Acyloxymethyl as a drug protecting group. Part 7: Tertiary sulfonamidomethyl ester prodrugs of benzylpenicillin: Chemical hydrolysis and anti-bacterial activity

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 7, 2000, Pages 1629-1636

  Iley, Jim ^a   Barroso, Helena ^b   Moreira, Rui ^b   Lopes, Francisca ^b   Calheiros, Teresa ^b  

^a OPEN UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF LISBON   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOIC ACID; BETA LACTAM; CLOFIBRIC ACID; ESTER; PENICILLIN G; PRODRUG; VALPROIC ACID;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG STABILITY; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; METHODOLOGY; NONHUMAN; PH;

ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; DRUG STABILITY; ESTERS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; KINETICS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PENICILLIN G; PENICILLINS; PRODRUGS; SULFONAMIDES; THERMODYNAMICS;

BACTERIA (MICROORGANISMS);

EID: 0033936572     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00099-7     Document Type: Article

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