3He-MRI-based measurements of intrapulmonary p(O2) and its time course during apnea in healthy volunteers: First results, reproducibility, and technical limitations

NMR in Biomedicine

Volumn 13, Issue 4, 2000, Pages 194-201

  Deninger, Anselm J ^a   Eberle, Balthasar ^a   Ebert, Michael ^a   Grossmann, Tino ^a   Hanisch, Gorden ^a   Heil, Werner ^a   Kauczor, Hans Ulrich ^a   Markstaller, Klaus ^a   Otten, Ernst ^a   Schreiber, Wolfgang ^a   Surkau, Reinhard ^a   Weiler, Norbert ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Apnea; Humans; Hyperpolarized gases; Lung function; Magnetic resonance imaging; Oxygen partial pressure

Indexed keywords

HELIUM;

ADULT; APNEA; APPARATUS; ARTICLE; BREATH HOLDING; DEPOLARIZATION; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPERPOLARIZATION; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN TENSION; PRIORITY JOURNAL;

ADULT; APNEA; FEMALE; HELIUM; HUMANS; ISOTOPES; MAGNETIC RESONANCE IMAGING; MALE; OXYGEN; PARTIAL PRESSURE; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; RESPIRATORY FUNCTION TESTS; RESPIRATORY MECHANICS;

EID: 0033945191     PISSN: 09523480     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-1492(200006)13:4<194::AID-NBM643>3.0.CO;2-D     Document Type: Article

References (23)

1. Nunn JF. 1993. Nunn's Applied Respiratory Physiology, 4th edn, Butterworth Heinemann, Oxford.
2. Riley RL, Lilienthal JL, Proemmel DD and Franke RE. 1946. On the determination of the physiologically effective pressures of oxygen and carbon dioxide in alveolar air. Am. J. Physiol. 147: 191-198.
3. Morrell NW, Wignail BK, Biggs T and Seed WA. 1994. Collateral ventilation and gas exchange in emphysema. Am. J. Crit. Care Med. 150: 635-641.
4. Bachert P, Schad LR, Bock M, Knopp MV, Ebert M, Großmann T, Heil W, Hofmann D, Surkau R and Otten EW. 1996. Nuclear magnetic resonance imaging of airways in humans with use of hyperpolarized 3He. Magn. Res. Med. 36: 192-196.
5. Chen XJ, Chawla MS, Hedlund LW, Möller HE, MacFall JR and Johnson GA. 1998. MR microscopy of lung airways with hyperpolarized 3He. Magn. Res. Med. 39: 79-84.
6. Viallon M, Cofer GP, Suddarth SA, Möller HE, Chen XJ, Chawla MS, Hedlund LW, Crémillieux Y and Johnson GA. 1999. Functional MR microscopy of the lung using hyperpolarized 3He. Magn. Res. Med. 41: 787-792.
7. Ebert M, Großmann T, Heil W, Otten EW, Surkau R, Leduc M, Bachert P, Knopp MV, Schad LR and Thelen M. 1996. Nuclear magnetic resonance imaging with hyperpolarized 3He. Lancet 347: 1297-1299.
8. MacFall JR, Charles HC, Black RD, Middleton H, Swartz JC, Saam B, Driehuys B, Erickson C, Happer W, Cates GD, Johnson GA and Ravin CE. 1996. Human lung air spaces: potential for MR imaging with hyperpolarized 3He. Radiology 200: 553-558.
9. Darrasse L, Guillot G, Nacher PJ and Tastevin G. 1997. Low-field 3He nuclear magnetic resonance in human lungs. C. R. Acad. Sci. 324: 691-700.
10. Kauczor H-U, Hofmann D, Kreitner K-F, Nilgens H, Surkau R, Heil W, Pottast A, Knopp M, Otten EW and Thelen M. 1996. Normal and abnormal pulmonary ventilation: Vizualization at hyperpolarized He-3 MR imaging. Radiology 201: 564-568.
11. Kauczor H-U, Ebert M, Kreitner K-F, Nilgens H, Surkau R, Heil W, Hofmann D, Otten EW and Thelen M. 1997. Imaging of the lungs using 3He MRI: preliminary clinical and experience in 18 patients with and without lung disease. J. Magn. Res. Imag. 7: 538-543.
12. De Lange EE, Mugler III JP, Brookeman JR, Knight-Scott J, Truwit JD, Teates CD, Daniel TM, Bogorad PL and Cates GC. 1999. Lung air spaces: MR imaging evaluation with hyperpolarized 3He gas. Radiology 210: 851-857.
13. Saam B, Yablonskiy DA, Gierada DS, Cooper JD, Lefrak SS and Conradi MS. 1999. Measuring diffusivity of 3He in human lung: preliminary study of patients with emphysema. Eur. Radiol. 9: B22.
14. 2. Phys. Rev. A 52: 862-865.
15. 2-concentrations by magnetic resonance imaging of inhaled hyperpolarized 3helium. J. Appl. Physiol. 87: 2043-2052.
16. Deninger AJ, Eberle B, Ebert M, Großmann T, Heil W, Kauczor H-U, Lauer L, Markstaller K, Otten E, Schmiedeskamp J, Schreiber W, Surkau R, Thelen M and Weiler N. 1999. Quantification of regional intrapulmonary oxygen partial pressure evolution during apnea by 3He MRI. J. Magn. Res. 141: 207-216.
17. Eckert G, Heil W, Meyerhoff M, Otten EW, Surkau R, Werner M, Leduc M, Nacher PJ and Schearer LD. 1992. A dense polarized 3He target based on compression of optically pumped gas. Nucl. Instrum. Meth. A 320: 53-65.
18. Becker J, Heil W, Krug B, Leduc M, Meyerhoff M, Nacher PJ, Otten EW, Prokscha Th, Schearer LD and Surkau R. 1994. Study of mechanical compression of spin-polarized 3He gas. Nucl. Instrum. Meth. A 346: 45-51.
19. Surkau R, Becker J, Ebert M, Großmann T, Heil W, Hofmann D, Humblot H, Leduc M, Otten EW, Rohe D, Siemensmeyer K, Steiner M, Tasset F and Trautmann N. 1997. Realization of a broad band neutron spin filter with compressed, polarized 3He gas. Nucl. Instrum. Meth. A 384: 444-450.
20. Gudbjartsson H and Patz S. 1995. The Rician distribution of noisy MRI data. Magn. Res. Med. 34: 910-914.
21. Wagner PD, Laravuso RB, Uhl RR and West JB. 1974. Continuous distribution of ventilation-perfusion ratios in normal subjects breathing air and O2. J. Clin. Invest. 54: 54-68.
22. Staub NC, Bishop JM and Forster RE. 1961. Importance of diffusion and chemical blood cells. J. Appl. Physiol. 16: 511.
23. Brandt L, Mertzlufft F and Dick W. 1989. Verhalten des arteriellen und gemischtvenösen Blutgasstatus in der Initialphase der Intubationsapnoe. Anaesthetist 38: 167-173.