WR-151327 increases resistance to Klebsiella pneumoniae infection in mixed-field- and γ-photon-irradiated mice

International Journal of Radiation Biology

Volumn 76, Issue 2, 2000, Pages 261-271

  Ledney, G D ^a   Elliott, T B ^a   Harding, R A ^a   Jackson III, W E ^a   Inal, C E ^a   Landauer, M R ^a  

^a ARMED FORCES RADIOBIOLOGY RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COBALT 60; PHOSPHOROTHIOIC ACID S 3 (3 METHYLAMINOPROPYLAMINO)PROPYL ESTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; BLOOD CELL; BONE MARROW CELL; COLONY FORMING UNIT GM; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; FEMUR; GAMMA IRRADIATION; HEMATOPOIESIS; INFECTION RESISTANCE; KLEBSIELLA PNEUMONIAE; LEUKOCYTE; LEUKOCYTE COUNT; MOUSE; NEUTRON; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; SURVIVAL; THROMBOCYTE COUNT;

ANIMALIA; BACTERIA (MICROORGANISMS); KLEBSIELLA PNEUMONIAE; NEGIBACTERIA;

EID: 0033950324     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530000138916     Document Type: Article

References (56)

1. Ainsworth, E. J. and Larsen, R. M., 1969, Colony-forming units and survival of irradiated mice treated with AET or endotoxin. Radiation Research, 40, 149-176.
2. American Association of Physicists in Medicine, Task Group 21, Radiation Therapy Committee, 1983, A protocol for the determination of absorbed dose from high-energy photon and electron beams. Medical Physics, 10, 741-771.
3. Aviles, A., Diaz-Maqueo, J. C., Talavera, A., Garcia, E. L., Guzman, R. and Nambo, M. J., 1997, Bone marrow protection with amifostine in the treatment of high-risk malignant lymphoma. European Journal of Cancer, 33, 1323-1325.
4. Broerse, J. J., 1975, RBE values of fast neutrons for damage to organized tissues in experimental animals. In Radiation Research; Biomedical, Chemical and Physical Perspectives, edited by O. F. Nygaard, H. I. Adler and W. K. Sinclair, Proceedings of the 5th International Congress on Radiation Research, Seattle, WA, July 14-20, 1974 (New York: Academic Press), pp. 1073-1082.
5. Brook, I. and Ledney, G. D., 1994, Quinolone therapy in the prevention of endogenous and exogenous infection after irradiation. Journ of Antimicrobial Chemotherapy, 33, 777-784.
6. Brook, I., Tom, S. and Ledney, G. D., 1993, Quinolone and glycopeptide therapy for infection in mouse following exposure to mixed-field neutron-γ-photon radiation. International Journal of Radiation Biology, 64, 771-777.
7. Brown, D. O., Graham, W. J., III, MacKenzie, L. J., Pittock, J. W., III and Shaw, L. J., 1988, Can WR-2721 be improved upon? In Perspectives in Radioprotection. edited by J. F. Weiss and M. G. Simic (New York: Pergamon Press), Pharmacology and Therapeutics, 39, 157-168.
8. Cagnoni, P. J., Jones, R. B., Bearman, S. I., Ross, M., Hami, L., Franklin, W. A., Capizzi, R., Schein, P. S. and Shpall, E. J., 1996, Use of amifostine in bone marrow purging. Seminars in Oncology, 23 (Suppl. 8), 44-48.
9. Capizzi, R. L., 1996, The preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies by amifostine (Ethyol). European Journal of Cancer, 32A (Suppl. 4), S4 S16.
10. Capizzi, R. L., Scheffler, B. J. and Schein, P. S., 1993, Amifostine-mediated protection of normal bone marrow from cytotoxic chemotherapy. Cancer, 72 (Suppl. 11), 3495 3501.
11. Carter, R. E. and Verrelli, D. M., 1973, AFRRI cobalt whole-body irradiation. Technical Note 73-3 (Bethesda, MD: Armed Forces Radiobiology Research Institute).
12. Debell, R. M., Ledney, G. D. and Snyder, S. L., 1987, Quantification of gut injury with diamine oxidase activity: development of a fission neutron RBE and measurements with combined injury in mouse models. Radiation Research, 112, 508-516.
13. Douay, L., Hu, C., Giarratana, M. C., Bouchet, S., Conlon, J., Capizzi, R. L. and Gorin, N. C., 1995, Amifostine improves the antileukemic therapeutic index of mafosfamide: implications for bone marrow purging. Blood, 86, 2849-2855.
14. Eisenhauer, C. M., 1991, AFRRI Neutron Spectrum Directory (Gaithersburg, MD: National Institute of Standards and Technology).
15. Elliott, T. B., Ledney, G. D., Harding, R. A., Henderson, P. L., Gerstenberg, H. M., Rotruck, J. R., Verdolin, M. H., Stille, C. M. and Kreiger, A. G., 1995, Mixed-field neutrons and γ-photons induce different changes in ileal bacteria and correlated sepsis in mice. International Journal of Radiation Biology, 68, 311-320.
16. Ferlic, K. P. and Zeman, G. H., 1983, Spectrum-averaged kerma factors for reactor dosimetry with paired ion chambers. Technical Report TR83-4 (Bethesda, MD: Armed Forces Radiobiology Research Institute).
17. Field, S. B. and Hornsey, S., 1975, The RBE for fast neutrons: the link between animal experiments and clinical practice. In Radiation Research; Biomedical, Chemical and Physical Perspectives, Proceedings of the 5th International Congress on Radiation Research, Seattle, WA, July 14-20, 1974, edited by O. F. Nygaard, H. I. Adler and W. K. Sinclair (New York: Academic Press), pp. 1125 1135.
18. Finney, D. J., 1971, Probit Analysis, 3rd edition (New York: Cambridge University Press), pp. 1-99.
19. Finney, D.J., 1979, Statistical Method in Biological Assay, 3rd edition (New York: MacMillan), pp. 370-379.
20. Fleiss, J. L., 1986, The Design and Analysis of Clinical Experiments (New York: John Wiley & Sons), pp. 130 132.
21. Gerstenberg, H. M., 1991, Comparison of y spectra from the TRIGA and JANUS reactors: the implication for dose-rate studies. In Radiation Research: A Twentieth-century Perspective, edited by J. D. Chapman, W. C. Dewey and G. F. Whitmore (San Diego: Academic Press), p. 110.
22. Gerstenberg, H. M., Bhatt, R. C., Torres, B. A. and Bolds, K. D., 1997, Use of microdosimetry for mixed-field radiation measurements at the AFRRI TRIGA reactor. In Microdosimetry: An Interdisciplinary Approach, edited by D. T. Goodhead, P. O'Neil and H. G. Menzel (Cambridge: Royal Society of Chemistry), pp. 357-360.
23. Grdina, D. J., Carnes, B. A. and Nagy, B., 1992, Protection by WR-2721 and WR-151327 against late effects of gamma rays and neutrons. Advances in Space Research, 12, 257-263.
24. Grdina, D.J., Wright, B.J. and Carnes, B. A., 1991, Protection by WR-151327 against late-effect damage from fission-spectrum neutrons. Radiation Research, 128, S124 S127.
25. Green, D., Bensley, D. and Schein, P., 1994, Preclinical evaluation of WR-151327: an orally active chemotherapy protector. Cancer Research, 54, 738-741.
26. Hendry, J. H., Potten, G. S. and Merritt, A., 1995, Apoptosis induced by high-and low-LET radiations. Radiation and Environmental Biophysics, 34, 59-62.
27. Institute of Laboratory Animal Resources, Commission on Life Sciences, 1996, Guide for The Care and Use of Laboratory Animals (Washington, DC, National Research Council: National Academy Press), 125 pp.
28. Kemp, G., Rose, P., Lurain, J., Berman, M., Manetta, A., Roullet, B., Homesley, H., Belpomme, D. and Glick, J., 1996, Amifostine pretreatment for protection against cyclophosphamide-induced and cisplatin-induced toxicities: resutls of a randomized control trial in patients with advanced ovarian cancer. Journal of Clinical Oncology, 14, 2101-2112.
29. Landauer, M. R., Hogan, J. B., Castro, C. A., Benson, K. A., Shehata, C. W. and Weiss, J. F., 1996, Behavioral toxicity and radioprotective efficacy of WR-151327 in combination with adenosine receptor antagonists. In Proceedings of the 1995 ERDEC Conference on Chemical and Biologicval Defense Research, ERDEC-SP-043, edited by D. A. Berg (Aberdeen Provine Ground, MD: Research and Technology Directorate, US Army Chemical and Biological Defense Command), pp. 535-541.
30. Ledney, G. D., Elliott, T. B., Landauer, M. R., Vigneulle, R. M., Henderson, P. L., Harding, R. A. and Tom, S. P., Jr, 1994, Survival of irradiated mice treated with WR-151327, synthetic trehalose dicorynomycolate, or ofloxacin. Advances in Space Research, 14, 583-586.
31. Ledney, G. D., Harding, R. A., Elliott, T. B., Henderson, P. L., Baker, W. H. and Zmuda, J. A., 1996, Survival enhancement and infection in mouse models of injury associated with radiation disasters. In 'Advances in the Treatment of Radiation Injuries. Proceedings of the 2nd Consensus Development Conference on the Treatment of Radiation Injuries, Bethesda, MD, April 14-17, 1993', edited by T. J. MacVittie, J. F. Weiss and D. Browne (New York: Pergamon Press), Advances in the Biosciences, 94, 183-186.
32. Ledney, G. D., Madonna, G. S., Elliott, T. B., Moore, M. M. and Jackson, W. E., III, 1991, Therapy of infections in mice irradiated in mixed neutron/photon fields and inflicted with wound trauma: a review of current work. Radiation Research, 128, S18-S28.
33. Lee, E. T., 1979, Statistical Method in Biological Assay, 3rd edition (New York: MacMillan), pp. 370-379.
34. List, A. F., Brasfield, F., Heaton, R., Glinsmann-Gibson, B., Crook, L., Taetle, R. and Capizzi, R., 1997, Stimulation of hematopoiesis by amifostine in patients with myelodysplastic syndrome. Blood, 90, 3364-3369.
35. List, A. F., Heaton, R., Glinsman-Gibson, R. and Capizzi, R. L., 1996, Amifostine protects primitive hematopoietic progenitors against chemotherapy cytotoxicity. Seminars in Oncology, 23 (Suppl. 8), pp. 58-63.
36. MacVittie, T. J., 1979, Alterations induced in macrophage and granulocyte-macrophage colony forming cells by a single injection of mice with Corynbacterium parvum. Journal of the Reticuloendothelial Society, 26, 479 490.
37. Madonna, G. S., Ledney, G. D., Elliott, T. B., Brook, I., Ulrich, J. T., Myers, K. R., Patchen, M. L. and Walker, R. I., 1989, Trehalose dimycolate enhances resistance to infection in neutropenic animals. Infection and Immunity, 57, 2495-2501.
38. McChesney, D. G., Ledney, G. D. and Madonna, G. S., 1990, Trehalose dimycolate enhances survival of fission neutron-irradiated mice and Klebsiella pneumoniae-challenged irradiated mice. Radiation Research, 121, 71-75.
39. Myska, J. C., Adams, T. L., Bhatt, R. C., Broom, J. G., Pitcher, C. D., Sharpnack, F. M., II, St. John, T. J., Torres, B. A., Vavrina, G. and Gerstenberg, H. M., 1997, Arrays for use at the cobalt irradiation facility. Technical report 97-2 (Bethesda, MD: Armed Forces Radiobiology Research Institute).
40. Patchen, M. L., 1994, Single and combination cytokine therapies for the treatment of radiation-induced hemopoietic injury. In 'Advances in the Treatment of Radiation Injuries. Proceedings of the 2nd Consensus Development Conference on the Treatment of Radiation Injuries, Bethesda, MD, April 14 17, 1993', edited by T. J. MacVittie, J. F. Weiss and D. Browne (New York: Pergamon Press), Advances in the Biosciences, 94, 21-36.
41. Patchen, M. L., 1995, Amifostine plus granulocyte colony-stimulating factor therapy enhances recovery from supra-lethal radiation exposures: preclinical experience in animal models. European Journal of Cancer, 31A (Suppl. 1), S17 S21.
42. Patchen, M. L. and MacVittie, T. J., 1994, Granulocyte colony-stimulating factor and amifostine (Ethyol) synergize to enhance hemopoietic reconstitution and increase survival in irradiated animals. Seminars in Oncology, 21, 26-32.
43. Peterson, V. M., Adamovicz, J. H., Elliott, T. B., Moore, M. M., Madonna, G. S., Jackson, W. E., III, Ledney, G. D. and Gause, W. C., 1994, Gene expression of hemato-regulatory cytokines is elevated endogenously after sublethal gamma irradiation and is differentially enhanced by therapeutic administration of biologic response modifiers. The Journal of Immunology, 153, 2321-2330.
44. Philips, T. L. and Fu, K. K., 1976, Biological effects of 15MeV neutrons. International Journal of Radiation Oncology, Biology, Physics, 1, 1139-1147.
45. Ramnath, N., LoRusso, P., Simon, M. and Martino, S., 1997, Phase II evaluation of cisplatin and WR2721 for refractory metastatic breast cancer. American Journal of Clinical Oncology, 20, 368-372.
46. Ryan, S. V., Carrithers, S. L., Parkinson, S. J., Skurk, C., Nuss, C., Pooler, R. M., Owen, C. S., Lefer, A. M. and Waldman, S. A., 1996, Hypotensive mechanisms of amifostine. Journal of Clinical Pharmacology, 36, 365-373.
47. Savoye, C., Swenberg, C., Hugot, S., Sy, D., Sabattier, R., Charlier, M. and Spotheim-Maurizot, M., 1997, Thiol WR-1065 and disulphide WR-33278, two metabolites of the drug Ethyol (WR-2721), protect DNA against fast neutron-induced strand breakage. International Journal of Radiation Biology, 71, 193-202.
48. Sigdestad, C. P., Connor, A. M. and Sims, C. S., 1992, Modification of neutron-induced hematopoietic effects by chemical radioprotectors. International Journal of Radiation Oncology, Biology, Physics, 22, 807-811.
49. 60Co by WR-2721 and WR-151327. Radiation Research, 106, 224-233.
50. Steel, L. K., Jacobs, A. K., Giambarresi, L. I. and Jackson, W. E., III, 1987. Protection of mice against fission neutron irradiation by WR-2721 or WR-151327. Radiation Research, 109, 469 478.
51. Steel-Goodwin, L., Kendrick, J. M., Egan, J. E. and Eckstein, J. M., 1992, Pathological evaluation of WR-151327 administered orally in irradiated and non-irradiated male mice. Annals of Clinical and Laboratory Science, 22, 182 188.
52. Sweeney, T. R., 1979, A survey of compounds from the antiradiation drug development program of the U.S. Army Medical Research and Development Command (Washington, DC: Walter Reed Army Institute of Research).
53. Swenberg, C. E., Vaishnav, Y. N., Li, B., Tsao, H., Mao B. and Geacintov, N. E., 1997, Single-strand breaks in oligodeoxyribonucleotides induced by fission neutrons and gamma radiation and measured by gel electrophoresis: protective effects of aminothiols. Journal of Radiation Research, 38, 241-254.
54. Sy, D., Durand, C., Hugot, S., Savoye, C., Swenberg, C., Charlier, M. and Spotheim-Maurizot, M., 1999, Sequence dependence of DNA radioprotection by the thiols WR-1065 and WR-171326. Theoretical Chemistry Accounts, 101, 114 120.
55. Torres, B. A., Bhatt, R. C., Myska, J. C. and Holland, B. K., 1996, Determination of canine dose conversion factors in mixed neutron and gamma radiation fields. Technical Report 96-2 (Bethesda, MD: Armed Forces Radiobiology Research Institute).
56. Van der Vijgh, W. J. and Peters, G. J., 1994, Protection of normal tissues from the cytotoxic effects of chemotherapy and radiation by amifostine (Ethyol): preclinical aspects. Seminars in Oncology, 21 (5 Suppl. 11), 2-11.