Sexual dysfunction in depression

Human Psychopharmacology

Volumn 15, Issue 5, 2000, Pages 337-345

  Michael, Albert ^a   O'Keane, Veronica ^b  

^a WEST SUFFOLK HOSPITAL   (United Kingdom)

^b BEAUMONT HOSPITAL   (Ireland)

Author keywords

Depression; Sexual dysfunction

Indexed keywords

HORMONE; NEUROTRANSMITTER;

DEPRESSION; HUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; SEXUAL DYSFUNCTION;

EID: 0033914012     PISSN: 08856222     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-1077(200007)15:5<337::AID-HUP207>3.0.CO;2-H     Document Type: Review

References (101)

1. Adler RA. 1986. The anterior pituitary-grafted rat: a valid model of chronic hyperprolactinaemia. Endocrine Rev 7: 302-313.
2. Amsterdam JD, Winokur A, Caroff S, Snyder P. 1981. Gonadotropin release after administration of GnRH in depressed patients and healthy volunteers. J Affect Disord 3: 367-380.
3. Amsterdam JD, Winokur A, Luki I, Caroff S, Snyder P, Rickels KA. 1983a. A neuroendocrine test battery in bipolar patients and healthy subjects. Arch Gen Psychiatry 40: 515-521.
4. Amsterdam JD, Winokur A, Lucki I, Snyder P. 1983b. Neuroendocrine regulation in depressed postmenopausal women and healthy controls. Acta Psychiatr Scand 67: 43-49.
5. Amsterdam JD, Maislin G, Rosenzweig M, Halbrecht U. 1995. Gonadotropin (LH and FSH) response after submaximal GnRH stimulation in depressed premenopausal women and healthy controls. Psychoneuroendocrinology 20: 311-321.
6. Armario A, Marti O, Molina T, de Pablo J, Valdes M. 1996. Acute stress markers in humans: response of plasma glucose, cortisol and prolactin to two examinations differing in the anxiety they provoke. Psychoneuroendocrinology 21: 17-24.
7. Bamforth KJ, Dalgliesh K, Coughtrie WMH. 1992. Inhibition of human liver steroid sulfotransferase activities by drugs: a novel mechanism of drug toxicity? Eur J Pharmacol 228: 15-21.
8. Bancroft J, Sherwin BB, Alexander GM, Davidson DW, Walker A. 1991. Oral contraceptives, androgens and sexuality of young women: II. The role of androgens. Arch Sex Behav 20: 121-135.
9. Barabarino A, De Maranis L, Tofani B. 1986. Corticotrophin-releasing hormone inhibition of gonadotropin release and the effects of opioid blockade. J Clin Endocrinol Metab 68: 523-528.
10. Beck AT. (ed.). 1967. Depression: Clinical, Experimental and Theoretical Aspects. Harper and Row: New York.
11. Bhishagrathna KK. (ed.). 1968. Sushruta Samhita (English translation). Chowkhamba Sanskrit Samatan: Varanasi.
12. Brambilla F, Smeraldi E, Sacchetti E, Negri F, Cocchi D, Muller EE. 1978. Deranged anterior pituitary responsiveness to hypothalamic hormones in depressed patients. Arch Gen Psychiatry 35: 1231-1238.
13. Brambilla F, Maggioni M, Ferrari E, Scarone S, Catalano M. 1990. Tonic and dynamic gonadotropin secretion in depressive and normothymic phases of affective disorders. Psychiatry Res 32: 229-239.
14. Brincat M, Magos AL, Studd JWW, Cardozo LS, O'Dowd T, Wardle PJ, Cooper D. 1984. Subcutaneous hormone implants for the control of climacteric symptoms. Lancet i: 16-18.
15. Brown RP, Sweeney J, Loutsch E, Kocsis J, Frances A. 1984. Involutional melancholia revisited. Am J Psychiatry 141: 24-28.
16. Brown GM, Steiner M, Grof P. 1988. Neuroendocrinology of affective disorders. In Clinical Endocrinology, Collu R, Brown GM, Van Loon GR (eds). Blackwell Scientific: London; 461-475.
17. Carette B, Poulain P. 1984. Excitatory effect of dehydroepiandrosterone and its sulphate ester and pregnenolone sulphate, applied by iontophoresis and pressure, on single neurones in the septo-preoptic area of guinea pig. Neurosci Lett 45: 205-210.
18. Casper RC, Redmond DE, Katz MM, Schaffer CB, Davis JM, Koslow SH. 1985. Somatic symptoms in primary affective disorder: presence and relationship to the classification of depression. Arch Gen Psychiatry 42: 1098-1104.
19. Casper RC, Katz MM, Bowden CL, Davis JM, Koslow SH, Hanin I. 1994. The pattern of physical symptom changes in major depressive disorder following treatment with amitriptyline or imipramine. J Affect Disord 31: 151-164.
20. Cassidy WL, Flanagan NB, Spellman M, Cohen ME. 1957. Clinical observations in manic depressive disease: a quantitative study of 100 manic depressive patients and 50 medically sick controls. JAMA 164: 1535-1546.
21. Cawood EH, Bancroft J. 1996. Steroid hormones, the menopause, sexuality and well-being of women. Psychol Med 26: 925-936.
22. Charpenet G, Tache Y, Forest MG, Hanour F, Saez JM, Bernier M, Ducharme JR, Collu R. 1981. Effects of chronic intermittent immobilization stress on rat testicular androgenic function. Endocrinology 109: 1254-1258.
23. Charpenet G, Tache Y, Bernier M, Ducharme JR, Collu R. 1982. Stress-induced testicular hyposensitivity to gonadotropin rats. Role of the pituitary gland. Biol Reprod 27: 616-623.
24. Clopper RR, Voorhess ML, MacGillivray MH, Lee PA, Mills B. 1993. Psychosexual behavior in hypopituitary men: a controlled comparison of gonadotropin and testosterone replacement. Psychoneuronendocrinology 18: 149-161.
25. Coppen A. 1965. The prevalence of menstrual disorders in psychiatric patients. Br J Psychiatry 111: 155-167.
26. Crenshaw TL, Goldberg JP (eds). 1996. Sexual Pharmacology. WW Norton: New York.
27. Davies RH, Harris B, Thomas DR, Cook N, Read G, Riad-Fahmy D. 1992. Salivary testosterone levels and major depressive illness in men. Br J Psychiatry 161: 629-632.
28. Derogatis LR, Meyer JK, King KM. 1981. Psychopathology in individuals with sexual dysfunction. Am J Psychiatry 138: 757-763.
29. Devesa J, Perez-Fernandez R, Bokser L, Casanueva FF. 1988. Adrenal androgen secretion and dopaminergic activity in anorexia nervosa. Horm Metab Res 20: 57-60.
30. Dinan TG. 1994. Glucocorticoids and the genesis of depressive illness: a psychobiological model. Br J Psychiat 164: 365-271.
31. Donahey KM, Carroll RA. 1993. Gender differences in factors associated with hypoactive sexual desire. J Sex Marital Ther 19: 25-40.
32. Driscoll R, Thompson C. 1993. Salivary testosterone levels and major depressive illness in men. Br J Psychiat 163: 122-123.
33. Dubrovsky B. 1997. Natural steroids counteracting some actions of putative depressogenic steroids on the central nervous system: potential therapeutic benefits. Med Hypotheses 49: 51-55.
34. Duncan JA, Barkan A, Herbon L, Marshall JC. 1986. Regulation of pituitary GnRH receptors by pulsatile GnRH in female rats: effects of estradiol and prolactin. Endocrinology 118: 320-327.
35. Ende J, Rockwell S, Glasgow M. 1984. The sexual history in general medicine practice. Arch Intern Med 144: 558-561.
36. Escobar JI, Gomez J, Tauson VB. 1983. Depressive phenomenology in North and South American patients. Am J Psychiatry 140: 47-51.
37. Ettigi PG, Brown GM, Seggi JA. 1979. TSH and LH responses in subtypes of depression. Psychosomatic Med 41: 203-208.
38. Fagan PJ, Schmidt CW, Wise TN, Derogatis LR. 1988. Sexual dysfunction and dual psychiatric diagnoses. Compr Psychiatry 29: 278-284.
39. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. 1994. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Ageing Study. J Urol 151: 54-61.
40. Goodyer IM, Herbert J, Altham PME, Pearson J, Secher SM, Shiers HM. 1996. Adrenal secretion during major depression in 8-year-olds to 16-year-olds. 1. Altered diurnal rhythms in salivary cortisol and dehydroepiandrosterone (DHEA) at presentation. Psychol Med 26: 245-256.
41. Gray A, Feldman HA, McKinlay JB, Longcope C. 1991. Age, disease, and changing sex hormone levels in middle-aged men. Results of the Massachusetts male Aging study. J Clin Endocrinol Metab 73: 1016-1025.
42. Gregoire AJP, Kumar R, Everitt B, Henderson AF, Studd JWW. 1996. Transdermal oestrogen of treatment of severe postnatal depression. Lancet 347: 930-933.
43. Guazzo EP, Kirkpatrick PJ, Goodyer IM, Shiers HM, Herbert J. 1996. Cortisol, dehydroepiandrosterone (DHEA), and DHEA sulphate in the cerebrospinal fluid of man: relation to blood levels and the effects of age. J Clin Endocrinol Metab 81: 3951-3960.
44. Herbert J, Goodyer IM, Altham PME, Pearson J, Secher SM, Shiers HM. 1996. Adrenal secretion during major depression in 8-year-olds to 16-year-olds. 2. Influence of comorbidity at presentation. Psychol Med 26: 257-263.
45. Huerta R, Mena A, Malacara JM, de Leon J. 1995. Symptoms at perimenopausal period: its association with attitudes toward sexuality, life-style, family function and FSH levels. Psychoneuronendocrinology 20: 135-148.
46. Hunter R, Christie JE, Whalley J, Bennie S, Carroll H, Dick H, Goodwin GM, Wilson H, Fink G. 1989. Luteinizing hormone responses to luteinizing hormone-releasing hormone in acute mania and the effects of lithium on LHRH and thyrotropin releasing hormone tests in volunteers. Psychol Med 19: 69-77.
47. Jeffcoate W, Silverstone JT, Edwards CR, Besser GM. 1979. Psychiatric manifestations of Cushing's syndrome: response to lowering of plasma cortisol. Q J Med 48: 465-472.
48. Johnson M, Everitt B. 1991. The regulation of gonadal function. In Essential Reproduction. Blackwell Scientific: Oxford; 101-155.
49. Kalra SP, Gallo RV. 1983. The effects of intraventricular catecholamines on lutenising hormone release in morphine treated rats. Endocrinology 113: 23-28.
50. Kellett JM. 1996. Sex and the elderly male. Sex Marital Ther 11: 281-288.
51. Kendall DA, Stancel AM, Enna SJ. 1981. Imipramine: effect of ovarian steroids on modification in serotonin receptor binding. Science 211: 1183-1185.
52. Kinsey AC, Pomeroy WB, Martin CE (eds). 1948. Sexual Behaviour in the Human Male. WB Saunders: Philadelphia.
53. Kinsey AC, Pomeroy WB, Martin CE, Gebhard PH (eds). 1953. Sexual Behaviour in the Human Female. WB Saunders: Philadelphia.
54. Kivela SL, Pahkala K. 1988. Clinician-rated symptoms and signs of depression in aged Finns. Int J Soc Psychiatry 4: 274-284.
55. Klaiber EL, Broverman DM, Vogel W, Kobayashi Y. 1979. Estrogen therapy for severe persistent depression in women. Arch Gen Psychiatry 36: 742-747.
56. Krishnan KRR, France RD, Pelton S, McCann UD, Manepalli AN, Davidson JRT. 1985. What does the dexamethasone suppression test identify? Biol Psychiatry 20: 957-964.
57. Leedy MG, Wilson MS. 1985. Testosterone and cortisol levels in crewmen of U.S. Airforce fighter and cargo planes. Psychosom Med 47: 333-338.
58. Leonard BE, Healy D (eds). 1999. Differential Effects of Antidepressants. Martin Dunitz: London.
59. Levitt AJ, Joffe RT. 1988. Total and free testosterone in depressed men. Acta Psychiatr Scand 77: 346-348.
60. MacAdams MR, White RH, Chipps BE. 1986. Reduction of serum testosterone levels during chronic glucocorticoid therapy. Ann Intern Med 104: 648-651.
61. Mathew RJ, Weinman M, Claghorn JL. 1980. Tricyclic side effects without tricyclics in depression. Psychopharmacol Bull 16: 58-60.
62. Meller WH, Zander KM, Crosby RD, Tagatz GE. 1997. Lutenising hormone pulse characteristics in depressed woman. Am J Psychiatry 154: 1454-1455.
63. Miller KB, Nelson JC. 1987. Does the dexamethasone suppression test relate to subtypes, factors, symptoms or severity? Arch Gen Psychiatry 44: 769-774.
64. Mills IH. 1979. The role of arousal and failure of coping in sexual functions. Br J Clin Pract 33 (suppl. 4): 18-22.
65. Morris NM, Udry JR, Khan-Dawood MY. 1987. Marital sex frequency and midcycle female testosterone. Arch Sex Behav 16: 27-37.
66. Nathan S. 1986. Epidemiology of DSM-III psychosexual dysfunctions. J Sex Marital Ther 12: 267-281.
67. Nofzinger EA, Thase ME, Reynolds FC, Frank E, Jennings R, Garamoni GL, Fasiczka AL, Kupfer DJ. 1993. Sexual function in depressed men: assessment by self-report, behavioural, and nocturnal penile tumescence measures before and after treatment with cognitive behavior therapy. Arch Gen Psychiatry 50: 24-30.
68. Osran H, Reist C, Chen CC, Lifrak ET, Chicz-DeMet A, Parker LN. 1993. Adrenal androgens and cortisol in major depression. Am J Psychiatry 150: 806-809.
69. Paykel ES. 1977. Depression and appetite. J Psychosom Res 21: 401-407.
70. Pollitt JD. 1960. Depression and the functional shift. Comprehen Psychiatry 1: 381-390.
71. Poison DW, Sagle M, Mason HD, Adams J, Jacobs HS, Franks S. 1986. Ovulation and normal luteal function during LHRH treatment of women with hyperprolactinaemic amenorrhoea. Clin Endocrinol 24: 531-537.
72. Ray P, Gupta HN. 1965. Charaka Samhita: A Scientific Synopsis. National Institute of Science of India: New Delhi.
73. Reame NE, Saunder SE, Case GD. Kelch RP, Marshall JC. 1985. Pulsatile gonadotropin secretion in women with hypothalamic amenorrhoea: evidence that reduced frequency of gonadotropin-releasing hormone secretion is the mechanism of persistent anovulation. J Clin Endocrinol Metab 61: 851-858.
74. Reus VI. 1982. Pituitary-adrenal disinhibition as the independent variable in the assessment of behavioral symptoms. Biol Psychiatry 17: 317-326.
75. Robel P, Baulieu EE. 1985. Neurosteroids: 3 beta-hydroxy-5-derivatives in the rodent brain. Neurochem Int 7: 953-958.
76. Rubin RT, Poland RE, Tower BB, Hart PA, Blodgett ALN, Forster B. 1981. Hypothalamo-pituitary-gonadal function in primary endogenously depressed men: preliminary findings. In Steroid Hormone Regulation of the Brain, Fuxe K, Gustafsson JA, Wetterberg L (eds). Pergamon Press: Oxford; 387-396.
77. Rubin AL, Price LH, Charney DS, Heninger GR. 1985. Noradrenergic function and the cortisol response to dexamethasone in depression. Psychiat Res 15: 5-15.
78. Rubin RT, Poland RE, Lesser IM. 1989. Neuroendocrine aspects of primary endogenous depression VII. Pituitary-gonadal axis activity in male patients and matched controls. Psychoneuroendocrinology 14: 217-229.
79. Saletu B, Brandstatter N, Metka M, Stamenkovic M, Anderer P, Semlitch HV, Hegtmanek G, Huber J, Grunberger J, Linzmayer L, Kurz C, Decker K, Binder G, Knogler W, Koll B. 1996. Hormonal, syndromal and EEG mapping studies in menopausal syndrome patients with and without depression as compared to controls. Maturitas 23: 91-105.
80. Santoro N, Filicori M, Crowley WF Jr. 1986. Hypogonadotropic disorders in men and women: diagnosis and therapy with pulsatile gonadotropin-releasing hormone. Endocrine Rev 7: 11-23.
81. Sapolsky PM. 1982. The endocrine stress response and social status in the wild baboon. Horm Behav 16: 279-292.
82. Saunder SE, Frager M, Case GD, Kelch RP, Marshall JC. 1984. Abnormal patterns of pulsatile lutenising hormone secretion in women with hyperprolactinaemia and amenorrhoea - responses to bromocriptine. J Clin Endocrinol Metab 59: 941-948.
83. Schreiner-Engel P, Schiavi RC. 1986. Lifetime psychopathology in individuals with low sexual desire. J Nerv Ment Dix 174: 646-651.
84. Sherwin BB. 1994. Impact of changing hormonal milieu on psychological functioning. In Treatment of Postmenopausal Women: Basic Clinical Aspects, Lobo RA (ed.). Raven Press: New York; 119-127.
85. Steiger A, Von Bardeleben U, Wiedemann K, Holsboer F. 1991. Sleep EEG and nocturnal secretion of testosterone and cortisol in patients with major endogenous depression during acute phase and after remission. J Psychiat Res 25: 169-177.
86. Studd JWW, Collins WP, Chakravarti S, Newton JR, Oram D, Parsons A. 1977. Oestradiol and testosterone implants in the treatment of psychosexual problems in the postmenopausal women. Br J Obstet Gynaecol 84: 314.
87. Tamburello A, Seppecher MF. 1977. The effects of depression on sexual behavior: preliminary results of research. In Progress in Sexology, Gerome R, Wheeler CC (eds). Plenum Press: New York; 107-128.
88. Tay CCK, Glasier AF, Illingworth PJ, Baird DT. 1993. Abnormal twenty-four hour pattern of pulsatile luteinizing hormone secretion and the response to nalaxone infusion in women with hyperprolactinaemic amenorrhoea. Clin Endocrinol 39: 599-606.
89. Thompson JW, Ware MR, Blashfield RK. 1990. Psychotropic medication and priapism. J Clin Psychiatry 51: 430-433.
90. Tiwary CM. 1974. Testosterone, LHRH and behavior. Lancet i: 993.
91. Vogel W, Klaiber EL, Broverman DM. 1985. A comparison of the antidepressant effects of a synthetic androgen (mesterolone) and amitriptyline in depressed men. J Clin Psychiatry 46: 6-8.
92. Wagner HR, Crutcher KA, Davis JN. 1979. Chronic estrogen treatment decreases beta-adrenergic responses in rat cerebral cortex. Brain Res 71: 147-151.
93. Watson NR, Studd JWW, Garnet T, Baker RJ. 1989. A randomised placebo controlled study of transdermal oestradiol patches for the treatment of premenstrual syndrome. Lancet iii: 730-732.
94. Weiner RJ, Ganong WF. 1978. Role of brain monoamine and histamine in regulation of anterior pituitary secretion. Physiol Rev 58: 905-907.
95. Weissman MM, Paykel ES. 1974. The Depressed Woman: A Study of Social Relationships. University of Chicago Press: Chicago
96. Whalley LJ, Kutcher DH, Blackwood DHR, Bennie J, Dick H, Fink G. 1987. Increased plasma LH in manic-depressive illness: evidence of a state-independent abnormality. Br J Psychiatry 150: 682-684.
97. Williams RB, Lane JD, Kuhu CM, Melogh W, White AD, Schanberg SM. 1982. Type A behaviour and elevated physiological and neuroendocrine responses to cognitive tasks. Science 218: 483-485.
98. Winokur G, Clayton PJ, Reich T. 1969. Manic Depressive Illness. CV Mosby: St Louis.
99. Winterer J, Gwirtsman HE, George DT, Cutler B Jr. 1985. Adrenocorticotropin-stimulated adrenal secretion in anorexia nervosa: impaired secretion at low weight with normalization after long-term recovery. J Clin Endocrinol Metab 61: 693-697.
100. Wolkowitz OM, Reus VI, Roberts E. 1995. Antidepressant and cognition enhancing effects of DHEA in major depression. Ann NY Acad Sci 774: 337-339.
101. Woolf PD, Hamill RW, McDonald JV, Lee LA, Kelly M. 1985. Transient hypogonadotropic hypogonadism caused by critical illness. J Clin Endocrinol Metab 60: 444-450.