Novel polymorphism in the coding region of the IL-13 receptor alpha' gene: Association study with atopic asthma in the Japanese population

Experimental and Clinical Immunogenetics

Volumn 17, Issue 1, 2000, Pages 18-22

  Ahmed, Saifuddin ^a   Ihara, Kenji ^a   Sasaki, Yuka ^a   Nakao, Futoshi ^a   Nishima, Sankei ^b   Fujino, Tokihiko ^c   Hara, Toshiro ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b FUKUOKA NATIONAL HOSPITAL   (Japan)

^c Shin Kokura Hospital   (Japan)

Author keywords

Atopic asthma; Interleukin 13; Interleukin 13 receptor '; Polymorphism

Indexed keywords

CYTOSINE; INTERLEUKIN 13 RECEPTOR; INTERLEUKIN 4; NUCLEOTIDE; THYMINE;

ADOLESCENT; ALLELE; ALLERGIC ASTHMA; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; HUMAN; HUMAN TISSUE; JAPAN; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PRIORITY JOURNAL; RACE; SCHOOL CHILD; SCREENING; START CODON;

EID: 0033951423     PISSN: 02549670     EISSN: None     Source Type: Journal    
DOI: 10.1159/000019120     Document Type: Article

References (14)

1. Zurawski G, Vries JE: Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol Today 1994;15:19-26.
2. Sornasse T, Larenas PV, Davis KA, de Vries JE, Yssel H: Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level. J Exp Med 1996;184:473-483.
3. Van der Pouw Kraan TC, Van der Zee JS, Boeije LC, Groot ER, Stapel SO, Aarden LA: The role of IL-13 in IgE synthesis by allergic asthma patients. Clin Exp Immunol 1998;111: 129-135.
4. Punnonen J, Aversa G, Cocks BG, McKenzie AN, Menon S, Zurawski G, de Waal Malefyt R, de Vries JE: Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 1993;90:3730-3734.
5. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, Donaldson DD: Interleukin-13: Central mediator of allergic asthma. Science 1998;282:2258-2261.
6. Aman MJ, Tayebi N, Obiri NI, Puri RK, Modi WS, Leonard WJ: cDNA cloning and characterization of the human interleukin 13 receptor alpha chain. J Biol Chem 1996;271: 29265-29270.
7. Caput D, Laurent P, Kaghad M, Lelias JM, Lefort S, Vita N, Ferrara P: Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain. J Biol Chem 1996;271:16921-16926.
8. Murata T, Taguchi J, Puri RK, Mohri H: Sharing of receptor subunits and signal transduction pathway between the IL-4 and IL-13 receptor system. Int J Hematol 1999; 69:13-20.
9. Rosenwasser LJ, Klemm DJ, Dresback JK, Inamura H, Mascali JJ, Klinnert M, Borish L: Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy. Clin Exp Allergy 1995;25(suppl 2): 74-78.
10. Rosenwasser LJ, Borish L: Genetics of atopy and asthma: The rationale behind promoter-based candidate gene studies (IL-4 and IL-10). Am J Respir Crit Care Med 1997;156: S152-S155.
11. Hershey GK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA: The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N Engl J Med 1997;337:1720-1725.
12. Mitsuyasu H, Yanagihara Y, Mao XQ, Gao PS, Arinobu Y, Ihara K, Takabayashi A, Hara T, Enomoto T, Sasaki S, Kawai M, Hamasaki N, Shirakawa T, Hopkin JM, Izuhara K: Dominant effect of Ile50Val variant of the human IL-4 receptor alpha-chain in IgE synthesis. J Immunol 1999;162:1227-1231.
13. Murata T, Taguchi J, Puri RK: Interleukin-13 receptor alpha' but not alpha chain: A functional component of interleukin-4 receptors. Blood 1998;91:3884-3891.
14. International consensus report on diagnosis and treatment of asthma. National Heart, Lung, and Blood Institute, National Institutes of Health. Bethesda, Maryland 20892. Publication No 92-3091, March 1992. Eur Respir J 1992;5:601-641.