메뉴 건너뛰기




Volumn 78, Issue 6, 2000, Pages 483-489

Molecular mechanism of doxorubicin-induced anticholinergic effect in guinea-pig atria

Author keywords

Action potential duration; Anticholinergic action; Atrial cell; Doxorubicin; The muscarinic acetylcholine receptor operated K+ current

Indexed keywords

DOXORUBICIN;

EID: 0033949532     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y00-013     Document Type: Article
Times cited : (2)

References (38)
  • 2
    • 0017640687 scopus 로고
    • Plasma pharmacokinetics of adriamycin and its metabolites in humans with normal hepatic and renal function
    • Benjamin, R.S., Riggs, C.R. Jr., and Bachur, N.R. 1977. Plasma pharmacokinetics of adriamycin and its metabolites in humans with normal hepatic and renal function. Cancer Res. 37: 1416-1420.
    • (1977) Cancer Res. , vol.37 , pp. 1416-1420
    • Benjamin, R.S.1    Riggs C.R., Jr.2    Bachur, N.R.3
  • 3
    • 0024560588 scopus 로고
    • The molecular basis of muscarinic receptor diversity
    • Bonner, T.I. 1989. The molecular basis of muscarinic receptor diversity. Trends Neurol. Sci. 12: 148-151.
    • (1989) Trends Neurol. Sci. , vol.12 , pp. 148-151
    • Bonner, T.I.1
  • 4
    • 0022350208 scopus 로고
    • Uncoupling of cardiac muscarinic and β-adrenergic receptors from ion channels by a guanine nucleotide analogue
    • Breitwieser, G.E., and Szabo, G. 1985. Uncoupling of cardiac muscarinic and β-adrenergic receptors from ion channels by a guanine nucleotide analogue. Nature (London), 317: 538-540.
    • (1985) Nature (London) , vol.317 , pp. 538-540
    • Breitwieser, G.E.1    Szabo, G.2
  • 5
    • 0021922795 scopus 로고
    • Improved high-performance liquid chromatography assay of doxorubicin: Detection of circulating aglycones in human plasma and comparison with thin layer chromatography
    • Brenner, D.E., Galloway, S., Cooper, J., Noone, R., and Hande, K.R. 1985. Improved high-performance liquid chromatography assay of doxorubicin: detection of circulating aglycones in human plasma and comparison with thin layer chromatography. Cancer Chemother. Pharmacol. 14: 139-145.
    • (1985) Cancer Chemother. Pharmacol. , vol.14 , pp. 139-145
    • Brenner, D.E.1    Galloway, S.2    Cooper, J.3    Noone, R.4    Hande, K.R.5
  • 6
    • 0019501351 scopus 로고
    • Dose-effect and structure-function relationships in doxorubicin cardiomyopathy
    • Bristow, M.R., Mason, J.W., Billingham, M.E., and Daniels, J.R. 1981. Dose-effect and structure-function relationships in doxorubicin cardiomyopathy. Am. Heart J. 102: 709-718.
    • (1981) Am. Heart J. , vol.102 , pp. 709-718
    • Bristow, M.R.1    Mason, J.W.2    Billingham, M.E.3    Daniels, J.R.4
  • 8
    • 0022560536 scopus 로고
    • Desensitization of the acetylcholine induced increase of potassium conductance in rabbit cardiac Purkinje fibres
    • Carmeliet, E., and Mubagwa, K. 1986. Desensitization of the acetylcholine induced increase of potassium conductance in rabbit cardiac Purkinje fibres. J. Physiol. (London), 371: 239-255.
    • (1986) J. Physiol. (London) , vol.371 , pp. 239-255
    • Carmeliet, E.1    Mubagwa, K.2
  • 9
    • 0021875819 scopus 로고
    • Effects of doxorubicin and verapamil on calcium uptake in primary cultures of rat myocardial cells
    • Combs, A.B., Acosta, D., and Ramos, K. 1985. Effects of doxorubicin and verapamil on calcium uptake in primary cultures of rat myocardial cells. Biochem. Pharmacol. 34: 1115-1116.
    • (1985) Biochem. Pharmacol. , vol.34 , pp. 1115-1116
    • Combs, A.B.1    Acosta, D.2    Ramos, K.3
  • 10
    • 0026078494 scopus 로고
    • Doxorubicin-induced cardiac toxicity
    • Doroshow, J.H. 1991. Doxorubicin-induced cardiac toxicity. New Eng. J. Med. 324: 843-845.
    • (1991) New Eng. J. Med. , vol.324 , pp. 843-845
    • Doroshow, J.H.1
  • 11
    • 0017253191 scopus 로고
    • Adriamycin: Energy metabolism and mitochondrial oxidations in the heart of treated rabbits
    • Ferrero, M.E., Ferrero, E., Gaja, G., and Bernelli-Zazzera, A. 1976. Adriamycin: energy metabolism and mitochondrial oxidations in the heart of treated rabbits. Biochem. Pharmacol. 25: 125-130.
    • (1976) Biochem. Pharmacol. , vol.25 , pp. 125-130
    • Ferrero, M.E.1    Ferrero, E.2    Gaja, G.3    Bernelli-Zazzera, A.4
  • 12
    • 85047675810 scopus 로고
    • Activity of receptors coupled to guanine nucleotide binding regulatory protein in doxorubicin induced cardiomyopathy
    • Fu, L.-X., Sjögren, K.-G., and Liang, Q.-M., Waagstein, F., Hoebeke, J., and Hjalmarson, Å. 1991. Activity of receptors coupled to guanine nucleotide binding regulatory protein in doxorubicin induced cardiomyopathy. Cardiovasc. Res. 25: 145-150.
    • (1991) Cardiovasc. Res. , vol.25 , pp. 145-150
    • Fu, L.-X.1    Sjögren, K.-G.2    Liang, Q.-M.3    Waagstein, F.4    Hoebeke, J.5    Hjalmarson, Å.6
  • 13
    • 0030804864 scopus 로고    scopus 로고
    • Analyses of the molecular mechanism of adriamycin-induced cardiotoxicity
    • Gille, L., and Nohl, H. 1997. Analyses of the molecular mechanism of adriamycin-induced cardiotoxicity. Free Radical Biol. Med. 23: 775-782.
    • (1997) Free Radical Biol. Med. , vol.23 , pp. 775-782
    • Gille, L.1    Nohl, H.2
  • 14
    • 0017393733 scopus 로고
    • Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin
    • Goodman, J., and Hochstein, P. 1977. Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin. Biochem. Biophys. Res. Commun. 77: 797-803.
    • (1977) Biochem. Biophys. Res. Commun. , vol.77 , pp. 797-803
    • Goodman, J.1    Hochstein, P.2
  • 15
    • 0018383419 scopus 로고
    • Inhibition of sodium potassium-activated adenosine 5'-triphosphatase and ion transport by adriamycin
    • Gosalvez, M., Van Rossum, G.D., and Blanco, M.F. 1979. Inhibition of sodium potassium-activated adenosine 5'-triphosphatase and ion transport by adriamycin. Cancer Res. 39: 257-261.
    • (1979) Cancer Res. , vol.39 , pp. 257-261
    • Gosalvez, M.1    Van Rossum, G.D.2    Blanco, M.F.3
  • 16
    • 0028790285 scopus 로고
    • SD-3212, a new class I and IV antiarrhythmic drug: A potent inhibitor of the muscarinic acetylcholine-receptor-operated potassium current in guinea-pig atrial cells
    • Hara, Y., and Nakaya, H. 1995. SD-3212, a new class I and IV antiarrhythmic drug: a potent inhibitor of the muscarinic acetylcholine-receptor-operated potassium current in guinea-pig atrial cells. Br. J. Pharmacol. 116: 2750-2756.
    • (1995) Br. J. Pharmacol. , vol.116 , pp. 2750-2756
    • Hara, Y.1    Nakaya, H.2
  • 18
    • 0030050907 scopus 로고    scopus 로고
    • Acute presynaptic inhibition by doxorubicin of negative chrono- and inotropic responses to parasympathetic nerve stimulation in isolated, blood-perfused dog atrium
    • Hoyano, Y., Furukawa, Y., Oguchi, T., Kasama, M., Imamura, H., and Chiba, S. 1996. Acute presynaptic inhibition by doxorubicin of negative chrono-and inotropic responses to parasympathetic nerve stimulation in isolated, blood-perfused dog atrium. J. Cardiovasc. Pharmacol. 27: 37-41.
    • (1996) J. Cardiovasc. Pharmacol. , vol.27 , pp. 37-41
    • Hoyano, Y.1    Furukawa, Y.2    Oguchi, T.3    Kasama, M.4    Imamura, H.5    Chiba, S.6
  • 19
    • 0027506801 scopus 로고
    • Antiarrythmic agents act differently on the activation phase of the ACh-response in guinea-pig atrial myocytes
    • Inomata, N., Ohno, T., Ishihara, T., and Akaike, N. 1993. Antiarrythmic agents act differently on the activation phase of the ACh-response in guinea-pig atrial myocytes. Br. J. Pharmacol. 108: 111-115.
    • (1993) Br. J. Pharmacol. , vol.108 , pp. 111-115
    • Inomata, N.1    Ohno, T.2    Ishihara, T.3    Akaike, N.4
  • 21
    • 0022636517 scopus 로고
    • Doxorubicin cardiotoxicity: Contractile changes after long-term treatment in the rat
    • Jensen, R.A. 1986. Doxorubicin cardiotoxicity: contractile changes after long-term treatment in the rat. J. Pharmacol. Exp. Ther. 236: 197-203.
    • (1986) J. Pharmacol. Exp. Ther. , vol.236 , pp. 197-203
    • Jensen, R.A.1
  • 23
    • 0024409541 scopus 로고
    • Doxorubicin-induced calcium release from cardiac sarcoplasmic reticulum vesicles
    • Kim, D.-H., Landry III, A.B., Lee, Y.S., and Katz, A.M. 1989. Doxorubicin-induced calcium release from cardiac sarcoplasmic reticulum vesicles. J. Mol. Cell. Cardiol. 21: 433-436.
    • (1989) J. Mol. Cell. Cardiol. , vol.21 , pp. 433-436
    • Kim, D.-H.1    Landry A.B. III2    Lee, Y.S.3    Katz, A.M.4
  • 25
    • 0022515173 scopus 로고
    • + channels by adenosine in isolated atrial cells: Involvement of GTP-binding proteins
    • + channels by adenosine in isolated atrial cells: involvement of GTP-binding proteins. Pflügers Arch. 407: 264-274.
    • (1986) Pflügers Arch. , vol.407 , pp. 264-274
    • Kurachi, Y.1    Nakajima, T.2    Sugimoto, T.3
  • 26
    • 0023484624 scopus 로고
    • + channel current in isolated atrial myocytes and possible role of GTP-binding proteins
    • + channel current in isolated atrial myocytes and possible role of GTP-binding proteins. Pflügers Arch. 410: 227-233.
    • (1987) Pflügers Arch. , vol.410 , pp. 227-233
    • Kurachi, Y.1    Nakajima, T.2    Sugimoto, T.3
  • 27
  • 28
    • 0017649905 scopus 로고
    • Inhibition of the cardiac mitochondrial calcium pump by adriamycin in vitro
    • Moore, L., Landon, E.J., and Cooney, D.A. 1977. Inhibition of the cardiac mitochondrial calcium pump by adriamycin in vitro. Biochem. Med. 18: 131-138.
    • (1977) Biochem. Med. , vol.18 , pp. 131-138
    • Moore, L.1    Landon, E.J.2    Cooney, D.A.3
  • 29
    • 0029057635 scopus 로고
    • Anticholinergic effects of class III antiarrhythmic drugs in guinea-pig atrial cells. Different molecular mechanisms
    • Mori, K., Hara, Y., Saito, T., Masuda, Y., and Nakaya, H. 1995. Anticholinergic effects of class III antiarrhythmic drugs in guinea-pig atrial cells. Different molecular mechanisms. Circulation, 91: 2834-2843.
    • (1995) Circulation , vol.91 , pp. 2834-2843
    • Mori, K.1    Hara, Y.2    Saito, T.3    Masuda, Y.4    Nakaya, H.5
  • 30
    • 0030899485 scopus 로고    scopus 로고
    • Abnormal β-adrenergic transmembrane signaling in rabbits with adriamycin-induced cardiomyopathy
    • Nagami, K., Yoshikawa, T., Suzuki, M., Wainai, Y., Anzai, T., and Handa, S. 1997. Abnormal β-adrenergic transmembrane signaling in rabbits with adriamycin-induced cardiomyopathy. Jpn. Circ. J. 61: 249-255.
    • (1997) Jpn. Circ. J. , vol.61 , pp. 249-255
    • Nagami, K.1    Yoshikawa, T.2    Suzuki, M.3    Wainai, Y.4    Anzai, T.5    Handa, S.6
  • 31
    • 0024593814 scopus 로고
    • Anticholinergic effects of quinidine, disopyramide, and procainamide in isolated atrial myocytes: Mediation by different molecular mechanisms
    • Nakajima, T., Kurachi, Y., Ito, H., Takikawa, R., and Sugimoto, T. 1989. Anticholinergic effects of quinidine, disopyramide, and procainamide in isolated atrial myocytes: mediation by different molecular mechanisms. Cir. Res. 64: 297-303.
    • (1989) Cir. Res. , vol.64 , pp. 297-303
    • Nakajima, T.1    Kurachi, Y.2    Ito, H.3    Takikawa, R.4    Sugimoto, T.5
  • 32
    • 0025051505 scopus 로고
    • Doxorubicin cardiotoxicity: Analysis of prevailing hypotheses
    • Olson, R.D., and Mushlin, P.S. 1990. Doxorubicin cardiotoxicity: analysis of prevailing hypotheses. FASEB J. 4: 3076-3086.
    • (1990) FASEB J. , vol.4 , pp. 3076-3086
    • Olson, R.D.1    Mushlin, P.S.2
  • 33
    • 0025168802 scopus 로고
    • Biphasic effects of doxorubicin on the calcium release channel from sarcoplasmic reticulum of cardiac muscle
    • Ondrias, K., Borgatta, L., Kim, D.-H., and Ehrlich, B.E. 1990. Biphasic effects of doxorubicin on the calcium release channel from sarcoplasmic reticulum of cardiac muscle. Circ. Res. 67: 1167-1174.
    • (1990) Circ. Res. , vol.67 , pp. 1167-1174
    • Ondrias, K.1    Borgatta, L.2    Kim, D.-H.3    Ehrlich, B.E.4
  • 36
    • 0027446904 scopus 로고
    • Comparison of cardiac actions of doxorubicin, pirarubicin and aclarubicin in isolated guinea-pig heart
    • Temma, K., Akera, T., Chugun, A., Kondo, H., Hagane, K., and Hirano, S. 1993. Comparison of cardiac actions of doxorubicin, pirarubicin and aclarubicin in isolated guinea-pig heart. Eur. J. Pharmacol. 234: 173-181.
    • (1993) Eur. J. Pharmacol. , vol.234 , pp. 173-181
    • Temma, K.1    Akera, T.2    Chugun, A.3    Kondo, H.4    Hagane, K.5    Hirano, S.6
  • 37
    • 0030612062 scopus 로고    scopus 로고
    • 2+ overloading causes the negative inotropic effect of doxorubicin in myocytes isolated from guinea-pig heart
    • 2+ overloading causes the negative inotropic effect of doxorubicin in myocytes isolated from guinea-pig heart. Eur. J. Pharmacol. 322: 235-242.
    • (1997) Eur. J. Pharmacol. , vol.322 , pp. 235-242
    • Temma, K.1    Chugun, A.2    Akera, T.3    Hara, Y.4    Sasaki, T.5    Kondo, H.6
  • 38
    • 0028348651 scopus 로고
    • Molecular mechanism of cibenzoline-induced anticholinergic action in single atrial myocytes: Comparison with effect of disopyramide
    • Wu, S.N., Nakajima, T., Yamashita, T., Hamada, E., Hazama, H., Iwasawa, K., Omata, M., and Kurachi, Y. 1994. Molecular mechanism of cibenzoline-induced anticholinergic action in single atrial myocytes: comparison with effect of disopyramide. J. Cardiovasc. Pharmacol. 23: 618-623.
    • (1994) J. Cardiovasc. Pharmacol. , vol.23 , pp. 618-623
    • Wu, S.N.1    Nakajima, T.2    Yamashita, T.3    Hamada, E.4    Hazama, H.5    Iwasawa, K.6    Omata, M.7    Kurachi, Y.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.