'New' active steroids and an unforeseen mechanism of action;De nouvelles activites steroides. Un mecanisme d'action inattendu

Comptes Rendus de l'Academie des Sciences - Serie III

Volumn 323, Issue 6, 2000, Pages 513-518

  Baulieu, Étienne Émile ^a  

^a INSERM   (France)

Author keywords

MAP2; Microtubules; Neurosteroids; Pregnenolone; Steroid action; Tubulin

Indexed keywords

MICROTUBULE ASSOCIATED PROTEIN 2; MONOCLONAL ANTIBODY; NEUROTRANSMITTER RECEPTOR; PRASTERONE; PREGNENOLONE; PROGESTERONE; STEROID HORMONE; STEROID RECEPTOR; TUBULIN;

DRUG BINDING; DRUG MECHANISM; HORMONE ACTION; HORMONE BINDING; HORMONE RECEPTOR INTERACTION; IMMUNOHISTOCHEMISTRY; MICROTUBULE; MICROTUBULE ASSEMBLY; NERVE CELL CULTURE; REVIEW;

EID: 0033940165     PISSN: 07644469     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0764-4469(00)00169-4     Document Type: Review

References (23)

1. Finidori-Lepicard J., Schorderet-Slatkine S., Hanoune J., Baulieu E.E. Steroid hormone as regulatory agent of adenylate cyclase. Inhibition by progesterone of the membrane bound enzyme in Xenopus laevis oocytes. Nature. 292:1981;255-256.
2. Baulieu E.E., Robel P. Non-genomic mechanisms of action of steroid hormones, in: Non Reproductive Actions of Sex Steroids. Proc. Ciba Found. Symp. 268:1995;24-42.
3. Baulieu E.E, Robel P, Schumacher M. Neurosteroids: A New Regulatory Function in the Nervous System. 1999;Humana Press, Totowa.
4. Koenig H.L., Schumacher M., Ferzaz B., Do Thi A.N., Ressouches A., Guennoun R., Jung-Testas I., Robel P., Akwa Y., Baulieu E.E. Progesterone synthesis and myelin formation by Schwann cells. Science. 191:1995;1500-1503.
5. Jung-Testas I., Renoir J.M., Gasc J.M., Baulieu E.E. Estrogen-inducible progesterone receptor in primary cultures of rat glial cells. Exp. Cell Res. 193:1991;12-19.
6. Areceptors. Baulieu E.E, Robel P, Schumacher M. Neurosteroids: A New Regulatory Function in the Nervous System. 1999;155-166 Humana Press, Totowa.
7. Gibbs T.T, Yaghoubi N., Weaver C.E., Park-Chung M., Russek S.J., Farb D.H. Modulation of ionotropic glutamate receptors by neuroactive steroids. Baulieu E.E, Robel P, Schumacher. Neurosteroids: A New Regulatory Function in the Nervous System. 1999;167-190 Humana Press, Totowa.
8. 3H] norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus. Proc. Natl. Acad. Sci. USA. 92:1995;3774-3777.
9. Vallée M., Mayo W., Darnaudery M., Corpechot C., Young J., Koehl M., Le Moal M, Baulieu E.E., Robel P., Simon H. Neurosteroids: deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in hippocampus. Proc Natl. Acad. Sci. USA. 94:1997;14865-14870.
10. Robel P., Schumacher, Baulieu E.E. Neurosteroids: from definition and biochemistry to physiopathologie function. Baulieu E.E, Robel P, Schumacher M. Neurosteroids: A New Regulatory Function in the Nervous System. 1999;1-25 Humana Press, Totowa.
11. Murakami K., Fellous A., Baulieu E.E., Robel P. Pregnenolone binds to microtubule-associated protein 2 and stimulates microtubule assembly. Proc. Natl. Acad. Sci. USA. 97:2000;3579-3584.
12. Matus A. Microtubule-associated proteins: their potential role in dermining neuronal morphology. Annu. Rev. Neurosci. 11:1988;29-44.
13. Tucker R.P. The roles of microtubule-associated proteins in brain morphogenesis: a review. Brain Res. Rev. 15:1990;101-120.
14. Fellous A., Francon J. Microtubule assembly in vitro. Purification of assembly-promoting factors. Eur. J. Biochem. 78:1977;167-174.
15. Itoh T.J., Hisanaga S., Hosoi T., Kshimoto T., Hotani H. Phosphorylation states of microtubule-associated protein 2 (MAP2) determine the regulatory role of MAP2 in microtubule dynamics. Biochemistry. 36:1997;12574-12582.
16. Horwitz S.B. Taxol (paclitaxel): mechanisms of action. Ann. Oncol. 5 Suppl. 6:1994;S3-6.
17. El Etr M., Cordier J., Glowinski J., Premont J. A neuroglial cooperativity is required for the potentration by 2-chloroadenosine of the muscarinic-sensitive phospholipase C in the striatum. J. Neurosci. 9:1989;1473-1480.
18. Compagnone N.A., Mellon S.H. Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development. Proc. Natl. Acad. Sci. USA. 95:1998;46786-46830.
19. Kliewer S.A., Moore J.T., Wade L., Staudinger J.L., Watson M.A., Jones S.A., McKee D.D., Oliver B.B., Willson T.M., Zetterström R.H., Perlmann T., Lehmann J.M. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell. 92:1998;73-82.
20. Lee Y.C., Park C.S., Komatsu K., Kwack J., Strott C.A. Adrenocortical pregnenolone binding activity resides with estrogen sulfotransferase. Endocrinology. 136:1995;361-364.
21. Hamel E., Lin C.M., Flynn E., D'Amato R.J. Interactions of 2-methoxyestradiol, an endogenous mammalian metabolite, with unpolymerized tubulin and with tubulin polymers. Biochemistry. 35:1996;1304-1310.
22. Chauhan N., Siegel G. Age-dependent organotypic expression of microtubule-associated proteins (MAP1, MAP2, and MAP5) in rat brain. Neurochem. Res. 22:1997;713-719.
23. Mandelkow E.M., Mandelkow E. Tau in Alzheimer's disease. Trends Cell Biol. 8:1998;425-427.