메뉴 건너뛰기




Volumn 10, Issue 4, 2000, Pages 417-420

Engineering therapeutic proteins

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; MONOCLONAL ANTIBODY; PROTEIN; TRASTUZUMAB;

EID: 0033928843     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(00)00108-1     Document Type: Review
Times cited : (17)

References (28)
  • 1
    • 85031596952 scopus 로고    scopus 로고
    • Annual report: The World's Biotechnology Companies
    • This report concisely reviews information on biotechnology companies and their products in the clinic. It tabulates the composition, indication, developer and launch date of the drugs, as well as sales totals for 1998 (contact for back issues)
    • Annual report: The World's Biotechnology Companies. Pharma Business, 1999:30-52. This report concisely reviews information on biotechnology companies and their products in the clinic. It tabulates the composition, indication, developer and launch date of the drugs, as well as sales totals for 1998 (contact http://www.pharmabusiness.com for back issues).
    • (1999) Pharma Business , pp. 30-52
  • 2
    • 85031582570 scopus 로고    scopus 로고
    • New Medicines in Development: Biotechnology on World Wide Web URL: This is the web site of PhRMA, an organisation representing approximately 100 American Pharmaceutical Companies. "Medicines in Development 2000" is a review that lists products in development by category of product, indication and clinical trial status
    • New Medicines in Development: Biotechnology on World Wide Web URL: http://www.phrma.org/charts/b_c00.html . This is the web site of PhRMA, an organisation representing approximately 100 American Pharmaceutical Companies. "Medicines in Development 2000" is a review that lists products in development by category of product, indication and clinical trial status.
  • 3
    • 85031579356 scopus 로고    scopus 로고
    • Genentech Products on World Wide Web URL
    • Genentech Products on World Wide Web URL http://www.genentech.com/products/ .
  • 5
    • 85031583434 scopus 로고    scopus 로고
    • Centocor (Products) on World Wide Web URL
    • Centocor (Products) on World Wide Web URL http://www.centocor.com .
  • 6
    • 0034716486 scopus 로고    scopus 로고
    • Therapeutic monoclonal antibodies
    • Breedveld F.C. Therapeutic monoclonal antibodies. Lancet. 355:2000;735-740.
    • (2000) Lancet , vol.355 , pp. 735-740
    • Breedveld, F.C.1
  • 7
    • 85031585318 scopus 로고    scopus 로고
    • Novartis "What We Do" on World Wide Web URL
    • Novartis "What We Do" on World Wide Web URL http://www.pharma.us.novartis.com/what/ .
  • 8
    • 0022558297 scopus 로고
    • Replacing the complementarity-determining regions in a human antibody with those from a mouse
    • Jones P.T., Dear P.H., Foote J., Neuberger M.S., Winter G. Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature. 321:1986;522-525.
    • (1986) Nature , vol.321 , pp. 522-525
    • Jones, P.T.1    Dear, P.H.2    Foote, J.3    Neuberger, M.S.4    Winter, G.5
  • 9
    • 85031590063 scopus 로고    scopus 로고
    • Protein Design Labs Products in Clinical Development on World Wide Web URL
    • Protein Design Labs Products in Clinical Development on World Wide Web URL http://www.pdl.com/PDLProducts/ClinTable/clintable.htm .
  • 10
    • 85031589316 scopus 로고    scopus 로고
    • MedImmune Inc. Products on the Market on World Wide Web URL
    • MedImmune Inc. Products on the Market on World Wide Web URL http://www.medimmune.com/medimmune/products/pom.html .
  • 11
    • 0000898623 scopus 로고    scopus 로고
    • The pharmacological basis of anti-IgE therapy
    • Chang T.W. The pharmacological basis of anti-IgE therapy. Nat Biotechnol. 18:2000;157-162.
    • (2000) Nat Biotechnol , vol.18 , pp. 157-162
    • Chang, T.W.1
  • 12
    • 0026559783 scopus 로고
    • Antibody framework residues affecting the conformation of the hypervariable loops
    • Foote J., Winter G. Antibody framework residues affecting the conformation of the hypervariable loops. J Mol Biol. 224:1992;487-499.
    • (1992) J Mol Biol , vol.224 , pp. 487-499
    • Foote, J.1    Winter, G.2
  • 14
    • 0025226085 scopus 로고
    • Phage antibodies: Filamentous phage displaying antibody variable domains
    • McCafferty J., Griffiths A.D., Winter G., Chiswell D.J. Phage antibodies: filamentous phage displaying antibody variable domains. Nature. 348:1990;552-554.
    • (1990) Nature , vol.348 , pp. 552-554
    • McCafferty, J.1    Griffiths, A.D.2    Winter, G.3    Chiswell, D.J.4
  • 15
    • 85031594938 scopus 로고    scopus 로고
    • Cambridge Antibody Technology Group Therapeutic Products on World Wide Web URL
    • Cambridge Antibody Technology Group Therapeutic Products on World Wide Web URL http://www.cambridgeantibody.com/therapeutics/index.html .
  • 16
    • 0027136111 scopus 로고
    • Affinity maturation of human growth hormone by monovalent phage display
    • Lowman H.B., Wells J.A. Affinity maturation of human growth hormone by monovalent phage display. J Mol Biol. 234:1993;564-578.
    • (1993) J Mol Biol , vol.234 , pp. 564-578
    • Lowman, H.B.1    Wells, J.A.2
  • 17
    • 0032705008 scopus 로고    scopus 로고
    • Preliminary results of early clinical trials with the fully human anti-TNFα antibody D2E7
    • D2E7 is the first antibody derived from phage display to show benefit in the clinic. It is currently in phase III clinical trials for the treatment of rheumatoid arthritis. This article reviews earlier results, in which up to 80% of patients showed clinically significant benefits following intravenous or subcutaneous administration.
    • Kempeni J. Preliminary results of early clinical trials with the fully human anti-TNFα antibody D2E7. Ann Rheum Dis. 58:1999;170-172. D2E7 is the first antibody derived from phage display to show benefit in the clinic. It is currently in phase III clinical trials for the treatment of rheumatoid arthritis. This article reviews earlier results, in which up to 80% of patients showed clinically significant benefits following intravenous or subcutaneous administration.
    • (1999) Ann Rheum Dis , vol.58 , pp. 170-172
    • Kempeni, J.1
  • 18
    • 0031466808 scopus 로고    scopus 로고
    • Immunotherapeutic potential of bispecific antibodies
    • van de Winkel J.G.J., Bast B., de Gast G.C. Immunotherapeutic potential of bispecific antibodies. Immunol Today. 18:1997;562-564.
    • (1997) Immunol Today , vol.18 , pp. 562-564
    • Van De Winkel, J.G.J.1    Bast, B.2    De Gast, G.C.3
  • 19
    • 85031583305 scopus 로고    scopus 로고
    • Medarex Platform Technologies on World Wide Web URL
    • Medarex Platform Technologies on World Wide Web URL http://www.medarex.com/researchF.html .
  • 20
    • 85031582201 scopus 로고    scopus 로고
    • Ligand Pharmaceuticals (Products) on World Wide Web URL
    • Ligand Pharmaceuticals (Products) on World Wide Web URL http://www.ligand.com .
  • 21
    • 0030669930 scopus 로고    scopus 로고
    • Recombinant human tumour necrosis factor receptor p75 Fc fusion protein (TNFR:Fc) in rheumatoid arthritis
    • Murray K.M., Dahl S.L. Recombinant human tumour necrosis factor receptor p75 Fc fusion protein (TNFR:Fc) in rheumatoid arthritis. Ann Pharmacother. 31:1997;1335-1338.
    • (1997) Ann Pharmacother , vol.31 , pp. 1335-1338
    • Murray, K.M.1    Dahl, S.L.2
  • 22
    • 0033526641 scopus 로고    scopus 로고
    • Comparison of subcutaneous and intravenous interleukin-2 in asymptomatic HIV-1 infection: A randomised controlled trial. ANRS 048 study group
    • Levy Y., Capitant C., Houhou S., Carriere I., Viard J.P., Goujard C., Gastaut J.A., Oksenhendler E., Boumsell L., Gomard E.et al. Comparison of subcutaneous and intravenous interleukin-2 in asymptomatic HIV-1 infection: a randomised controlled trial. ANRS 048 study group. Lancet. 353:1999;1923-1929.
    • (1999) Lancet , vol.353 , pp. 1923-1929
    • Levy, Y.1    Capitant, C.2    Houhou, S.3    Carriere, I.4    Viard, J.P.5    Goujard, C.6    Gastaut, J.A.7    Oksenhendler, E.8    Boumsell, L.9    Gomard, E.10
  • 23
    • 85031594006 scopus 로고    scopus 로고
    • Rapilysin-EPAR on World Wide Web URL
    • Rapilysin-EPAR on World Wide Web URL http://www2.eudra.org/humandocs/humans/EPAR/Rapilysin/Rapilysin.htm .
  • 24
    • 0029644942 scopus 로고
    • Role of C-terminal B-chain residues in insulin assembly: The structure of hexameric LysB28ProB29-human insulin
    • Ciszak E., Beals J.M., Frank B.H., Baker J.C., Carter N.D., Smith G.D. Role of C-terminal B-chain residues in insulin assembly: the structure of hexameric LysB28ProB29-human insulin. Structure. 3:1995;615-622.
    • (1995) Structure , vol.3 , pp. 615-622
    • Ciszak, E.1    Beals, J.M.2    Frank, B.H.3    Baker, J.C.4    Carter, N.D.5    Smith, G.D.6
  • 25
    • 85031594793 scopus 로고    scopus 로고
    • Chiron Products on World Wide Web URL
    • Chiron Products on World Wide Web URL http://www.chiron.com/products/index.html .
  • 26
    • 0004065053 scopus 로고    scopus 로고
    • London: Association of British Pharmaceutical Industry URL
    • Hall, M. An A to Z of British Medicines Research. London: Association of British Pharmaceutical Industry; 1998. [URL: http://www.abpi.org.uk/publications/patient_info.htm ].
    • (1998) An a to Z of British Medicines Research
    • Hall, M.1
  • 27
    • 85031591125 scopus 로고    scopus 로고
    • Protein Structure Initiative on World Wide Web URL
    • Protein Structure Initiative on World Wide Web URL: http://www.structuralgenomics.org/ .
  • 28
    • 17444406988 scopus 로고    scopus 로고
    • Semi-rational design of a potent, artificial agonist of fibroblast growth factor receptors
    • This article illustrates the feasibility of using selection technology combined with knowledge of receptor signalling to create a peptide agonist of fibroblast growth factor. As well as a requirement for dimerisation, there was a requirement for heparin binding in both natural and mimetic agonists. The marriage of selection/screening technology with biological or structural knowledge is likely to be a feature of future engineered protein therapeutics.
    • Ballinger M.D., Shyamala V., Forrest L.D., Deuter-Reinhard M., Doyle L.V., Wang J.X., Panganiban-Lustan L., Stratton J.R., Apell G., Winter J.A.et al. Semi-rational design of a potent, artificial agonist of fibroblast growth factor receptors. Nat Biotechnol. 17:1999;1199-2104. This article illustrates the feasibility of using selection technology combined with knowledge of receptor signalling to create a peptide agonist of fibroblast growth factor. As well as a requirement for dimerisation, there was a requirement for heparin binding in both natural and mimetic agonists. The marriage of selection/screening technology with biological or structural knowledge is likely to be a feature of future engineered protein therapeutics.
    • (1999) Nat Biotechnol , vol.17 , pp. 1199-2104
    • Ballinger, M.D.1    Shyamala, V.2    Forrest, L.D.3    Deuter-Reinhard, M.4    Doyle, L.V.5    Wang, J.X.6    Panganiban-Lustan, L.7    Stratton, J.R.8    Apell, G.9    Winter, J.A.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.