Lead interaction with human protamine (HP2) as a mechanism of male reproductive toxicity

Chemical Research in Toxicology

Volumn 13, Issue 7, 2000, Pages 594-600

  Quintanilla Vega, Betzabet ^a,b,c   Hoover, Dennis J ^b   Bal, Wojciech ^d,e   Silbergeld, E Ellen ^b   Waalkes, Michael P ^a   Anderson, Larry D ^b  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c DEPARTAMENTO DE FÍSICA   (Mexico)

^d UNIVERSITY OF WROC AW   (Poland)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; LEAD; PROTAMINE; THIOL DERIVATIVE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CHROMATIN CONDENSATION; CHROMATIN STRUCTURE; CONFORMATIONAL TRANSITION; DNA BINDING; DOSE RESPONSE; INFERTILITY; INTOXICATION; LEAD POISONING; PROTEIN DNA INTERACTION; REPRODUCTIVE TOXICITY; SPERM; SPERMATOGENESIS;

ANIMALS; CIRCULAR DICHROISM; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; GENITALIA, MALE; HUMANS; LEAD; MALE; PROTAMINES; PROTEIN BINDING; SPECTROPHOTOMETRY;

EID: 0033931126     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx000017v     Document Type: Article

References (54)

1. Winder, C. (1993) Lead reproduction and development. Neurotoxicology 14, 303-318.
2. Assennato, G., and Paci, C. (1987) Sperm count suppression without endocrine dysfunction in lead-exposed men. Arch. Environ. Health 42, 124-127.
3. McGregor, A. J., and Mason, H. J. (1990) Chronic occupational lead exposure and testicular endocrine function. Human Exp. Toxicol. 9, 371-376.
4. Gustafson, A., Hedner, P., Schutz, A., and Skorfving, S. (1989) Occupational lead exposure and pituitary function. Int. Arch. Occup. Environ. Health 61, 277-281.
5. Ng, T. P., Goh, H., Ng, Y. L., Ong, H. Y., Ong, C. N., Chia, K. S., Chia, S. E., and Jeyaratnam, J. (1991) Male endocrine functions in workers with moderate exposure to lead. Br. J. Ind. Med. 48, 485-491.
6. Johansson, L., and Pellicciari, C. E. (1988) Lead-induced changes in the stabilization of the mouse sperm chromatin. Toxicology 51, 11-24.
7. Wildt, K., Eliasson, R., and Berlin, M. (1983) Effects of occupational exposure to lead on sperm and semen. In Reproductive and Developmental Toxicity of Metals (Clarkson, T. W., Nordberg, G. F., and Sager, P. R., Eds.) pp 279-300, Plenum, New York.
8. Foster, W. G., McMahon, A., and Rice, D. C. (1996) Sperm chromatin structure is altered in cynomolgus monkeys with environmentally relevant blood lead levels. Toxicol. Ind. Health 12, 723-735.
9. Balhorn, R. (1990) Mammalian protamines: Structure and molecular interactions. In Molecular Biology of Chromosome Function (Adolph, K. W., Ed.) pp 366-395, Springer, New York.
10. McKay, D. J., Renaux, B. S., and Dixon, G. H. (1986) Human sperm protamines: Amino acid sequences of two forms of protamine P2. Eur. J. Biochem. 156, 5-8.
11. Bianchi, F., Rousseaux-Prevost, R., Sautiere, P., and Rousseaux, J. (1992) P2 protamines from human sperm are zinc-finger proteins with one Cys2/His2 motif. Biochem. Biophys. Res. Commun. 182, 540-547.
12. Gatewood, J. M., Schroth, G. P., Schmid, C. W., and Bradbury, E. M. (1990) Zinc-induced secondary structure transitions in human sperm protamines. J. Biol. Chem. 265, 20667-20672.
13. Balhorn, R., Reed, S., and Tanphaichitr, N. (1988) Aberrant protamine1/protamine2 ratios in sperm of infertile human males. Experientia 44, 52-55.
14. Blanchard, Y., Lescoat, D., and Le Lannou, D. (1990) Anomalous distribution of nuclear basic proteins in round-headed human spermatozoa. Andrologia 22, 549-555.
15. de Yebra, L., Ballescá, J. L., Vanrell, J. A., Bassas, L., and Oliva, R. (1993) Complete selective absence of protamine P2 in humans. J. Biol. Chem. 268, 10553-10557.
16. (16l de Yebra, L., Ballescá, J. L., Vanrell, J. A., Corzett, M., Balhorn, R., and Oliva, R. (1998) Detection of P2 precursors in the sperm cells of infertile patients who have reduced protamine P2 levels. Fertil. Steril. 69, 755-759.
17. Belokopytova, I. A., Kostyleva, E. I., Tomilin, A. N., and Vorob'ev, V. I. (1993) Human male infertility may be due to a decrease of the protamine P2 content in sperm chromatin. Mol. Reprod. Dev. 34, 53-57.
18. Calvin, H. I., and Bedford, J. M. (1971) Formation of disulphide bonds in the nucleus and accessory structures of mammalian spermatozoa during maturation in the epididymis. J. Reprod. Fertil. 13, 65-75.
19. Bjorndhal, L., and Kvist, U. (1990) Influence of seminal vesicular fluid on the zinc content of human sperm chromatin. Int. J. Androl. 13, 232.
20. Bertini, I., Briganti, F., and Scozzafava, A. (1995) Zinc proteins. In Handbook of Metal-Ligand Interactions in Biological Fluids (Berthon, G., Ed.) pp 175-191. Marcel Dekker, New York.
21. Sunderman, F. W., Jr., and Barber, A. M. (1988) Finger-loops, oncogenes and metals. Ann. Clin. Lab. Sci. 18, 267-288.
22. Goering, P. L. (1993) Lead-protein intractions as a basis for lead toxicity. Neurotoxicology 14, 45-60.
23. Panyim, S., and Chalkley, R. (1969) High-resolution acrylamide gel electrophoresis of histones. Arch. Biochem. Biohpys. 130, 337-346.
24. Bianchi, F., Rousseaux-Prevost, R., Bailly, C., and Rousseaux, J. (1994) Interaction of human P1 and P2 protamines with DNA. Biochem. Biophys. Res. Cummun. 201, 1197-1204.
25. Mehra, R. K., Kodati, R., and Ahdullah, R. (1995) Chain length-dependent Pb(II)-coordination in phytochelatins. Biochem. Biophys. Res. Commun. 215, 730-736.
26. Bal, W., Jezowska-Bojczuk, M., and Kasprzak, K. S. (1997) Binding of nickel(II) and copper(II) to the N-terminal sequence of human protamine HP2. Chem. Res. Toxicol. 10, 906-914.
27. Jezowska-Bojczuk, M., Brasun, J., Lesniak, W., Mlynarz, P., Kozlowski, H., and Bal, W. (1999) Paper presented at the 5th International Symposium on Applied Bioinorganic Chemistry, Corfu, Greece.
28. Fischer, B. E., Haring, U. K., Tribolet, R., and Sigel, H. (1979) Metal ion/buffer interactions. Stability of binary and ternary complexes containing 2-amino-2-(hydroxymethyl)-1,3-propanediol (Tris) and adenosine 5′-triphosphate (ATP). Eur. J. Biochem. 94, 523-530.
29. Vallee, B. L., and Ulmer, D. D. (1972) Chemistry of cadmium, mercury, and lead. Annu. Rev. Biochem. 41, 91-125.
30. Waalkes, M. P., Harvey, M. J., and Klaassen, C. D. (1984) Relative in vitro affinity of hepatic metallothionein for metals. Toxicol. Lett. 20, 33-39.
31. Wetmur, J. G. (1994) Influence of the common human δ-aminole-vulinate dehydratase polymorphism on lead body burden. Environ. Health Perspect. 102 (Suppl. 3), 215-219.
32. 2+ in calmodulin. Arch. Toxicol. 54, 61-70.
33. Quintanilla-Vega, B., Smith, D. R., Kahng, M. W., Hernández, J. M., Albores, A., and Fowler, B. A. (1995) Lead-binding proteins in brain tissue of environmentally lead-exposed humans. Chem.-Biol. Interact. 98, 193-209.
34. Borden, K. L. B., Martin, S. R., O'Reilly, N. J., Lally, J. M., Reddy, B. A., Etkin, L. D., and Freemont, P. S. (1993) Characterisation of a novel cysteine/histidine-rich metal binding domain from Xenopus nuclear factor XNF7. FEBS Lett. 335, 255-260.
35. Krizek, B. A., Merkle, D. L., and Berg, J. M. (1993) Ligand variation and metal ion binding specificity in zinc finger peptides. Inorg. Chem. 32, 937-940.
36. Roehm, P. C., and Berg, J. M. (1997) Sequential metal binding by the RING finger domain of BRCA1. Biochemistry 36, 10240-10245.
37. 2: an example of metal ion-promoted conformational organization which results in exceptionally high complex stability. J. Inorg. Biochem. 52, 79-87.
38. Woody, R. W. (1992) Circular dichroism and conformation of unordered polypeptides. Adv. Biophys. Chem. 2, 37-39.
39. Hanas, J. S., Rodgers, J. S., Bantle, J. A., and Cheng, Y.-G. (1999) Lead inhibition of DNA-binding mechanism of Cys2-His2 zinc finger proteins. Mol. Pharmacol. 56, 982-988.
40. Zawia, N. H., Sharan, R., Brydie, M., Oyama, T., and Crumpton, T. (1998) Sp1 as a target site for metal-induced perturbations of transcriptional regulation of developmental brain gene expression. Dev. Brain Res. 107, 291-298.
41. Balhorn, R. (1982) A model for the structure of chromatin in mammalian sperm. J. Cell Biol. 93, 298-305.
42. Phe. Implications for lead toxicity and self-splicing RNA. Nature 303, 543-546.
43. Kvist, U. (1980) Importance of spermatozoal zinc as temporary inhibitor of sperm nuclear chromatin decondensation ability in man. Acta Physiol. Scand. 109, 79-84.
44. Perreault, S. D., Naish, S. J., and Zirkin, B. R. (1987) The timing of hamster sperm nuclear decondensation and male pronucleus formation is related to sperm nuclear disulfide bond content. Biol. Reprod. 36, 239-244.
45. El-Zohairy, E. A., Youssef, A. F., Abul-Nasr, S. M., Fahmy, I. M., Salem, D., Kahl, A. K., and Madkour, M. K. (1996) Reproductive hazards of lead exposure among urban egyptian men. Reprod. Toxicol. 2, 145-151.
46. Robins, T. G. (1997) Semen quality and fertility of men employed in a south African lead acid battery plant. Am. J. Ind. Health 32, 369-376.
47. Johansson, L., and Wide, M. (1986) Long-term exposure of the male mouse to lead: effects on fertility. Environ. Res. 41, 481-487.
48. Fisher-Fischbein, J., Michaeli, M., Maslansky, B., Fischbein, A., Langsam, J., and Bartoov, B. (1999) In vitro investigation of spermatotoxic effects of lead and copper and the involvement of zinc. Paper presented at the International Conference on Lead Exposure, Reproductive Toxicity and Carcinogenicity, Gargnano, Italy.
49. Batra, N., Nehru, B., and Bansal, M. P. (1998) The effect of zinc supplementation on the effects of lead on the rat testis. Reprod. Toxicol. 12, 535-540.
50. Sega, G. A. (1991) Adducts in sperm protamine and DNA vs mutation frequency. Prog. Clin. Biol. Res. 372, 521-530.
51. Aravindan, G. R., Bjordahl, J., Jost, L. K., and Evenson, D. P. (1997) Susceptibility of human sperm to in situ DNA denaturation is strongly correlated with DNA strand breaks identified by single-cell electrophoresis. Exp. Cell Res. 236, 231-237.
52. Gorczyca, W., Traganos, F., Jesionowska, H., and Darzynkiewicz, Z. (1993) Presence of DNA strand breaks and increased sensitivity of DNA in situ to denaturation in abnormal human sperm cells: analogy to apoptosis of somatic cells. Exp. Cell Res. 207, 202-205.
53. Johnson, F. M. (1998) The genetic effects of environmental lead. Mutat. Res. 410, 123-140.
54. Gandley, R. E., Anderson, L. D., and Silbergeld, E. K. (1999) Lead: Male-mediated effects on reproduction and development in the rat. Environ. Res. 80, 355-363.