Astrocyte-derived nitric oxide causes both reversible and irreversible damage to the neuronal mitochondrial respiratory chain

Journal of Neurochemistry

Volumn 75, Issue 2, 2000, Pages 694-700

  Stewart, Victoria C ^a   Sharpe, Martyn A ^a   Clark, John B ^a   Heales, Simon J R ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

Author keywords

Astrocyte; Coculture; Mitochondrial respiratory chain; Neuron; Nitric oxide; Reversibility

Indexed keywords

NITRIC OXIDE;

ANIMAL CELL; ARTICLE; ASTROCYTE; DEGENERATIVE DISEASE; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; CITRATE (SI)-SYNTHASE; COCULTURE TECHNIQUES; ELECTRON TRANSPORT COMPLEX II; ELECTRON TRANSPORT COMPLEX III; ELECTRON TRANSPORT COMPLEX IV; KINETICS; MITOCHONDRIA; MULTIENZYME COMPLEXES; NADH DEHYDROGENASE; NEURONS; NITRATES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OXIDANTS; OXIDOREDUCTASES; OXYGEN CONSUMPTION; RATS; RATS, WISTAR; SUCCINATE DEHYDROGENASE;

ANIMALIA;

EID: 0033914409     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0750694.x     Document Type: Article

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