripheral mononuclear cells: implications for quantitative cancer risk assessment. Risk Anal. 17(5):1997;649-656.
4. French B.L., Reichert W.L., Hom T., Nishimoto M., Sanborn H.R., Stein J.E. Accumulation and dose-response of hepatic DNA adducts in English sole (Pleuronectes vetulus) exposed to a gradient of contaminated sediments. Aquat. Toxicol. 36:1996;1-16.
5. 32P-postlabeling analysis of nonradioactive aromatic carcinogen-DNA adducts. Carcinogenesis. 3:1982;1081-1092.
6. Hemminki K. DNA adducts, mutations and cancer. Carcinogenesis. 14(10):1993;2007-2012.
7. Maccubbin A.E. DNA adduct analysis in fish: laboratory and field studies. Malins D.C., Ostrander G.K. Aquatic Toxicology: Molecular, Biochemical and Cellular Perspectives. 1994;267-294 Lewis, Boca Raton, FL.
8. Malmström, C., Koponen, K., Lindström-Seppä, P., Bylund, G. Induction and localisation of Cytochrome P4501A in livers of flounder (Platichthys flesus) and Rainbow Trout (Oncorhyncus mykiss) experimentally exposed to Benzo(a)pyrene: an interspecies comparison, submitted to Marine Environ. Res.).
9. McElroy A.E., Cahill J.M., Sisson J.D., Kleinow K.M. Relative bioavailability and DNA adduct formation of benzo[a]pyrene and metabolites in the diet of the Winter flounder. Comp. Biochem. Physiol. 100C:1991;29-32.
10. Nesnow S., Ross J., Nelson G., Holden K., Erexson G., Kligerman A., Gupta R.C. Quantitative and temporal relationships between DNA adduct formation in target and in surrogate tissues: implications for biomonitoring. Environ. Health Perspect. Suppl. 101(3):1993;37-42.
11. Nishimoto M., Yanagida G.K., Stein J.E., Baird W.M., Varanasi U. The metabolism of benzo[a]pyrene by English sole (Parophrys vetulus): comparison between isolated hepatocytes in vitro and liver in vivo. Xenobiotica. 22(8):1992;949-961.
12. Peters L.D., Morse H.R., Waters R., Livingstone D.R. Responses of hepatic cytochrome P450 1A and formation of DNA-adducts in juveniles of turbot (Scophthalmus maximus L.) exposed to water-borne benzo[a]pyrene. Aquat. Toxicol. 38:1997;67-82.
13. 32P-postlabeling test for structurally diverse DNA adducts. Carcinogenesis. 7(9):1986;1543-1551.
14. 32P-postlabeling protocols for assaying levels of hydrophobic DNA adducts in fish. U.S. Dept. Comm., NOAA Tech. Memo. NMFS-NWFSC-14, 89 pp.
15. 32P-postlabeling assay. Carcinogenesis. 13(8):1992;1475-1479.
16. Shaw G.R., Connell D.W. Prediction and monitoring of the carcinogenicity of polycyclic aromatic compounds (PACs). Rev. Environ. Contam. Toxicol. 135:1994;1-62.
17. Sikka H.C., Rutkowski J.P., Kandaswami C., Kumar S., Earley K., Gupta R.C. Formation and persistence of DNA adducts in the liver of brown bullheads exposed to benzo[a]pyrene. Cancer Lett. 49:1990;81-87.
18. 32P-postlabeling analysis of DNA adduct formation and persistence in English sole (Pleuronectes vetulus) exposed to benzo[a]pyrene and 7H-dibenzo[c, g]carbazole. Chem.-Biol. Interact. 88:1993;55-69.
19. Stein J.E., Reichert W.R., Varanasi U. Molecular epizootiology: Assessment of exposure to genotoxic compounds in teleosts. Environ. Health Perspect. 102(12):1994;19-23.
20. van Shooten F.J., Maas L.M., Moonen E.J.C., Kleinjans J.C.S., van der Oost R. DNA dosimetry in biological indicator species living on PAH-contaminated soils and sediments. Ecotoxicol. Environ. Safety. 30:1995;171-179.
21. Varanasi U., Reichert W.L., Le Eberhart B.-T., Stein J.E. Formation and persistence of benzo[a]pyrene-diolepoxide-DNA adducts in liver of English sole (Parophrys vetulus). Chem.-Biol. Interact. 69:1989;203-216.
22. Willett K., Steinberg M., Thomsen J., Narasimhan T.R., Safe S., McDonald S., Beatty K., Kennicutt M.C. Exposure of killifish to benzo[a]pyrene: comparative metabolism, DNA adduct formation and aryl hydrocarbon (Ah) receptor agonist activities. Comp. Biochem. Physiol. 112B(1):1995;93-103.