Evidence for the differential regulation of Nkx-6. 1 Expression in the ventral spinal cord and foregut by Shh-dependent and -independent mechanisms

Genesis

Volumn 27, Issue 1, 2000, Pages 6-11

  Cai, Jun ^a   Xu, Xiaohua ^a   Yin, Huliang ^a   Wu, Rachel ^a   Modderman, Geoffrey ^a   Chen, YiPing ^b   Jensen, Jan ^c   Hui, Chi Chung ^d   Qiu, Mengsheng ^a  

^a University of Louisville School of Medicine   (United States)

^b Tulane University   (United States)

^c HAGEDORN RESEARCH INSTITUTE   (Denmark)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Esophagus; Expression pattern; Lateral motoneuron column; Meninges; Nkx 6.1; Shh

Indexed keywords

HOMEODOMAIN PROTEIN; RNA; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NKX 6.1; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL FATE; CHICK EMBRYO; CONTROLLED STUDY; DIGESTIVE SYSTEM; EMBRYO; EMBRYO DEVELOPMENT; ESOPHAGUS; GENE EXPRESSION REGULATION; HOMEOBOX; IN SITU HYBRIDIZATION; MENINX; MESENCHYME; MOTONEURON; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD; TRACHEA;

ANIMALS; CHICK EMBRYO; ESOPHAGUS; EYE PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; MOTOR NEURONS; NERVE TISSUE PROTEINS; PROTEINS; SPINAL CORD; TRANS-ACTIVATORS;

EID: 0033911270     PISSN: 1526954X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1526-968X(200005)27:1<6::AID-GENE20>3.0.CO;2-O     Document Type: Article

References (17)

1. Bitgood M, McMahon A. 1995. Hedgehog and BMP genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol 172:126-138.
2. Cai J, St Amand T, Yin H, Guo H, Li G, Zhang Y, Chen Y, Qiu M. 1999. Expression and regulation of the chicken Nkx-6.2 homeobox gene suggest its possible involvement in the ventral neural patterning and cell fate specification. Dev Dyn 216:459-468.
3. Chiang C, Litingtung Y, Lee E, Young K, Corden J, Westphal H, Beachy PA. 1996. Cyclopia and defective axial patterning in mice lacking sonic hedgehog gene function Nature 383:407-413.
4. Ding Q, Motoyama J, Gasca S, Mo R, Sasaki H, Rossant J, Hui C-C. 1998. Diminished Sonic hedgehog signaling and lack of door plate differentiation in Gli2 mutant mice. Development 125:2533-2543.
5. Jensen J, Serup P, Karlsen C, Nielsen T, Madse O. 1996. mRNA profiling of rat islet tumors reveals Nkx6.1 as a beta-cell-specitic homeodomain transcription factor. J Biol Chem 271:18749-18758.
6. Litingtung Y, Lei L, Westphal H, Chiang C. 1998. Sonic hedgehog is essential to foregut development. Nature Genet 20:58-61.
7. Matise M, Epstein D, Park H, Platt K, Joyner A. 1998. Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development 125: 2759-2770.
8. Pfaff S, Kintner C. 1998. Neuronal diversification: development of motor neuron subtypes. Curr Opin Neurobiol 8:27-36.
9. Qiu M, Shimamura K, Sussel L, Chen S, Rubenstein J. 1998. Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development. Mech Dev 72:77-88.
10. Roberts DJ, Johnson RL, Burke AC, Nelson CE, Morgan BA, Tabin C. 1995. Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut. Development 121:3163-3174.
11. Roberts D, Smith D, Goff D, Tabin, C. 1998. Epithelial-mesenchymal signaling during the regionalization of the chick gut. Development 125:2791-2801.
12. Rudnick A, Ling TY, Odagiri H, Rutter W, German M. 1994. Pancreatic beta cells express a diverse set of homeobox genes. Proc Natl Acad Sci USA 91:12203-12207.
13. Schaeren-Wiemers N, Gerfin-Moser A. 1993. A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labeled cRNA probes. Histochemistry 100:431-440.
14. Shimamura K, Hartigan DJ, Martinez S, Puelles L, Rubenstein JI. 1995. Longitudinal organization of the anterior neural plate and neural tube. Development 121:3923-3933.
15. Sockanathan S, Jessell TM. 1998. Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons. Cell 94:503-514.
16. Sussel L, Kalamaras J, Hartigan-O'connor D. Meneses J, Pedersen R, Rubenstein J, German M. 1998. Mice lacking the homeodomain transcription factor Nkx-2.2 have diabetes due to arrested differentiation of pancreatic β cells. Development 125:2213-2221.
17. Tsuchida T, Ensin M, Morton S, Baldassare M, Edlund T, Jessell T, Pfaff SL. 1994. Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes. Cell 79:957-970.