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1
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85031596952
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Annual report: The World's Biotechnology Companies
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This report concisely reviews information on biotechnology companies and their products in the clinic. It tabulates the composition, indication, developer and launch date of the drugs, as well as sales totals for 1998 (contact for back issues)
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Annual report: The World's Biotechnology Companies. Pharma Business, 1999:30-52. This report concisely reviews information on biotechnology companies and their products in the clinic. It tabulates the composition, indication, developer and launch date of the drugs, as well as sales totals for 1998 (contact http://www.pharmabusiness.com for back issues).
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(1999)
Pharma Business
, pp. 30-52
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2
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85031582570
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New Medicines in Development: Biotechnology on World Wide Web URL: This is the web site of PhRMA, an organisation representing approximately 100 American Pharmaceutical Companies. "Medicines in Development 2000" is a review that lists products in development by category of product, indication and clinical trial status
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New Medicines in Development: Biotechnology on World Wide Web URL: http://www.phrma.org/charts/b_c00.html . This is the web site of PhRMA, an organisation representing approximately 100 American Pharmaceutical Companies. "Medicines in Development 2000" is a review that lists products in development by category of product, indication and clinical trial status.
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3
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85031579356
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Genentech Products on World Wide Web URL
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Genentech Products on World Wide Web URL http://www.genentech.com/products/ .
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4
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0025647882
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Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum
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Shak S., Capon D.J., Hellmiss R., Marsters S.A., Baker C.L. Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum. Proc Natl Acad Sci USA. 87:1990;9188-9192.
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Proc Natl Acad Sci USA
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Shak, S.1
Capon, D.J.2
Hellmiss, R.3
Marsters, S.A.4
Baker, C.L.5
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5
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85031583434
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Centocor (Products) on World Wide Web URL
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Centocor (Products) on World Wide Web URL http://www.centocor.com .
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6
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0034716486
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Therapeutic monoclonal antibodies
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Breedveld F.C. Therapeutic monoclonal antibodies. Lancet. 355:2000;735-740.
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Lancet
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, pp. 735-740
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Breedveld, F.C.1
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7
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85031585318
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Novartis "What We Do" on World Wide Web URL
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Novartis "What We Do" on World Wide Web URL http://www.pharma.us.novartis.com/what/ .
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8
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0022558297
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Replacing the complementarity-determining regions in a human antibody with those from a mouse
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Jones P.T., Dear P.H., Foote J., Neuberger M.S., Winter G. Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature. 321:1986;522-525.
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Nature
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Jones, P.T.1
Dear, P.H.2
Foote, J.3
Neuberger, M.S.4
Winter, G.5
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9
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85031590063
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Protein Design Labs Products in Clinical Development on World Wide Web URL
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Protein Design Labs Products in Clinical Development on World Wide Web URL http://www.pdl.com/PDLProducts/ClinTable/clintable.htm .
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10
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85031589316
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MedImmune Inc. Products on the Market on World Wide Web URL
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MedImmune Inc. Products on the Market on World Wide Web URL http://www.medimmune.com/medimmune/products/pom.html .
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11
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0000898623
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The pharmacological basis of anti-IgE therapy
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Chang T.W. The pharmacological basis of anti-IgE therapy. Nat Biotechnol. 18:2000;157-162.
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Nat Biotechnol
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Chang, T.W.1
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12
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0026559783
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Antibody framework residues affecting the conformation of the hypervariable loops
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Foote J., Winter G. Antibody framework residues affecting the conformation of the hypervariable loops. J Mol Biol. 224:1992;487-499.
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(1992)
J Mol Biol
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Foote, J.1
Winter, G.2
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14
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0025226085
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Phage antibodies: Filamentous phage displaying antibody variable domains
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McCafferty J., Griffiths A.D., Winter G., Chiswell D.J. Phage antibodies: filamentous phage displaying antibody variable domains. Nature. 348:1990;552-554.
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(1990)
Nature
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McCafferty, J.1
Griffiths, A.D.2
Winter, G.3
Chiswell, D.J.4
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15
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85031594938
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Cambridge Antibody Technology Group Therapeutic Products on World Wide Web URL
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Cambridge Antibody Technology Group Therapeutic Products on World Wide Web URL http://www.cambridgeantibody.com/therapeutics/index.html .
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16
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0027136111
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Affinity maturation of human growth hormone by monovalent phage display
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Lowman H.B., Wells J.A. Affinity maturation of human growth hormone by monovalent phage display. J Mol Biol. 234:1993;564-578.
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J Mol Biol
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Lowman, H.B.1
Wells, J.A.2
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17
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0032705008
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Preliminary results of early clinical trials with the fully human anti-TNFα antibody D2E7
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D2E7 is the first antibody derived from phage display to show benefit in the clinic. It is currently in phase III clinical trials for the treatment of rheumatoid arthritis. This article reviews earlier results, in which up to 80% of patients showed clinically significant benefits following intravenous or subcutaneous administration.
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Kempeni J. Preliminary results of early clinical trials with the fully human anti-TNFα antibody D2E7. Ann Rheum Dis. 58:1999;170-172. D2E7 is the first antibody derived from phage display to show benefit in the clinic. It is currently in phase III clinical trials for the treatment of rheumatoid arthritis. This article reviews earlier results, in which up to 80% of patients showed clinically significant benefits following intravenous or subcutaneous administration.
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(1999)
Ann Rheum Dis
, vol.58
, pp. 170-172
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Kempeni, J.1
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19
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85031583305
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Medarex Platform Technologies on World Wide Web URL
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Medarex Platform Technologies on World Wide Web URL http://www.medarex.com/researchF.html .
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20
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85031582201
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Ligand Pharmaceuticals (Products) on World Wide Web URL
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Ligand Pharmaceuticals (Products) on World Wide Web URL http://www.ligand.com .
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21
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0030669930
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Recombinant human tumour necrosis factor receptor p75 Fc fusion protein (TNFR:Fc) in rheumatoid arthritis
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Murray K.M., Dahl S.L. Recombinant human tumour necrosis factor receptor p75 Fc fusion protein (TNFR:Fc) in rheumatoid arthritis. Ann Pharmacother. 31:1997;1335-1338.
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Ann Pharmacother
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Murray, K.M.1
Dahl, S.L.2
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22
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0033526641
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Comparison of subcutaneous and intravenous interleukin-2 in asymptomatic HIV-1 infection: A randomised controlled trial. ANRS 048 study group
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Levy Y., Capitant C., Houhou S., Carriere I., Viard J.P., Goujard C., Gastaut J.A., Oksenhendler E., Boumsell L., Gomard E.et al. Comparison of subcutaneous and intravenous interleukin-2 in asymptomatic HIV-1 infection: a randomised controlled trial. ANRS 048 study group. Lancet. 353:1999;1923-1929.
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(1999)
Lancet
, vol.353
, pp. 1923-1929
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Levy, Y.1
Capitant, C.2
Houhou, S.3
Carriere, I.4
Viard, J.P.5
Goujard, C.6
Gastaut, J.A.7
Oksenhendler, E.8
Boumsell, L.9
Gomard, E.10
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23
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85031594006
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Rapilysin-EPAR on World Wide Web URL
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Rapilysin-EPAR on World Wide Web URL http://www2.eudra.org/humandocs/humans/EPAR/Rapilysin/Rapilysin.htm .
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24
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0029644942
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Role of C-terminal B-chain residues in insulin assembly: The structure of hexameric LysB28ProB29-human insulin
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Ciszak E., Beals J.M., Frank B.H., Baker J.C., Carter N.D., Smith G.D. Role of C-terminal B-chain residues in insulin assembly: the structure of hexameric LysB28ProB29-human insulin. Structure. 3:1995;615-622.
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Structure
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Ciszak, E.1
Beals, J.M.2
Frank, B.H.3
Baker, J.C.4
Carter, N.D.5
Smith, G.D.6
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25
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85031594793
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Chiron Products on World Wide Web URL
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Chiron Products on World Wide Web URL http://www.chiron.com/products/index.html .
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26
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0004065053
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London: Association of British Pharmaceutical Industry URL
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Hall, M. An A to Z of British Medicines Research. London: Association of British Pharmaceutical Industry; 1998. [URL: http://www.abpi.org.uk/publications/patient_info.htm ].
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An a to Z of British Medicines Research
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Hall, M.1
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27
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85031591125
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Protein Structure Initiative on World Wide Web URL
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Protein Structure Initiative on World Wide Web URL: http://www.structuralgenomics.org/ .
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28
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17444406988
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Semi-rational design of a potent, artificial agonist of fibroblast growth factor receptors
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This article illustrates the feasibility of using selection technology combined with knowledge of receptor signalling to create a peptide agonist of fibroblast growth factor. As well as a requirement for dimerisation, there was a requirement for heparin binding in both natural and mimetic agonists. The marriage of selection/screening technology with biological or structural knowledge is likely to be a feature of future engineered protein therapeutics.
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Ballinger M.D., Shyamala V., Forrest L.D., Deuter-Reinhard M., Doyle L.V., Wang J.X., Panganiban-Lustan L., Stratton J.R., Apell G., Winter J.A.et al. Semi-rational design of a potent, artificial agonist of fibroblast growth factor receptors. Nat Biotechnol. 17:1999;1199-2104. This article illustrates the feasibility of using selection technology combined with knowledge of receptor signalling to create a peptide agonist of fibroblast growth factor. As well as a requirement for dimerisation, there was a requirement for heparin binding in both natural and mimetic agonists. The marriage of selection/screening technology with biological or structural knowledge is likely to be a feature of future engineered protein therapeutics.
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(1999)
Nat Biotechnol
, vol.17
, pp. 1199-2104
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Ballinger, M.D.1
Shyamala, V.2
Forrest, L.D.3
Deuter-Reinhard, M.4
Doyle, L.V.5
Wang, J.X.6
Panganiban-Lustan, L.7
Stratton, J.R.8
Apell, G.9
Winter, J.A.10
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