Schistosoma mansoni gene GP22 encodes the tegumental antigen Sm25: (1) Antibodies to a predicted B-cell epitope of Sm25 cross-react with other candidate vaccine worm antigens; (2) characterization of a recombinant product containing tandem-repeats of this peptide as a vaccine

Parasite Immunology

Volumn 22, Issue 8, 2000, Pages 381-395

  Petzke, Mary M ^a   Suri, Parmjeet K ^a   Bungiro, Richard ^a   Goldberg, Miriam ^a   Taylor, Sarah F ^a   Ranji, Sumant ^a   Taylor, Harry ^b   McCray Jr , Joseph W ^b   Knopf, Paul M ^a  

^a BROWN UNIVERSITY   (United States)

^b MOREHOUSE COLLEGE   (United States)

Author keywords

Cross reacting antigens; Expression vector pET15b; Recombinant antigen; Schistosoma mansoni; Sm25; Vaccine

Indexed keywords

ANTIBODY; ANTISERUM; DETERGENT; EPITOPE; GLUCAN SYNTHASE; GLUTATHIONE TRANSFERASE; GLYCOPROTEIN; LECTIN; PARAMYOSIN; PARASITE ANTIGEN; PEPTIDE; RECOMBINANT PROTEIN; SCHISTOSOMA VACCINE;

AFFINITY CHROMATOGRAPHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CERCARIA; CODON; CONTROLLED STUDY; CROSS REACTION; IMMUNOGENETICS; INTRON; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SCHISTOSOMA MANSONI; TANDEM REPEAT; VACCINATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, HELMINTH; ANTIGENS, HELMINTH; B-LYMPHOCYTES; CROSS REACTIONS; EPITOPES, B-LYMPHOCYTE; GENETIC VECTORS; HELMINTH PROTEINS; LECTINS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PEPTIDES; RATS; RATS, INBRED F344; RECOMBINANT PROTEINS; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; TANDEM REPEAT SEQUENCES; VACCINATION; VACCINES, SYNTHETIC;

EID: 0033943067     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.2000.00316.x     Document Type: Article

References (29)

1. Auriault C., Balloul J.-M., Pierce R.J. et al. (1987) Helper T cells induced by a purified 28-kilodalton antigen of Schistosoma mansoni protect rats against infection. Infection and Immunity 55, 1163-1169
2. Auriault C., Gras-Masse H., Wolowczuk I. et al. (1988) Analysis of T and B cell epitopes of the Schistosoma mansoni P28 antigen in the rat model by using synthetic peptides. Journal of Immunology 141, 1687-1694
3. Auriault C., Wolowczuk I., Gras-Masse H. et al. (1991) Review: epitopic characterization and vaccinal potential of peptides derived from a major antigen of Schistosoma mansoni (Sm28 GST). Peptide Research 4, 6-11
4. Balloul J.-M., Grzych J.-M., Pierce R. & Capron A. (1987) A purified 28000 dalton protein from Schistosoma mansoni adult worms protects rats and mice against experimental schistosomiasis. Journal of Immunology 138, 3448-3453
5. Barker R.H. Jr, Srivastava B.S., Suri P., Goldberg M. & Knopf P.M. (1985) Immunoprecipitation analysis of radiolabelled protein antigens biosynthesized in vitro by S. mansoni. I. Identification of antigens uniquely recognized by protective antibodies. Journal of Immunology 134, 1192-1201
6. Bushara H.O., Bashir M.E., Malik K.H. et al. (1993) Suppression of Schistosoma bovis egg production with either glutathione S-transferase or keyhole limpet hemocyanin. Parasite Immunology 15, 383-390
7. Cioli D., Knopf P.M. & Senft A.W. (1977) A study of Schistosoma mansoni transferred into permissive and nonpermissive hosts. International Journal for Parasitology 7, 293-297
8. El-Sherbeini M., Bostian K.A. & Knopf P.M. (1990) Schistosoma mansoni: cloning of antigen gene sequences in Escherichia Coli. Experimental Parasitology 70, 72-84
9. El-Sherbeini M., Ramadan N., Bostian K.A. & Knopf P.M. (1991) Cloning and sequence analysis of the Schistosoma mansoni membrane glycoprotein antigen gene GP22. Molecular and Biomedical Parasitology 49, 83-98
10. Grzych J.M., Capron M., Bazin H. & Capron A. (1982) In vitro and in vivo effector function of rat IgG2a monoclonal anti-S. mansoni antibodies. Journal of Immunology 129, 2739-2743
11. Hamilton J.V., Chiodini P.L., Fallon P.G. & Doenhoff M.J. (1999) Periodate-sensitive immunological cross-reactivity between keyhole limpet hemocyanin (KLH) and serodiagnostic Schistosoma mansoni egg antigens. Parasitology 118, 83-89
12. Knight M., Kelly C., Rodrigues V. et al. (1989) A cDNA clone encoding part of the major 25000-dalton surface membrane antigen of adult Schistosoma mansoni. Parasitology Research 75, 280-286
13. Knopf P.M., Nutman T.B. & Reasoner J.A. (1977) Schistosoma mansoni: resistance to reinfection in the rat. Experimental Parasitology 41, 74-82
14. Ko A.I. & Harn D.A. Jr (1987) Characterization of protective and non-protective surface membrane carbohydrate epitopes of Schistosoma mansoni. Memorias Do Instituto Oswald Cruz 82 (Suppl. 4), 115-119
15. Mangold B.L. & Knopf P.M. (1981) Host-protective humoral immune response to Schistosoma mansoni infections in the rat: kinetics of hyperimmune serum-dependent sensitivity and elimination of schistosomes in a passive transfer system. Parasitology 83, 559-574
16. Maniatis T., Fritsch E.F. & Sambrook J. (1982) Molecular Cloning: a Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring, Harbor, NY
17. Mark H.F.L., El-Sherbeini M., Goldberg M. et al. (1991) Schistosoma mansoni: two-dimensional gel electrophoretic analysis of antigens uniquely recognized by protective antibodies. Experimental Parasitology 72, 294-305
18. McCray J.W. Jr & Werner G. (1989) Production and properties of site-specific antibodies to synthetic peptide antigens related to potential cell surface receptor sites for rhinovirus. Methods in Enzymology 178, 676-692
19. Omer-Ali P., Jeffs S.A., Meadows H. et al. (1991) Structure of Sm25, an antigenic integral membrane glycoprotein of adult Schistosoma mansoni. Molecular and Biochemical Parasitology 45, 215-222
20. Panaccio M., Wilson L.R., Crameri S.L., Wijffels G.L. & Spithill T.W. (1992) Molecular characterization of cDNA sequences encoding glutathione S-transferases of Fasciola hepatica. Experimental Parasitology 74, 232-237
21. Pearce E.J., James S.L., Dalton J. et al. (1986) Immunochemical characterization and purification of Sm-97, a Schistosoma mansoni antigen monospecifically recognized by antibodies from mice protectively immunized with a nonliving vaccine. Journal of Immunology 137, 3593-3600
22. Pearce E.J., James S.L., Hieny S., Lanar D.E. & Sher A. (1988) Induction of protective immunity against Schistosoma mansoni by vaccination with schistosome paramyosin (Sm97), a nonsurface parasite antigen. Proceedings of the National Academy of Science USA 85, 5678-5682
23. Petzke M.M. (1996) Immunological Characterization of a 47-amino acid Segment of a Candidate Vaccine Schistosome Antigen, PhD Thesis, Brown University
24. Riveau, G.J. & Capron, A (1997) In New Generatrion Vaccines, 2 edn, eds Levine, M.M., Woodrow, G.C., Kaper, J.B. & Cobon, G.S., pp. 1081-1093, Marcel Dekker, Inc., New York
25. Smithers S.R., Hackett F., Omer-Ali P. & Simpson A.J.G. (1989) Protective immunization of mice against Schistosoma mansoni with purified adult worm surface membranes. Parasite Immunology 11, 301-318
26. Suri P.K., Goldberg M., Madikizela M. et al. (1997) Evaluation of recombinant protein r140, a polypeptide segment of tegumental glycoprotein Sm25, as a defined antigen vaccine against Schistosoma mansoni. Parasite Immunology 19, 515-529
27. Thors C. & Linder E. (1998) Cross-reacting antibodies against keyhole limpet hemocyanin may interfere with the diagnostics of acute schistosomiasis. Parasite Immunology 20, 489-496
28. Torian B.E., Flores B.M., Stroeher V.L., Hagen F.S. & Stamm W.E. (1990) cDNA sequence analysis of a 29-kD cysteine-rich surface antigen of pathogenic Entamoeba histolytica. Proceedings of the National Academy of Science USA 87, 6358-6362
29. Wolowczuk I., Auriault C., Bossus M. et al. (1991) Antigenicity and immunogenicity of a multiple peptidic construction of the Schistosoma mansoni Sm-28 GST antigen in rat, mouse and monkey. 1. Partial protection of Fischer rat after active immunization. Journal of Immunology 146, 1987-1995