Schizotypal disorder: At the crossroads of genetics and nosology

Acta Psychiatrica Scandinavica

Volumn 94, Issue 5, 1996, Pages 303-310

  Battaglia, M ^a   Torgersen, S ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Genetics; Personality; Schizophrenia; Schizotypal disorder

Indexed keywords

GENETICS; HUMAN; PERSONALITY DISORDER; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SCHIZOIDISM; SCHIZOPHRENIA;

EID: 0029856039     PISSN: 0001690X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0447.1996.tb09865.x     Document Type: Review

References (94)

1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 3rd edn. Washington, DC: American Psychiatric Association, 1980.
2. KRETSCHMER E. Korperbau und charakter. Berlin: Springer Verlag, 1931.
3. ESSEN-MOLLER E, WOHLFAHRT S. Suggestions for the amendment of the official Swedish classification of mental disorders. Acta Psychiatr Scand 1947: 47 (Suppl.): 511.
4. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th edn. Washington, DC: American Psychiatric Association, 1994.
5. GUNDERSON JG, SIEVER LJ. Relatedness of schizotypal to schizophrenic disorders: editors' introduction. Schizophr Bull 1985: 11: 532-537.
6. KENDLER KS. Toward a scientific psychiatric nosology. Strengths and limitations. Arch Gen Psychiatry 1990: 47: 969-973.
7. BATTAGLIA M, BELLODI L. Schizotypal disorder. Hosp Commun Psychiatry 1992: 43: 82-83.
8. TORGERSEN S. Relatedness of schizotypal personality disorder to schizophrenia: genetics. Schizophr Bull 1985: 11: 554-563.
9. SMERALDI E. Genetics and psychopathology for schizophrenic disorders. In: SMERALDI E, BELLODI L, ed. A genetic perspective for schizophrenia and related disorders. Milan: Edi Ermes, 1988: 1-8.
10. FRANCES AJ. Validating schizotypal personality disorder: problems with the schizophrenia connection. Schizophr Bull 1985: 11: 595-597.
11. KETY SS. Schizotypal personality disorder: an operational definition of Bleuler's latent schizophrenia? Schizophr Bull 1985: 11: 590-594.
12. KRAEPELIN E. Psychiatrie: ein Lehrbuch. Leipzig: Barth, 1913.
13. BLEULER E. Dementia praecox oder gruppe der schizophrenien. Leipzig-Wien: Franz Deuticke, 1911.
14. BARETT AM. Heredity relations in schizophrenia. In: Schizophrenia: an investigation of the most recent advances (Association for Research in Nervous and Mental Disease). New York: Paul B Hoeber Inc., 1928: 67-93.
15. KALLMAN FJ. The genetics of schizophrenia. New York: JJ Augustin, 1938.
16. SLATER E. Psychotic and neurotic illnesses in twins. London: Her Majesty's Stationery Office, 1953.
17. KENDLER KS. Diagnostic approaches to schizotypal personality disorder. A historical perspective. Schizophr Bull 1985: 11: 538-553.
18. ZILBOORG G. Ambulatory schizophrenia. Psychiatry 1941: 4: 149-155.
19. HOCH PH, POLATIN P. Pseudoneurotic forms of schizophrenia. Psychiatr Quart 1949: 23: 248-276.
20. RADO S. Dynamics and classification of disordered behavior. Am J Psychiatry 1953: 110: 406-416.
21. SPITZER RL, ENDICOTT J, GIBBON M. Crossing the border into borderline personality and borderline schizophrenia: the development of criteria. Arch Gen Psychiatry 1979: 36: 17-24.
22. EYSENCK HJ, EYSENCK SBG. Psychoticism as a dimension of personality. London: Hodder & Stoughton, 1976.
23. CHAPMAN LJ, CHAPMAN JP. Psychosis proneness. In: ALPERT M, ed. Controversies in schizophrenia. New York: Guilford Press, 1985: 157-174.
24. RAINE A, REYNOLDS C, LENCZ T, SCERBO A, TRIPHON N, KIM D. Cognitive-perceptual, interpersonal and disorganized features of schizotypal personality. Schizophr Bull 1994: 20: 191-201.
25. VOLLEMA MG, VAN DEN BOSCH RJ. The multidimensionality of schizotypy. Schizophr Bull 1995: 21: 19-31.
26. MEEHL PE. Schizotaxia, schizotypy, schizophrenia. Am Psychol 1962: 17: 827-838.
27. MEEHL PE. Schizotaxia revisited. Arch Gen Psychiatry 1989; 46: 935-944.
28. MEEHL PE. Toward an integrated theory of schizotaxia, schizotypy and schizophrenia. J Pers Dis 1990: 4: 1-99
29. LENZENWEGER MF. Explorations in schizotypy and the psychometric high risk paradigm. In: CHAMPMAN LG et al., ed. Progress in experimental personality and psychopathology research. New York: Springer, 1993: 66-116.
30. MOLDIN SO, ERLENMEYER-KIMLING L. Measuring liability to schizophrenia: progress report 1994: editors' introduction. Schizophr Bull 1994: 20: 25-29.
31. NIGG JT, GOLDSMITH HH. Genetics of personality disorders: perspectives from personality and psychopathology research. Psychol Bull 1994: 3: 346-380.
32. LENZENWEGER MF, LORANGER AW. Detection of familial schizophrenia using a psychometric measure of schizotypy. Arch Gen Psychiatry 1989; 46: 902-907.
33. THAKER G, MORAN M, ADAMI H, CASSADY S. Psychosis proneness scales in schizophrenia spectrum personality disorders: familial vs. non-familial samples. Psychiatry Res 1993: 46: 47-57.
34. CLARIDGE G. Single indicator of risk for schizophrenia: probable fact or likely myth? Schizophr Bull 1994: 20: 151-168.
35. MCGLASHAN T. Schizotypal personality disorder: Chestnut Lodge follow-up study. VI. Long-term follow-up perspectives. Arch Gen Psychiatry 1986: 43: 329-334.
36. BATTAGLIA M, ABBRUZZESE M, FERRI S, BELLODI L, SCARONE S, SMERALDI E. An assessment of the Wisconsin Card Sorting Test as an indicator of liability to schizophrenia. Schizophr Res 1994: 14: 39-46.
37. GOTTESMAN II. Schizophrenia genesis: the origins of madness. New York: W.H. Freeman and Co., 1991.
38. CORYELL W, ZIMMERMAN M. The heritability of schizophrenia and schizoaffective disorder: a family study. Arch Gen Psychiatry 1988: 45: 323-327.
39. KENDLER KS. Familial aggregation of schizophrenia and schizophrenia spectrum disorders. Evaluation of conflicting results. Arch Gen Psychiatry 1988: 45: 377-383.
40. TIENARI P. Interaction between genetic vulnerability and family environment: the Finnish adoptive family study of schizophrenia. Acta Psychiatr Scand 1991: 84: 460-465.
41. KENDLER KS, DIEHL SR. The genetics of schizophrenia. A current, genetic epidemiologic perspective. Schizophr Bull 1993: 19: 261-286.
42. KETY SS, ROSENTHAL D, WENDER PH, SCHULSINGER F, JACOBSEN B. The types and prevalence of mental illness in the biological and adoptive families of adopted schizophrenics. J Psychiatr Res 1968: 6: 345-362.
43. KENDLER KS, GRUENBERG AS, KINNEY DK. Independent diagnoses of adoptees and relatives as defined by the DSM-III in the provincial and national samples of the Danish adoption study of schizophrenia. Arch Gen Psychiatry 1994: 51: 456-468.
44. LOWING PA, MIRSKY AF, PEREIRA R. The inheritance of schizophrenia-spectrum disorders: a reanalysis of the Danish adoptee data. Am J Psychiatry 1983: 140: 1167-1172.
45. BARON M, GRUEN R, RAINER JD, KANE J, ASNIS L, LORD S. A family study of schizophrenic and normal control probands: implications for the spectrum concept of schizophrenia. Am J Psychiatry 1985: 142: 447-455.
46. FRANGOS E, ATHANASSENAS G, TSITOURIDES S, KATSANOU N, ALEXANDRAKOU P. Prevalence of DSM-III schizophrenia among the first-degree relatives of schizophrenic probands. Acta Psychiatr Scand 1985: 72: 382-386.
47. CORYELL W, ZIMMERMAN M. Personality disorders in the families of depressed, schizophrenic and never-ill probands. Am J Psychiatry 1989: 146: 496-502.
48. GERSHON ES, DE LISI LE, HAMOVIT J et al. A controlled family study of chronic psychoses. Arch Gen Psychiatry 1988: 45: 328-336.
49. ONSTAD S, SKRE I, EDVARDSEN J, TORGERSEN S, KRINGLEN E. Mental disorders in first-degree relatives of schizophrenics. Acta Psychiatr Scand 1991: 83: 463-467.
50. KENDLER KS, MCGUIRE M, GRUENBERG AM, O'HARE A, SPELLMAN M, WALSH D. The Roscommon family study. I. Methods, diagnosis of probands and risks for schizophrenia in relatives. Arch Gen Psychiatry 1993: 50: 527-540.
51. KETY SS, WENDER PH, JACOBSEN B et al. Mental illness in the biological and adoptive relatives of schizophrenic adoptees. Replication of the Copenhagen study in the rest of Denmark. Arch Gen Psychiatry 1994: 51: 442-455.
52. TORGERSEN S, ONSTAD S, SKRE I, EDVARDSEN J, KRINGLEN E. 'True' schizotypal personality disorder: a study of co-twins and relatives of schizophrenic probands. Am J Psychiatry 1993: 150: 1661-1667.
53. SQUIRES-WHEELER E, SKODOL AE, BASSETT A, ERLENMAYER-KIMLING L. DSM-III-R schizotypal personality traits in offspring of schizophrenic disorder, affective disorder, and normal control parents. J Psychiatr Res 1989: 23: 229-239.
54. SOUIRES-WHEELER E, SKODOL AE, FRIEDMAN D, ERLENMAYER-KIMLING L. The specificity of DSM-III schizotypal personality traits. Psychol Med 1988: 18: 757-765.
55. KRINGLEN E, CRAMER G. Offspring of monozygotic twins discordant for schizophrenia. Arch Gen Psychiatry 1989: 46: 873-877.
56. CLONINGER CR, VON KNORRING AL, SIGVARDSSON S, BOHMAN M. Clinical predictors of familial psychopathology: principles, methods, and findings. In: DUNNER DL. Relatives at risk for mental disorders. New York: Raven Press, 1988: 9-29.
57. BATTAGLIA M, GASPERINI G, SCIUTO G, SCHERILLO P, BELLODI L. Psychiatric disorders in the families of schizotypal subjects. Schizophr Bull 1991: 17: 659-668.
58. SOLOFF P, MILLWARD JW. Psychiatric disorders in the families of borderline patients. Arch Gen Psychiatry 1983: 40: 37-44.
59. TORGERSEN S. Genetic and nosologie aspects of schizotypal and borderline personality disorders: a twin study. Arch Gen Psychiatry 1984: 41 546-554.
60. BARON M, GRUEN R, ASNIS L, LORD S. Familial transmission of schizotypal and borderline personality disorders. Am J Psychiatry 1985: 142: 927-934.
61. SCHULZ PM, SCHULZ SC, GOLDBERG SC, ETTIGI P, RESNICK RJ, FRIEDAL RO. Diagnoses of the relatives of schizotypal outpatients. J Nerv Ment Dis 1986: 174: 457-463.
62. SCHULZ PM, SOLOFF PH, KELLY T, MORGENSTERN M, DIFRANCO R, SCHULZ SC. A family history study of borderline subtypes. J Pers Dis 1989: 3: 217-229.
63. SIEVER LJ, SILVERMAN JM, HORVATH TB et al. Increased morbid risk for schizophrenia-related disorders in relatives of schizotypal personality disordered patients. Arch Gen Psychiatry 1990: 47: 634-640.
64. THAKER G, ADAMI H, MORAN M, LAHTI A, CASSADY S. Psychiatric illness in families of subjects with schizophrenia spectrum personality disorders: high morbidity risks for unspecified functional psychoses and schizophrenia. Am J Psychiatry 1993: 150: 66-71.
65. BATTAGLIA M, BERNARDESCHI L, FRANCHINI L, BELLODI L, SMERALDI E. A family study of schizotypal disorder. Schizophr Bull 1995: 21: 33-45.
66. SLATER E, COWIE VA. The genetics of mental disorders. London: Oxford University Press, 1971: 12-16.
67. BATTAGLIA M, BELLODI L. Familial risks and reproductive fitness in schizophrenia. Schizophr Bull 1996: 22: 191-195.
68. REICH T, CLONINGER CR, GUZE SB. The multifactorial model of disease transmission. Description of the model and its use in psychiatry. Br J Psychiatry 1975: 127: 1-10.
69. CLONINGER CR, REICH T, WETZEL R. Alcoholism and affective disorders: familial association, and genetic models. In: GOODWIN DW, ERICKSON CK, ed. Alcoholism and affective disorders. New York: Spectrum Publications, 1979: 57-85.
70. TORGERSEN S, SKRE I, ONSTAD S, EDVARDSEN J, KRINGLEN E. The psychometric-genetic structure of DSM-III-R personality disorder criteria. J Pers Dis 1993: 7: 196-213.
71. SILVER LJ, KALUS OF, KEEFE RSE. The boundaries of schizophrenia. Psychiatr Clin N Am 1993: 16: 217-244.
72. SIEVER LJ, DAVIS KL. A psychobiological perspective on the personality disorders. Am J Psychiatry 1991: 148: 1647-1658.
73. CORNBLATT BA, ERLENMEYER-KIMLING L. Global attentional deviance as a marker of risk for schizophrenia: specificity and predictive validity. J Abnorm Psychol 1985: 94: 470-486.
74. SIEVER LJ, AMIN F, COCCARO EF et al. CSF homovanillic acid in schizotypal personality disorder. Am J Psychiatry 1993: 150: 149-151.
75. BLACKWOOD DHR, ST CLAIR DM, KUTCHER SP. P300 event-related potential abnormalities in borderline personality disorder. Biol Psychiatry 1986: 21: 557-560.
76. VITA A, SACCHETTI E, BATTAGLIA M et al. Cerebral ventricular enlargement in personality disorders. Abstract. In: Psychiatry and its related disciplines. World Psychiatric Association Regional Symposium, 1986. Copenhagen: Book of Abstracts, 1986: 198.
77. MCGUFFIN P, THAPAR A. The genetics of personality disorders. Br J Psychiatry 1992: 160: 12-23.
78. FARMER A, MCGUFFIN P, GOTTESMAN II. Twin concordance for DSM-III schizophrenia. Scrutinizing the validity of the definition. Arch Gen Psychiatry 1987: 44: 634-641.
79. GOTTESMAN II, SHIELDS J. Schizophrenia and genetics: a twin study vantage point. New York: Academic Press, 1972.
80. KENDLER KS. Limitations of the ratio of concordance rates in monozygotic and dizygotic twins. Arch Gen Pychiatry 1989: 46: 477-478.
81. RISCH N, BARON M. Segregation analysis of schizophrenia and related disorders. Am J Hum Gen 1984: 36: 1039-1059.
82. BARON M, RISCH N. The spectrum concept of schizophrenia: evidence for a genetic-environmental continuum. J Psychiatr Res 1987: 21:257-267.
83. MCGUE M, GOTTESMAN II, RAO DC. The transmission of schizophrenia under a multifactorial threshold model. Am J Hum Genet 1983: 35: 1161-1178.
84. TSUANG MT, BUCHER KD, FLEMING JA. A search for schizophrenia spectrum disorders. An application of a multiple threshold model to blind family study data. Br J Psychiatry 1983: 143: 572-577.
85. BARON M, GRUEN R, ASNIS L, KANE J. Familial relatedness for schizophrenia and schizotypal states. Am J Psychiatr 1983; 140: 1437-1442.
86. BATTAGLIA M, BELLODI L. Schizotypy in the partners of patients with schizolypal personality disorder. Psychiatr Res 1992: 41: 283-285.
87. LEVINSON DF, MOWRY BJ. Defining the schizophrenia spectrum: issues for genetic linkage studies. Schizophr Bull 1991: 17: 491-514.
88. FARAONE SV, KREMEN WS, LYONS MJ, PEPPLE JR, SEIDMAN LJ, TSUANG MT. Diagnostic accuracy and linkage analysis: how useful are schizophrenia spectrum phenotypes? Am J Psychiatry 1995: 152: 1286-1290.
89. KENDLER KS, NEALE MC, WALSH D. Evaluating the spectrum concept of schizophrenia in the Roscommon Family Study. Am J Psychiatry 1995: 152: 749-754.
90. BATTAGLIA M, CAVALLINI MC, MACCIARDI F, BELLODI L. The structure of DSM-III-R schizotypal disorder diagnosed by direct interviews. Results from confirmatory factor analysis of patient and non-patient subjects. Schizophr Bull 1996: 22 (in press).
91. PARNAS J, JORGENSEN A. Pre-morbid psychopathology in schizophrenia spectrum. BrJ Psychiatry 1989: 155: 623-627.
92. KENDLER KS, MCGUIRE M, GRUENBERG AM, WALSH D. Schizotypal symptoms and signs in the Roscommon family study. Arch Gen Psychiatry 1993: 52: 296-303.
93. WIDIGER TA, FRANCES AJ, TRULL TJ. A psychometric analysis of the social-interpersonal and cognitive-perceptual items for the schizotypal personality disorder. Arch Gen Psychiatry 1987: 44: 741-745.
94. STONE M. Schizotypal personality: psychotherapeutic aspects. Schizophr Bull 1985: 11: 576-589.