Effects of 12 months rec-GH therapy on bone and collagen turnover and bone mineral density in GH deficient children with thalassaemia major

Journal of Endocrinological Investigation

Volumn 23, Issue 6, 2000, Pages 356-361

  Sartorio, Alessandro ^a   Conte, G ^a   Conti, A ^a   Masala, A ^b   Alagna, S ^b   Rovasio, P ^b   Faglia, G ^c  

^a ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^b UNIVERSITY OF SASSARI   (Italy)

^c FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

Bone density; Bone turnover; Collagen turnover; GH; GH deficiency; Thalassaemia

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; RECOMBINANT GROWTH HORMONE; SOMATOMEDIN;

ADOLESCENT; ARTICLE; BODY HEIGHT; BONE DENSITY; BONE METABOLISM; BONE TURNOVER; CHILD; CLINICAL ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; GROWTH HORMONE DEFICIENCY; HUMAN; MALE; OSTEOLYSIS; THALASSEMIA MAJOR;

EID: 0033935826     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03343738     Document Type: Article

References (28)

1. Orvieto R., Leichter I., Rachmilewitz A., Margulies J.Y. Bone density, mineral content, and cortical index in patients with thalassaemia major and the correlation to their bone fractures, blood transfusions, and treatment with desferrioxamine. Calcif. Tissue Int. 1992, 50: 397-399.
2. Lala R., Chiabotto P., Di Stefano M., Isaia G.C., Garofalo F., Piga A. Bone density and metabolism in thalassemia. J. Pediatr. Endocrinol. Metab. 1998, 11: 785-790.
3. Clegg J.B., Weatherall D.J. The Thalassaemia Syndrome, ed. 3. Blackwell Scientific, Oxford, UK, 1985, p. 157.
4. Bisbocci D., Livorno P., Modina P., Gambino M., Damiano P., Cantoni R., Villata E., Chiandussi L. Osteodystrophy in thalassaemia major. Ann. Ital. Med. Int. 1993, 8: 224-226.
5. Filosa A., Di Maio S., Vocca S., Saviano A., Esposito G., Pagano L. Longitudinal monitoring of bone mineral density in thalassaemic patients. Genetic structure and osteoporosis. Acta Paediatr. 1997, 86: 342-346.
6. Costin G., Kogut M.D., Hyman C.B., Ortega J.A. Endocrine abnormalities in thalassaemia major. Am. J. Dis. Child. 1979, 133: 497-502.
7. Borgna-Pignatti C., De Stefano P., Zonta L. Growth and sexual maturation in thalassaemia major. J. Pediatr. 1985, 106: 150-155.
8. El Hazmi M.A.F., Warsy A.S., AL Fawaz I. Iron-endocrine pattern in patients with β-thalassaemia J. Trop. Pediatr. 1994, 40: 219-224.
9. De Simone M., Di Bartolomeo P., Olioso P., Di Girolamo G., Palumbo M., Farello G., Aconito P., Papalinetti G., Bavaro P., Criscione S. Growth after recombinant human growth hormone (rhGH) treatment in transplanted thalassaemic patients. Bone Marrow Transplant 1997, 20: 567-573.
10. Roth C., Pekrun A., Bartz M., Jarry H., Eber S., Lakomek M., Schröter W. Short stature and failure of pubertal development in thalassaemia major: evidence for hypothalamic neurosecretory dysfunction of growth hormone secretion and defective pituitary gonadotropin secretion. Eur. J. Paediatr. 1997, 156: 777-783.
11. Low L.C.K., Poster-Vinay M.C., Kwan E.Y.W., Cheung P.T. Serum growth hormone (GH) binding protein, IGF-I, and IGFBP-3 in patients with β-thalassaemia major and the effect of GH treatment. Clin. Endocrinol. (Oxf.) 1998, 48: 641-646.
12. Cavallo L., Gurrado R., Zecchino C., Manolo F., De Sanctis V., Cistemino M., Caruso-Nicoletti M., Galati M. Short-term therapy with recombinant growth hormone in polytranfused thalassaemia major patients with growth deficiency. J. Pediatr. Endocrinol. Metab. 1998, 11: 845-849.
13. Theodoridis C., Ladis V., Papatheodorou A., Berdousi H., Palamidou F., Evagelopoulou C., Athanassaki K., Konstantoura O., Kattamis C. Growth and management of short stature in thalassaemia major. J. Pediatr. Endocrinol. Metab. 1998, 11: 844-853.
14. Soliman AT., El Banna N., Fattah M.A., El Zalabani M.M., Ansari B.M. Bone mineral density in prepubertal children with beta-thalassemia: correlation with growth and hormonal data. Metabolism 1998, 47: 541-548.
15. Shore R.M., Chesney R.W., Mazess R.B., Rose P.G., Bargman G.J. Bone mineral status in growth hormone deficiency. J. Pediatr. 1980, 96: 393-396.
16. Johansen J.S., Giwercman A., Hartwell D., Nielsen C.T., Price P.A., Christiansen C., Skakkebaek N.E. Serum bone-Gla protein as a marker of bone growth in children and adolescents: correlation with age, height, serum insulin-like growth factor I, and serum testosterone. J. Clin. Endocrinol. Metab. 1988, 67: 273-278.
17. Sartorio A., Conti A., Guzzaloni G., Faglia G. Serum osteocalcin levels in patients with GH deficiency before and during GH treatment. Acta Pediatr. Scand. 1991, 80: 100-102.
18. Sartorio A., Conti A., Monzani M. New markers of bone and collagen turnover in children and adults with growth hormone deficiency. Postgrad. Med. J. 1993, 69: 846-850.
19. Kaufman J.M., Taelman P., Vermeulen A., Vandeweghe M. Bone mineral status in growth hormone-deficient males with isolated and multiple pituitary deficiencies of childhood onset. J. Clin. Endocrinol. Metab. 1992, 74: 118-123.
20. Balducci R., Toscano V., Pasquino A.M., Mangiantini A., Municchi G., Armenise P., Terracina S., Prossomariti G., Boscherini B. Bone turnover and bone mineral density in young adult patients with panhypopituitarism before and after long-term growth hormone therapy. Eur. J. Endocrinol. 1995, 132: 42-46.
21. Sartorio A., Ortolani S., Conti A., Cherubini R., Galbiati E., Faglia G. Effects of recombinant growth hormone (GH) treatment on bone mineral density and body composition in adults with childhood onset growth hormone deficiency. J. Endocrinol. Invest. 1996, 19: 524-529.
22. Ohlsson C., Bengtsson B., Isaksson O.G.P., Andreassen T.T., Slootweg M.C. Growth hormone and bone. Endocr. Rev. 1998, 19: 55-79.
23. Baum H.B.A., Biller B.M.K., Finkelstein J.S., Cannistraro K.B., Oppenheim D.S., Schoenfeld D.A., Michel T.H., Wittink H., Klibanski A. Effect of physiologic growth hormone therapy on bone density and body composition in patients with adult-onset growth hormone deficiency. A randomized, placebo-controlled trial. Ann. Intern. Med. 1996, 125: 883-890.
24. Johannsson G., Rosen T., Bosaeus I., Sjostrom L., Bengtsson B.A. Two years of growth hormone (GH) treatment increases bone mineral content and density in hypopituitary patients with adult-onset GH deficiency. J. Clin. Endocrinol. Metab. 1996, 81: 2865-2873.
25. Sartorio A., Arosio M., Conti A., Ferrero S., Porretti S., and Faglia G. Long-term monitoring of rec-GH treatment by serial determination of serum aminoterminal propeptide of type III procollagen in children and adults with GH deficiency. J. Endocrinol. Invest. 1999, 22: 169-175.
26. Sartorio A., Conti A., Ferrero S., Saraifoger S., Resnik M., Baroncelli G.I. Effects of 12-months rec-GH treatment on bone and collagen turnover in children with constitutional growth delay. J. Pediatr. Endocrinol. Metab. 1999, 12: 833-838.
27. Holmes S.J., Whitehouse R.W., Swindell R., Economou G., Adams J.E., Shalet S.M. Effects of growth hormone replacement on bone mass in adults with adult onset growth hormone deficiency. Clin. Endocrinol. (Oxf.) 1995, 42: 627-633.
28. Hansen T.B., Brixen K., Vahl N., Jorgensen J.O., Christiansen J.S., Mosekilde L., Hagen C. Effects of 12 months of growth hormone (GH) treatment on calciotropic hormones, calcium homeostasis, and bone metabolism in adults with acquired GH deficiency: a double-blind, randomized, placebo-controlled study. J. Clin. Endocrinol. Metab. 1996, 81: 3352-3359.