Attenuation of the bidirectional effects of chlordiazepoxide and FG 7142 on conditioned response suppression and associated cardiovascular reactivity by loss of cortical cholinergic inputs

Psychopharmacology

Volumn 150, Issue 2, 2000, Pages 141-149

  Stowell, J R ^a   Berntson, G G ^a   Sarter, M ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Acetylcholine; Anxiety; Basal forebrain; Chlordiazepoxide; FG 7142; Heart rate; Rat

Indexed keywords

ACETYLCHOLINESTERASE; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; CHLORDIAZEPOXIDE; IMMUNOGLOBULIN G; N METHYL BETA CARBOLINE 3 CARBOXAMIDE; SAPORIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN CORTEX; CARDIOVASCULAR RESPONSE; CHOLINERGIC NERVE CELL; CONDITIONED REFLEX; CONTROLLED STUDY; FOREBRAIN; HEART RATE; HISTOPATHOLOGY; INSTRUMENTAL CONDITIONING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TELEMETRY;

ANIMALS; ANTI-ANXIETY AGENTS; CARBOLINES; CHLORDIAZEPOXIDE; CHOLINERGIC FIBERS; CONDITIONING, OPERANT; GABA ANTAGONISTS; HEART RATE; MALE; MOTOR ACTIVITY; PROSENCEPHALON; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0033919759     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130000443     Document Type: Article

References (54)

1. Angrini M, Leslie JC, Shephard RA (1998) Effects of propranolol, buspirone, pCPA, reserpine, and chlordiazepoxide on open-field behavior. Pharmacol Biochem Behav 59:387-397
2. Berntson GG, Quigley KS, Jang JF, Boysen ST (1990) An approach to artifact identification: application to heart period data. Psychophysiology 27:586-598
3. Berntson GG, Cacioppo JT, Quigley KS (1995) The metrics of cardiac chronotropism: biometric perspectives. Psychophysiology 32:162-171
4. Berntson GG, Hart S, Ruland S, Sarter M (1996a) A central cholinergic link in the cardiovascular effects of the benzodiazepine receptor partial inverse agonist FG 7142. Behav Brain Res 74:91-103
5. Berntson GG, Sarter M, Ruland S, Hart S, Ronis V (1996b) Benzodiazepine receptor agonists and inverse agonists yield concordant rather than opposing effects on startle responses. J Psychopharmacol 10:309-312
6. Berntson GG, Sarter M, Cacioppo JT (1998) Anxiety and cardiovascular reactivity: the basal forebrain cholinergic link. Behav Brain Res 94:225-248
7. Black AH, de Toledo L (1972) The relationship among classically conditioned responses: heart rate and skeletal behavior. In: Black AH, Prokasy WF (eds) Classical conditioning II: Current theory and research. Appleton-Century-Crofts, New York, pp 290-311
8. Bucci DJ, Holland PC, Gallagher M (1998) Removal of cholinergic input to rat posterior parietal cortex disrupts incremental processing of conditioned stimuli. J Neurosci 18:8038-8046
9. Cole BJ, Hillmann M (1994) Effects of benzodiazepine receptor ligands on the performance of an operant delayed matching to position task in rats: opposite effects of FG 7142 and lorazepam. Psychopharmacology 115:350-357
10. Cole BJ, Hillmann M, Seidelmann D, Klewer M, Jones GH (1995) Effects of benzodiazepine receptor partial inverse agonists in the elevated plus maze test of anxiety in the rat. Psychopharmacology 121:118-126
11. Davis M (1990) Animal models of anxiety based on classical conditioning: the conditioned emotional response (CER) and the fear-potentiated startle effect. Pharmacol Ther 47:147-165
12. Davis M (1992) The role of amygdala in fear and anxiety. Ann Rev Neurosci 15:353-375
13. Eysenck MW (1991) Cognitive factors in clinical anxiety: potential relevance to therapy. In: Briley M, File SE (eds) New concepts in anxiety. CRC Press, Boca Raton, pp 418-433
14. Fadel J, Moore H, Sarter M, Bruno JP (1996) Trans-synaptic stimulation of cortical acetylcholine release after partial 192 IgG-saporin-induced loss of cortical cholinergic afferents. J Neurosci 16:6592-6600
15. File SE, Baldwin HA (1987) Effects of beta-carbolines in animal models of anxiety. Brain Res Bull 19:293-299
16. Fitzgerald RD, Stainbrook GL, Francisco D (1985) Classically conditioned bradycardia and skeletal-motor activity in restrained rats. Physiol Psychol 13:211-216
17. Frysztak RJ, Neafsey EJ (1994) The effect of medial frontal cortex lesions on cardiovascular conditioned emotional responses in the rat. Brain Res 643:181-193
18. Gibbs CM, Prescott LB, Powell DA (1992) A comparison of multiple-unit activity in the medial prefrontal and agranular insular cortices during Pavlovian heart rate conditioning in rabbits. Exp Brain Res 89:599-610
19. Ginn SR, Powell DA (1992) Nucleus basalis lesions attenuate acquisition, but not retention, of Pavlovian heart rate conditioning and have no effect on eyeblink conditioning. Exp Brain Res 89:501-510
20. Gonzalez LE, Andrews N, File SE (1996) 5-HT1A and benzodiazepine receptors in the basolateral amygdala modulate anxiety in the social interaction test, but not in the elevated plus-maze. Brain Res 732:145-153
21. Hart S, Sarter M, Berntson GG (1998) Cardiovascular and somatic startle and defense: concordant and discordant actions of benzodiazepine receptor agonists and inverse agonists. Behav Brain Res 90:175-186
22. Hart S, Sarter M, Bernston GG (1999) Cholinergic inputs to the medial prefrontal cortex mediate potentiation of the cardiovascular defensive response by the anxiogenic benzodiazepine receptor partial inverse agonist FG 7142. Neuroscience 94:1029-1038
23. Heckers S, Ohtake T, Wiley RG, Lappi DA, Geula C, Mesulam MM (1994) Complete and selective cholinergic denervation of rat neocortex and hippocampus but not amygdala by an immunotoxin against the p75 NGF receptor. J Neurosci 14:1271-1289
24. Holley LA, Wiley RG, Lappi DA, Sarter M (1994) Cortical cholinergic deafferentation following the intracortical infusion of 192 IgG-saporin: a quantitative histochemical study. Brain Res 663:277-286
25. Holley LA, Turchi J, Apple C, Sarter M (1995) Dissociation between the attentional effects of infusions of a benzodiazepine receptor agonist and an inverse agonist into the basal forebrain. Psychopharmacology 120:99-108
26. Horger B, Elsworth JD, Rother RH (1995) Selective increase in dopamine utilization in the shell subdivision of the nucleus accumbens by the benzodiazepine receptor inverse agonist FG 7142. J Neurochem 65:770-774
27. Howell DC (1992) Statistical methods for psychology, 3rd edn. Duxbury Press, Belmont, CA
28. Hunt PS, Hess MF, Cambell BA (1994) Autonomic mediation of unconditioned and conditioned heart rate responses in the 16-day-old rat. Psychobiology 22:209-218
29. Hunt PS, Richardson R, Hess MF, Campbell BA (1997) Emergence of conditioned cardiac responses to an olfactory CS paired with an acoustic startle UCS during development: form and autonomic origins. Dev Psychobiol 30:151-163
30. Iwata J, LeDoux JE (1988) Dissociation of associative and nonassociative concomitants of classical fear conditioning in the freely behaving rat. Behav Neurosci 102:66-76
31. Jensen LH, Peterson EN, Braestrup C (1983) Audiogenic seizures in DBA/2 mice discriminate sensitively between low efficacy benzodiazepine receptor agonists and inverse agonists. Life Sci 33:393-399
32. Kurtz MM, Campbell BA (1994) Paradoxical autonomic responses to aversive stimuli in the developing rat. Behav Neurosci 108:962-971
33. LeDoux JE (1993) Emotional memory systems in the brain. Behav Brain Res 58:69-79
34. LeDoux JE (1995) Emotion: clues from the brain. Ann Rev Psychol 46:209-235
35. Lysakowski A, Wainer BH, Bruce G, Hersh LB (1989) An atlas of the regional and laminar distribution of choline acetyltransferase immunoreactivity in rat cerebral cortex. Neuroscience 28:291-336
36. McGaughy J, Sarter M (1995) Behavioral vigilance in rats: task validation and effects of age, amphetamine, and benzodiazepine receptor ligands. Psychopharmacology 117:340-357
37. McGaughy J, Kaiser T, Sarter M (1996) Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: selectivity of the behavioral impairment and relation to cortical Ache-positive fiber density. Behav Neurosci 110:247-265
38. Murphy BL, Arnsten AF, Goldman-Rakic PS, Roth RH (1996) Increased dopamine in the prefrontal cortex impairs spatial working memory performance in rats and monkeys. Proc Natl Acad Sci USA 93:1325-1329
39. Nakane H, Shimizu N, Hori T (1994) Stress-induced norepinephrine release in the rat prefrontal cortex measured by microdialysis. Am J Physiol 267:R1559-R1566
40. Obrist PA, Galosy RA, Lawler JE, Gaebelein CJ, Howard JL, Shankds EM (1975) Operant conditioning of heart rate: somatic correlates. Psychophysiology 12:445-455
41. Ohman A (1996) Preferential preattentive processing of threat in anxiety: preparedness and attentional biases. In: Rapee RM (ed) Current controversies in the anxiety disorders. Guilford Press, New York, pp 253-290
42. Phillips RG, LeDoux JE (1992) Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 106:274-285
43. Powell DA, Watson K, Maxwell B (1994) Involvement of subdivisions of the medial prefrontal cortex in learned cardiac adjustments in rabbits. Behav Neurosci 108:294-307
44. Quigley KS, Sarter MF, Hart SL, Berntson GG (1994) Cardiovascular effects of the benzodiazepine receptor partial inverse agonist FG 7142 in rats. Behav Brain Res 62:11-20
45. Sarter M, Bruno JP (1994) Cognitive functions of cortical ACh: lessons from studies on trans-synaptic modulation of activated efflux. Trends Neurosci 17:217-221
46. Sarter M, Bruno JP (1999) Abnormal regulation of corticopetal cholinergic neurons and impaired information processing in neuropsychiatric disorders. Trends Neurosci 22:67-74
47. Sarter M, Dudchenko P (1991) Dissociative effects of ibotenic and quisqualic acid-induced basal forebrain lesions on cortical acetylcholinesterase-positive fiber density and cytochrome oxidase activity. Neuroscience 41:729-738
48. Sarter M, Bruno JP, Turchi J (1999) Basal forebrain afferent projections modulating cortical acetylcholine, attention, and implications for neuropsychiatric disorders. Ann NY Acad Sci 877:368-382
49. Stichel CC, Singer W (1987) Quantitative analysis of the choline acetyltransferase-immunoreactive axonal network in the cat primary visual cortex. J Comp Neurol 258:91-98
50. Sullivan RM, Gratton A (1999) Lateralized effects of medial prefrontal cortex lesions on neuroendocrine and autonomic stress responses in rats. J Neurosci 19:2834-2840
51. Tago H, Kimura H, Maeda T (1986) Visualization of detailed acetycholinesterase fiber and neuron staining in rat brain by a sensitive histochemical procedure. J Histochem Cytochem 34:1431-1438
52. Takeda H, Tsuji M, Matsumiya T (1998) Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and/or anxiolytic state in mice. Eur J Pharmacol 350:21-29
53. Thiebot MH, Dangoumau L, Richard G, Puech AJ (1991) Safety signal withdrawal: a behavioral paradigm sensitive to both "anxiolytic" and "anxiogenic" drugs under identical experimental conditions. Psychopharmacology 103:415-424
54. Turchi J, Sarter M (1997) Cortical acetylcholine and processing capacity: effects of cortical cholinergic deafferentation on cross-modal divided attention in rats. Cogn Brain Res 6:147-158