Induction of mdm2-P2 transcripts correlates with stabilized wild-type p53 in betel- and tobacco-related human oral cancer

American Journal of Pathology

Volumn 157, Issue 2, 2000, Pages 587-596

  Ralhan, Ranju ^a   Sandhya, Agarwal ^a   Meera, Mathur ^a   Bohdan, Wasylyk ^b   Nootan, Shukla K ^a  

^a INSTITUTE ROTARY CANCER HOSPITAL   (India)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; PROTEIN MDM2; PROTEIN P53;

ADULT; ARTICLE; BETEL NUT; CANCER SURVIVAL; FEMALE; GENE AMPLIFICATION; GENE LOCATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RNA TRANSLATION; SQUAMOUS CELL CARCINOMA; TOBACCO;

EID: 0033903436     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64569-5     Document Type: Article

References (28)

1. Amplification of a gene encoding a p53-associated protein in human sarcomas
2. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
3. p53 mutation and mdm2 amplification in human soft tissues sarcomas
4. Amplification and overexpression of the mdm2 gene in a subset of human malignant gliomas without p53 mutations
5. Tumorigenic potential associated with enhanced expression of a gene that is amplified in mouse tumor cell line
6. The mdm2 oncogene can overcome wild-type p53 suppression of transformed cell growth
7. Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene
8. Regulation of mdm2 expression by p53: Alternative promoters produce transcripts with nonidentical translation potential
9. A functional p53-responsive intronic promoter is contained within the human mdm-2 gene
10. Identification and characterization of multiple MDM2 proteins and MDM2 -p53 protein complexes
11. MDM2 protein is expressed in different layers of normal human skin
12. The ribosomal L5 protein is associated with mdm2 and mdm2 -p53 complexes
13. The MDM2 oncoprotein binds specifically to RNA through its RING finger domain
14. The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter
15. Risk factors and risk markers for oral cancer in high risk areas of the world
16. MDM2/p53 co-expression in oral premalignant and malignant lesions: Potential prognostic implications
17. Single-step method of RNA isolation by acid guanidiniumthiocyanate-phenol-chloroform extraction
18. Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein
19. Mutations and polymorphisms in the p53, p21 and p16 genes in oral carcinomas of India betel quid chewers
20. p53 gene mutations in oral carcinomas from India
21. Overexpression of MDM2, due to enhanced translation, results in activation of wild-type p53 in Burkitt's lymphoma cells
22. The p53-MDM2 interaction in a cancer-prone family, and the identification of a novel therapeutic target
23. Physical and functional interaction between wild-type p53 and MDM2 proteins
24. Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: Transforming ability and frequent detection in human cancer
25. Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein
26. Interaction between the retinobtastoma protein and the oncoprotein MDM2
27. Selective compartmentalization of different MDM2 proteins within the nucleus
28. A molecular and immunohistochemical study of MDM2 proteins and p53 gene product in bronchogenic carcinoma