Pharmacology of cizolirtine: A new analgesic agent

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 22, Issue 4, 2000, Pages 211-221

  Alvarez, I ^a   Andreu, F ^a   Buxens, J ^a   Colombo, M ^a   Dordal, A ^a   Fort, M ^a   Gutierrez B ^a   Farre A J ^a  

^a Laboratorios Dr Esteve SA   (Spain)

Author keywords

Nonopioid analgesic

Indexed keywords

ACETIC ACID; ACETYLSALICYLIC ACID; ALPHA ADRENERGIC RECEPTOR; AMITRIPTYLINE; ANALGESIC AGENT; CAPSAICIN; CIZOLIRTINE; CODEINE; DESIPRAMINE; DEXAMETHASONE ACETATE; DEXTROPROPOXYPHENE; DICLOFENAC; FORMALDEHYDE; GUM ARABIC; IBUPROFEN; IDAZOXAN; INDOMETACIN; MORPHINE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NALOXONE; OPIATE RECEPTOR; PARACETAMOL; PHENYLQUINONE; SUBSTANCE P; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ANTIPYRETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; MALE; MOUSE; NONHUMAN; PROSTAGLANDIN SYNTHESIS; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN SECRETION; RAT; TAIL FLICK TEST; ULCEROGENESIS;

EID: 0033938992     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2000.22.4.584453     Document Type: Article

References (47)

1. Pert, C.B., Snyder, S.H. Opiate receptor: Demonstration in nervous tissue. Science 1973, 179: 1011-4
2. Reisine, T., Pasternak, G. Opioid analgesics and antagonists. In: The Pharmacological Basis of Therapeutics, Ninth edition. Hardman, J.G., Limbird, L.E. McGraw-Hill: New York 1995, 521-55.
3. Hamberg, M. Inhibition of prostaglandin synthesis in man. Biochem Biophys Res Comm 1972, 49: 720-6
4. Flower, R.J., Moncada, S., Vane, J.R. Drug therapy of inflammation. In: The Pharmacological Basis of Therapeutics, Eighth edition. Gilman, A.G., Goodman, L.S., Rall, T.W. (Eds.). McGraw-Hill: New York 1990, 638-41.
5. Collin, E., Frechilla, D., Pohl, M., Bourgoin, S., Mauborgne, A., Hamon, M., Cesselin, F. Differential effects of the novel analgesic S12813-4, on the spinal release of substance P-and calcitonin gene-released peptide-like materials in the rat. Naun Schmied 1994, 349: 387-93.
6. 2 agonists and antagonists in rats. J Pharm Exp Ther 1992, 261: 764-72.
7. Sullivan, A.F., Dashwood, M.R., Dickenson, A.H. Alpha-2 Adrenoceptor modulation of nociception in rat spinal cord: location, effects and interactions with morphine. Eur J Pharmacol 1987, 138: 169-77.
8. Kuraishi, Y., Hirota, N., Sato, Y., Kanebo, S., Satoh, M., Takagi, H. Noradrenergic inhibition of the release of substance P from the primary afferents in the rabbit spinal cord dorsal horn. Brain Res 1985, 325: 177-82
9. Hokfelt, T., Kellert, J.O., Nilsson, G., Pernow, B. Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons. Brain Res 1975, 100: 235-52.
10. Hokfelt, T., Elde, R., Johansson, O., Luft, R., Nilsson, G., Arimura, A. Immunohistochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurons in the rat. Neuroscience 1976, 1: 131-36.
11. +-evoked release of serotonin and norepinephrine in vivo from rat and cat spinal cord. Brain Res 1980, 192: 133-46.
12. Szelenyi, I., Nickel, B., Borbe, H.O., Brune, K. Mode of antinociceptive action of flupirtine in the rat. Br J Pharmacol 1989, 97: 835-42.
13. Zimmermann, M. Ethical guidelines for investigation of experimental pain in conscious animals. Pain 1983, 16: 109-10.
14. Koster, R., Anderson, M., DeBeer, E.J. Acetic acid for analgesic screening. Fed Proc 1959, 18: 412.
15. Siegmund, E., Cadmus, R., Lu, G. A method for evaluating both non-narcotic and narcotic analgesics. Proc Soc Exp Biol Med 1957, 95: 729.
16. Niemegeers, C.J.E., Van Bruggen, J.A.A., Janssen, P.A.J. Suprofen, a potent antagonist of acetic acid-induced writhing in rats. Arzneim Forsch 1975, 25: 1505-9.
17. Bianchi, C., Franceschini, J. Experimental observations on Haffner's method for testing analgesic drugs. Br J Pharmacol 1954, 9: 280-4.
18. Niemegeers, C.J.E., Lenaerts, F.M., Artois, K.S.K., Janssen, P.A.J. Interaction of drugs with apomorphine, tryptamine and norepinephrine. A new in vivo approach: The ATN test in rats. Arch Int Pharmacodyn Ther 1977, 227: 238-53.
19. D'amour, F.E., Smith, D.L. A method for determining loss of pain sensation. J Pharmacol Exp Ther 1941, 72: 74-9.
20. Ohkubo, T., Tibet, M., Takahashi, H., Inoki, R. Roles of substance P and somatostatin on transmission of nociceptive information induced by formalin in spinal cord. J Pharmacol Exp Ther 1990, 252: 1261-8.
21. Sakurada, T., Katsumata, K., Manome, Y. et al. Antinociceptive effects in the formalin and capsaicin tests after intrathecal administration of substance P analogues in mice. Eur J Pharmacol 1993, 242: 47-52.
22. Hargreaves, K., Dubner, R., Flores, C., Joris, J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988, 32: 77-88.
23. Tofanetti, O., Casciarri, Y., Cipolla, P.V., Cazzulani, P., Omini, C. Effect of nimesulide on cyclo-oxygenase activity in rat gastric mucosa and inflammatory exudate. Med Sci Res 1989, 17: 745-6.
24. Melarange, R., Rashbrook, L.C. Effects of indomethacin, salicylic acid or BW755c on 6-keto-PGF1alpha production from rat gastric tissue ex vivo and in vitro. Br J Pharmacol 1983, 70: 353P.
25. Winter, C.H.A., Risley, E.A., Nuss, G.W. Carrageenin-induced oedema in the hind paw of the rat as an assay for antiinflammatory drugs. Proc Soc Exp Biol Med 1962, 111: 544-7.
26. Rainsford, K. A synergistic interaction between aspirin and other non-steroid anti-inflammatory drugs and stress which produces severe gastric mucosal damage in rats and pigs. Agents Actions 1975, 5: 553-8.
27. Littell, R.C., Freund, R.J., Spector, P.C. SAS System for linear models. Third edition. SAS Institute Inc.: Cary, NC, 1991.
28. Masferrer, J.L., Zweifel, B.S., Manning, P.T,, Hauser, S.D., Leahy, K.M., Smith, W.G., Isakson, P.C., Seibert, K. Selective inhibition of inducible cyclooxygenase-2 in vivo is antiinflammatory and non ulcerogenic. Proc Natl Acad Sci USA 1994, 91: 3228-32.
29. Vane, J.R. Inhibition of prostaglandin synthesis as a mechanism of action for the aspirin-like drugs. Nature 1971, 231: 232-5.
30. Kantner, R.M., Goldstein, B.D., Kirby, M.L. Regulatory mechanisms for substance P in the dorsal horn during a nociceptive stimulus: Axoplasmic transport, versus electrical activity. Brain Res 1986, 385: 282-90.
31. Ono, M., Satoh, T. Pharmacological studies on lappaconitine: Antinociception and inhibition of the spinal action of substance P and somatostatin. Jpn J Pharmacol 1991, 55: 523-30.
32. Du, J., He, L. Alterations of spinal cord dorsal horn substance P following electroacupuncture analgesia: a study of the formalin test with immunohistochemistry and densitometry. Acupunct Electrother Res 1992, 17: 1-6.
33. Gairin, J.E., Gout, R., Meunier, J.C., Cross, J. [D-Pro10 dynorphin(1-11) is a kappa selective opioid analgesic in mice. J. Pharmacol. Exp. Ther 1988, 245: 995-1001.
34. Bouaziz, H., Tong, C., Yoon, Y., Hood, D.D., Eisenach, J.C. Intravenous opioids stimulate norepinephrine and acetylcholine release in spinal cord dorsal horn. Systematic studies in sheep and an observation in a human. Anesthesiology 1996, 84: 143-54.
35. Xu, Z., Tong, C., Pan, H.L., Cerda, S.E., Eisenach, J.C. Intravenous morphine increases release of nitric oxide from spinal cord by an alpha-adrenergic and cholinergic mechanism. J Neurophysiol 1997, 78: 2072-8.
36. Song, H.K., Pan, H.L., Eisenach, J.C. Spinal nitric oxide mediates antinociception from intravenous morphine. Anesthesiology 1998, 89: 215-21.
37. Thomas, D.A., Anton, F., Kenshalo, D.R. Jr., Williams, G.M., Dubner, R. Noradrenergic and opioid systems interact to alter the detection of noxious thermal stimuli and facial scratching in monkeys. Pain. 1993, 55: 63-70.
38. Tseng, L.L., Tang, R. Differential actions of the blockade of spinal opioid adrenergic and serotonergic receptors on the tail-flick inhibition induced by morphine microinjected into dorsal raphe and central gray in rats. Neuroscience 1989, 33: 93-100.
39. Taiwo, Y.O., Fabian, A., Pazoles, C.J., Fields, H.L. Potentiation of morphine antinociception by monoamine reuptake inhibitors in the rat spinal cord. Pain 1985, 21: 329-37.
40. Suh, H.H., Fujimoto, J.M., Tseng, L.L.F. Differential mechanisms mediating beta-endorphin and morphine-induced analgesia in mice. Eur J Pharmacol 1989, 168: 67-70.
41. Hylden, J.L., Thomas, D.A., Iadarola, M.J., Nahin, R.L., Dubner, R. Spinal opioid analgesic effects are enhanced in a model of unilateral inflammation/hyperalgesia; possible involvement of noradrenergic mechanisms. Eur J Pharmacol 1991, 194: 135-43.
42. Rogers, D.T., Iwamoto, E.T. Multiple spinal mediators in parenteral nicotine-induced antinociception. J Pharmacol Exp Ther 1993, 267: 341-9.
43. Henry, J.L. Substance P and inflammatory pain: Potential of substance P antagonists and analgesics. Inflammatory Disease Therapy. Birkhäuser Verlag: Basel 1993, 75-87.
44. Miampamba, M., Chery-Croze, S., Detolle-Sarbach, S., Guez, D., Chayvialle, J.A. Antinociceptive effects of oral clonidine and S12813-4 in acute colon inflammation in rats. Eur J Pharmacol 1996, 308: 251-9.
45. Kuraishi, Y. Neuropeptide-mediated transmission of nociceptive information and its regulation. Novel mechanisms of analgesics. Yakugaku zasshi 1990, 110: 711-26.
46. Ballet, S., Mauborgne, A., Bourgoin, S., Poliénor, H., Farré, A., Cesselin, F., Hamon, M. Effects of the novel analgesic, cizolirtine, on the spinal release of substance P and CGRP in vitro and in vivo studies, submitted.
47. Weihe, E. Neurochemical anatomy of the mammalian spinal cord: Functional implications. Ann Anat 1992, 174: 89-118.