Cellular effects of ventilator-induced lung injury

Current Opinion in Critical Care

Volumn 6, Issue 1, 2000, Pages 71-74

  Zhang, Haibo ^a   Ranieri, V Marco ^b   Slutsky, Arthur S ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT RESPIRATORY DISTRESS SYNDROME; ARTIFICIAL VENTILATION; EFFECTOR CELL; HUMAN; INFLAMMATION; LUNG COLLAPSE; LUNG INJURY; MEDIATOR RELEASE; REVIEW; RISK FACTOR;

EID: 0033913276     PISSN: 10705295     EISSN: None     Source Type: Journal    
DOI: 10.1097/00075198-200002000-00010     Document Type: Review

References (20)

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16. 16 Ranieri VM, Suter PM, Tortorella C, De Tullio R, Dayer JM, Brienza A, Bruno F, Slutsky AS: Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome. JAMA 1999, 282:54-61. The first clinical study demonstrating that a variety of cytokines remain elevated in bronchoalveloar lavage fluid and serum of patients with ARDS receiving conventional mechanical ventilation, but progressively decreased in patients receiving a lung-protective ventilatory strategy.
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18. 18 National Institutes of Health/National Heart, Lung, and Blood Institute ARDS Network: http://hedwig.mgh.harvard.edu/ardsnet/ards01.html. An important clinical trial comparing low tidal volume to high tidal volume in ARDS patients, with a significant survival rate in the low tidal volume group.
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