Metallothionein in mice reduces intestinal zinc loss during acute endotoxin inflammation, but not during starvation or dietary zinc restriction

Journal of Nutrition

Volumn 130, Issue 8, 2000, Pages 1901-1909

  Philcox, Jeffrey C ^a   Sturkenboom, Marieke ^a   Coyle, Peter ^a   Rofe, Allan M ^a  

^a INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

Author keywords

Endotoxin; Metallothionein; Mice; Zinc

Indexed keywords

METALLOTHIONEIN; ZINC;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; BODY MASS; CONTROLLED STUDY; DIET RESTRICTION; FECES; INFLAMMATION; MINERAL BALANCE; MOUSE; NONHUMAN; NUTRITIONAL DEFICIENCY; STARVATION; TISSUE DISTRIBUTION; URINARY EXCRETION; ZINC DEFICIENCY;

EID: 0033916578     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/130.8.1901     Document Type: Article

References (45)

1. Abe, S., Matsumi, M., Tsukioki, M., Mizukawa, S., Takahashi, T., Iijima, Y., Itano, Y. & Kosaka, F. (1987) Metallothionein and zinc metabolism in endotoxin shock rats. Experientia 52: 587-593.
2. Andrews, G. K. & Geiser, J. (1999) Expression on the mouse metallothionein-I and -II genes provides a reproductive advantage during maternal dietary zinc deficiency. J. Nutr. 129: 1643-1648.
3. Beattie, J. H., Wood, A. M., Newman, A. M., Bremner, I., Choo, K.H.A., Michalska, A. E., Duncan, J. S. & Trayhurn, P. (1998) Obesity and hyperleptinemia in metallothionein (-I and -II) null mice. Proc. Natl. Acad. Sci. U.S.A. 95: 358-363.
4. Beattie, J. H., Wood, A. M., Newman, A. M., Bremner, I., Choo, K.H.A., Michalska, A. E., Duncan, J. S. & Trayhurn, P. (1999) Obesity and hyperleptinemia in a colony of metallothionein (-I and -II) null mice. In: Metallothionein IV (Klaassen, C. D., ed.), pp. 505-510, Birkhauser Verlag, Berlin, Germany.
5. Black, B. L., Croom, J., Eisen, E. J., Petra, A. E., Edwards, C. L. & Surwit, R. S. (1998) Differential effects of fat and sucrose on body composition in A/J and C57BL6 mice. Metabolism 47: 1354-1359.
6. Brand, I. A. & Kleineke, J. (1996) Intracellular zinc movement and its effect on the carbohydrate metabolism of isolated rat hepatocytes. J. Biol. Chem. 271: 1941-1949.
7. Cousins, R. J. (1985) Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. Physiol. Rev. 65: 238-309.
8. Coyle, P., Philcox, J. C. & Rofe, A. M. (1993) Corticosterone enhances the zinc and interleukin-6-mediated induction of metallothionein in cultured hepatocytes. J. Nutr. 123: 1464-1470.
9. Coyle, P., Philcox, J. C. & Rofe, A. M. (1995) Hepatic zinc in metallothionein-null mice following zinc challenge: in vivo and in vitro studies. Biochem. J. 309: 25-31.
10. Coyle, P., Philcox, J. C. & Rofe, A. M. (1999) Metallothionein-null mice absorb less Zn from an egg-white diet, but a similar amount from solutions, although with altered intertissue Zn distribution. J. Nutr. 129: 372-379.
11. Cui, L., Takagi, Y., Wasa, M., Iiboshi, Y., Inoue, M., Khan, J., Sando, K., Nezu, R. & Okada, A. (1998) Zinc deficiency enhances interteukin-1-α induced metallothionein-1 expression in rats. J. Nutr. 128: 1092-1098.
12. Dalton, T., Fu, K., Palmiter, R. D. & Andrews, G. K. (1996) Transgenic mice that overexpress metallothionein-1 resist dietary zinc deficiency. J. Nutr. 126: 825-833.
13. De, S. K., McMasters, M. T. & Andrews, G. K. (1990) Endotoxin induction of murine metallothionein gene expression. J. Biol. Chem. 265: 15267-15274.
14. De, S. K., Sandford, T. H. & Wood, G. W. (1992) Detection of interleukin-6, and tumour necrosis factor in the uterus during the second half of pregnancy in the mouse. Endocrinology 131: 14-20.
15. De Lisle, R. C., Sarras, M. P., Jr., Hidalgo, J. & Andrews, G. K. (1996) Metallothionein is a component of exocrine pancreas secretion: implications for zinc homeostasis. Am. J. Physiol. 271: C1103-C1110.
16. Eaton, D. L. & Toal, B. F. (1982) Evaluation of the Cd/hemoglobin assay for the rapid determination of metallothionein in biological tissues. Toxicol. Appl. Pharmacol. 66: 134-142.
17. Flanagan, P. R., Haist, J. & Valberg, L. S. (1983) Zinc absorption, intraluminal zinc and intestinal metallothionein in zinc-deficient and zinc-replete rodents. J. Nutr. 113: 962-972.
18. Gaetke, L. M., McClain, C. J., Talwalkar, R. T. & Shedlofsky, S. I. (1997) Effects of endotoxin on zinc metabolism in human volunteers. Am. J. Physiol. 272: E952-E956.
19. Giugliano, R. & Millward, D. J. (1987) The effects of severe zinc deficiency on protein turnover in muscle and thymus. Br. J. Nutr. 57: 139-155.
20. Hamer, D. H. (1986) Metallothionein. Annu. Rev. Biochem. 55: 913-951.
21. Jeffery, D., Edwards, Y. H., Jackson, M. J., Jeffery, S. & Carter, N. D. (1982) Zinc and carbonic anhydrase III distribution in mammalian muscle. Comp. Biochem. Physiol. 73: 971-975.
22. Kägi, J.H.R. and Kojima Y. (1987) Chemistry and biochemistry of metallothionein. In: Metallothionein II (Kägi J.H.R. and Kojima Y., ed.), pp. 25-62, Birkhäuser. Verlag, Basel, Switzerland.
23. Kelly, E. J., Quaife, C. J., Froelick, G. J. & Palmiter, R. D. (1996) Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice. J. Nutr. 126: 1782-1790.
24. Kennedy, K. J., Rains, T. M. & Shay, N. F. (1998) Zinc deficiency changes preferred macronutrient intake in subpopulations of Sprague-Dawley outbred rats and reduces hepatic pyruvate kinase gene expression. J. Nutr. 128: 43-49.
25. Maret, W., Jacob, C., Vallee, B. L. & Fischer, E. H. (1999) Inhibitory sites in enzymes: zinc removal and reactivation by thionein. Proc. Natl. Acad. Sci. U.S.A. 96: 1936-1940.
26. Michalska, A. & Choo, K.H.A. (1993) Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse. Proc. Natl. Acad. Sci. U.S.A. 90: 8088-8092.
27. O'Leary, M. J., McClain, C. J. & Hegarty, P.V. J. (1979) Effect of zinc deficiency on the weight, cellularity and zinc concentration of different skeletal muscles of the post-weanling rat. Br. J. Nutr. 42: 487-495.
28. Opara, E. C., Petro, A., Tevrizian, A., Feinglos, M. N. & Surwit, R. S. (1996) L-Glutamine supplementation of a high fat diet reduces body weight and attenuates hyperglycemia and hyperinsulinemia in C57BL/6J mice. J. Nutr. 126: 273-279.
29. Pekarek, R. S. & Evans, G. W. (1975) Effect of acute infection and endotoxemia on zinc absorption in the rat. Proc. Soc. Exp. Biol. Med. 150: 755-758.
30. Pekarek, R. S. & Evans, G. W. (1976) Effect of leukocytic endogenous mediator (LEM) on zinc absorption in the rat. Proc. Soc. Exp. Biol. Med. 152: 573-574.
31. Philcox, J. C., Coyle, P., Michalska, A., Choo, C.H.A. & Rofe, A. M. (1995) Endotoxin-induced inflammation does not cause hepatic zinc accumulation in mice lacking metallothionein gene expression. Biochem. J. 308: 543-546.
32. Quaife, C., Hammer, R. E., Mottet, N. K. & Palmiter, R. D. (1986) Glucocorticoid regulation of metallothionein during murine development. Dev. Biol. 118: 549-555.
33. Richards, M. P. & Cousins, R. J. (1975) Mammalian zinc homeostasis: requirements for RNA and metallothionein synthesis. Biochem. Biophys. Res. Commun. 64: 1215-1223.
34. Richards, M. P. &Cousins, R. J. (1976) Metallothionein and its relationship to the metabolism of dietary zinc in rats. J. Nutr. 106: 1591-1599.
35. Robinson, A. M. & Williamson, D. H. (1980) Physiological role of ketone bodies as substrates and signals in mammalian tissues. Physiol. Rev. 60: 143-187.
36. Rofe, A. M., Barry E. F., Shelton T. L., Philcox, J. C. & Coyle, P. (1998) Paracetamol hepatotoxicity in metallothionein-null mice. Toxicology 125: 131-140.
37. Rofe, A. M., Philcox, J. C. & Coyle, P. (1996) Trace metal, acute phase and metabolic response to endotoxin in metallothionein-null mice. Biochem. J. 314: 793-797.
38. Rofe, A. M., Philcox, J. C., Sturkenboom, M. & Coyle, P. (1999a) Zinc homeostasis during pregnancy in metallothionein-null mice on a low zinc diet. In: Metallothionein IV (Klaassen, C. D., ed.), pp. 309-314, Birkhauser Verlag, Berlin, Germany.
39. Rofe, A. M. & Williamson, D. H. (1983) Metabolic effects of vasopressin infusion in the starved rat: reversal of ketonaemia. Biochem. J. 212: 231-239.
40. Rofe, A. M., Winters, N., Hinskens, B., Philcox, J. C. & Coyle, P. (1999b) The role of the pancreas in intestinal secretion in metallothionein-null mice. Pancreas 19: 69-75.
41. Surwit, R. S., Feinglos, M. N., Rodin, J., Sutherland, A., Petro, A. E., Opara, E. C., Kuhn, C. M. & Rebuffe-Scrive, M. (1995) Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. Metabolism 44: 645-651.
42. Tran, C. D., Butler, R. N., Philcox, J. C., Rofe, A. M., Howarth, G. S. & Coyle, P. (1998) Regional distribution of metallothionein and zinc in the mouse gut: comparison with metallothionein-null mice. Biol. Trace Elem. Res. 63: 239-251.
43. Tukey, J. W. (1949) Comparing individual means in the analysis of variance. Biometrics 5: 99-114.
44. Wastney, M. E., Angelus, P. A., Barnes, R. M. & Subramanian, K. N. (1999) Zinc absorption, distribution, excretion, and retention by healthy preterm infants. Pediatr. Res. 45: 191-196.
45. Yunice, A. A., King, R. W., Kraikitpanitch S., Haywood C. C. & Lindeman R. D. (1978) Urinary zinc excretion following infusions of zinc sulfate, cysteine, histidine, or glycine. Am. J. Physiol. 235: F40-F45.