The endometrium as a novel target for leptin: Differences in fertility and subfertility

Molecular Human Reproduction

Volumn 6, Issue 7, 2000, Pages 595-601

  Alfer, Joachim ^a   Müller Schöttle, Frank ^a   Classen Linke, Irmgard ^a   Von Rango, Ulrike ^a   Happel, Lars ^b   Beier Hellwig, Karin ^a   Rath, Werner ^a   Beier, Henning M ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b Institute of Reproductive Medicine   (Germany)

Author keywords

Endometrium; Functional leptin receptor; Immunohistochemistry; RT PCR; Subfertility

Indexed keywords

LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; STEROID RECEPTOR;

ARTICLE; ENDOMETRIUM; FEMALE; FEMALE FERTILITY; FOLLICULAR PHASE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LUTEAL CELL; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; METABOLISM; OBESITY; PARACRINE SIGNALING; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; REPRODUCTION; SUBFERTILITY;

EID: 0033925294     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/6.7.595     Document Type: Article

References (30)

1. Alfer, J., Happel, L., Beier-Hellwig, K. et al. (1998) Molecular analysis challenges a new definition of the 'endometrial factor' in infertility diagnosis. J. Reprod. Fertil. (Abstr. Ser.), 22, 22.
2. Alfer, J., Happel, L. Beier-Hellwig, K. et al. (1999a) Significance of marker molecules in the assessment of endometrial quality in infertility patients. Hum. Reprod., 14 (Abstr. Book 1), 371-372.
3. Alfer, J., I. Classen-Linke, W. Rath et al. (1999b) Functional leptin receptor located in human endometrium. Hum. Reprod., 14 (Abstr. Book 1), 266-267.
4. Baskin, D.G., Schwartz, M.W., Seeley, R.J. et al. (1999) Leptin receptor long-form splice-variant protein expression in neuron cell bodies of the brain and co-localization with neuropeptide Y mRNA in the arcuate nucleus. J. Histochem. Cytochem., 47, 353-362.
5. Baumann, H., Morella, K.K., White, D.W. et al. (1996) The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc. Natl Acad. Sci. USA, 93, 8374-8378.
6. Beier-Hellwig, K., Sterzik, K., Bonn, B. et al. (1989) Contribution to the physiology and pathology of endometrial receptivity: the determination of protein patterns in human uterine secretions. Hum. Reprod., 4 (Suppl), 115-120.
7. Bjorbaek, Ch., Uotani, S., da Silva, B. et al. (1997) Divergent signaling capacities of the long and short isoforms of the leptin receptor. J. Biol. Chem., 272, 32686-32695.
8. Bodner, J., Ebenbichler, C.F., Wolf, H.J. et al. (1999) Leptin receptor in human term placenta: in situ hybridization and immunohistochemical localization. Placenta, 20, 677-682.
9. Bouloumié, A., Drexler, H.C.A., Lafontan, M. et al. (1998) Leptin, the product of ob gene, promotes angiogenesis. Circ. Res., 83, 1059-1066.
10. Chehab, F.F., Lim, M.E. and Lu, R. (1996) Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genet., 12, 318-320.
11. Chien, E.K., Hara, M., Rouard, M. et al. (1997) Increase in serum leptin and uterine leptin receptor messenger RNA levels during pregnancy in rats. Biochem. Biophys Res. Commun., 237, 476-480.
12. Cioffi, J.A., Shafer, A.W., Zupancic, T.J. et al. (1996) Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction. Nature Med., 2, 585-589.
13. Cioffi, J.A., Van Blerkom, J., Antczak, M. et al. (1997) The expression of leptin and its receptor in pre-ovulatory human follicles. Mol. Hum. Reprod., 3, 467-472.
14. Classen-Linke, I., Alfer, J., Krusche, C., Chwalisz, K. et al. (2000) Progestins, progesterone receptor modulators and antagonists change VEGF-release of endometrial cells in culture. Steroids, in press.
15. Cumin, F., Baum, H.P. and Levens, N. (1997) Mechanism of leptin removal from the circulation by the kidney. J. Endocrinol., 155, 577-585.
16. Dieterich, K.D. and Lehnert, H. (1998) Expression of leptin receptor mRNA and the long form splice variant in human anterior pituitary and pituitary adenoma. Exp. Clin. Endocrinol. Diabetes, 106, 522-525.
17. Glasow, A., Haidan, A., Hilbers, U. et al. (1998) Expression of Ob receptor in normal human adrenals: differential regulation of adrenocortical and adrenomedullary function by leptin. J. Clin. Endocrinol. Metab., 83, 4459-4466.
18. Lee, G.H., Proenca, R., Montez, J.M. et al. (1996) Abnormal splicing of the leptin receptor in diabetic mice. Nature, 379, 632-635.
19. Licino, J., Mantzoros, Ch., Negrão, A.B. et al. (1997) Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nature Med., 3, 575-579.
20. Masuzaki, H., Ogawa, Y., Sagawa, N. et al. (1997) Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nature Med., 3, 1029-1033.
21. Mounzih, K., Lu, R. and Chehab, F.F. (1997) Leptin treatment rescues the sterility of genetically obese ob/ob males, Endocrinology, 138, 1190-1193.
22. Noyes, R.W., Hertig, A.T. and Rock, J. (1950) Dating the endometrial biopsy. Fertil. Steril., 1, 3-25.
23. Pinkney, J.H., Goodrick, S.J., Katz, J. et al. (1998) Leptin and the pituitary-thyroid axis: a comparative study in lean, obese, hypothyroid and hyperthyroid subjects. Clin. Endocrinol., 49, 583-588.
24. Pralong, F.P., Roduit, R., Waeber, G. et al. (1998) Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland. Endocrinology, 139, 4264-4268.
25. Riad-Gabriel, M.G., Jinagouda, S.D., Sharma, A. et al. (1998) Changes in plasma leptin during the menstrual cycle. Eur. J. Endocrinol., 139, 528-531.
26. Sierra-Honigmann, M.R., Nath, A.K., Murakami, C. et al. (1998) Biological action of leptin as an angiogenic factor. Science, 281, 1683-1686.
27. Spicer, L.J. and Francisco, C.C. (1998) Adipose obese gene product, leptin, inhibits bovine ovarian thecal cell steroidogenesis. Biol. Reprod., 58, 207-212
28. Tartaglia, L.A., Dembski, M., Weng, X. et al. (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell, 83, 1263-1271.
29. Zachow, R.J. and Magoffin, D.A. (1997) Direct intraovarian effects of leptin: impairment of the synergistic action of insulin-like growth factor-I on follicle-stimulating hormone-dependent estradiol-17 beta production by rat ovarian granulosa cells. Endocrinology, 138, 847-850.
30. Zhang, Y., Proenca, R., Maffei, M. et al. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature, 372, 425-432.