The thromboxane A2 and K(ATP) channel antagonist actions of a series of sulphonylurea derivatives in the pig coronary artery

European Journal of Pharmacology

Volumn 324, Issue 2-3, 1997, Pages 193-200

  McPherson, Grant A ^a   Choi, Rachel T ^a   Kong, David C M ^a   Iskander, Magdy N ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Coronary artery, pig; Levcromakalim; Structure activity relationship; Sulphonylurea; Thromboxane A2

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETYLCHOLINE; GLIBENCLAMIDE; LEMAKALIM; POTASSIUM CHANNEL; SULFONYLUREA DERIVATIVE; BENZOPYRAN DERIVATIVE; CATION; CROMAKALIM; DRUG DERIVATIVE; ORGANOPHOSPHORUS COMPOUND; PROSTAGLANDIN ENDOPEROXIDE; PYRROLE DERIVATIVE; TETRAPHENYLPHOSPHONIUM; THROMBOXANE A2; VASOCONSTRICTOR AGENT; VASODILATOR AGENT;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; REGRESSION ANALYSIS; STRUCTURE ACTIVITY RELATION; ANIMAL; CORONARY BLOOD VESSEL; DRUG ANTAGONISM; DRUG EFFECT; SWINE;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; BENZOPYRANS; CORONARY VESSELS; CROMAKALIM; GLYBURIDE; ONIUM COMPOUNDS; ORGANOPHOSPHORUS COMPOUNDS; POTASSIUM CHANNELS; PROSTAGLANDIN ENDOPEROXIDES, SYNTHETIC; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; THROMBOXANE A2; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 0030609857     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)00086-1     Document Type: Article

References (12)

1. Aguilar-Bryan, L., C.G. Nichols, S.W. Wechsler, J.P. Clement IV, A.E. Boyd III, G. Gonzalez, H. Herrera-Sosa, K. Nguy, J. Bryan and D.A. Nelson, 1995, Cloning of the β cell high-affinity sulfonylurea receptor: a regulator of insulin secretion, Science 268, 423.
2. Ashcroft, S.H. and F.M. Ashcroft, 1990, Properties and functions of ATP-sensitive K-channels, Cell Signal 2, 197.
3. Birnbaumer, L., 1992, G proteins and the modulation of potassium channels, in: Potassium Channel Modulators, eds. A.H. Weston and T.C. Hamilton (Blackwell Scientific Publications, Oxford) p. 44.
4. Challinor-Rogers, J.L. and G.A. McPherson, 1993, Evidence that imidazol(id)ine- and sulphonylurea-based antagonists of cromakalim act at different sites in the rat thoracic aorta, Clin. Exp. Pharmacol. Physiol. 20, 467.
5. ATP channels, Clin. Exp. Pharmacol. Physiol. 21, 583.
6. 3H]-glibenclamide binding to membranes from rat cerebral cortex, J. Pharmacol. Exp. Ther. 273, 778.
7. 2 receptor in dog coronary artery in vitro, Br. J. Pharmacol. 100, 375.
8. Coleman, R.A., W.L. Smith and S. Narumiya, 1994, VIII. International Union of Pharmacology classification of prostanoid receptors: properties, distribution and structure of the receptors and their subtypes, Pharmacol. Rev. 46, 205.
9. Delaey, C. and J. Van de Voorde, 1995, Prostanoid-induced contractions are blocked by sulphonylureas, Eur. J. Pharmacol. 280, 179.
10. + channel and linkage studies with NIDDM in Japanese, Diabetes 45, 267.
11. Kenakin, T.P., 1987, Pharmacologic Analysis of Drug-Receptor Interaction (Raven Press, New York, NY) p. 205.
12. + channel opener, levcromakalim, in vascular smooth muscle, Br. J. Pharmacol. 112, 1223.