Effects of a pure antiestrogen on apoptosis and proliferation within human breast ductal carcinoma in situ

Cancer Research

Volumn 60, Issue 15, 2000, Pages 4284-4288

  Gandhi, A ^a   Holland, P A ^a   Knox, W F ^a   Potten, C S ^a   Bundred, N J ^a  

^a MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR; FULVESTRANT;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CELL DEATH; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; ESTROGEN THERAPY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; XENOGRAFT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CARCINOMA IN SITU; CELL DIVISION; ESTRADIOL; ESTROGEN RECEPTOR MODULATORS; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; MIDDLE AGED; NEOPLASM TRANSPLANTATION; RECEPTORS, ESTROGEN; TRANSPLANTATION, HETEROLOGOUS;

EID: 0033891772     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Incidence of and treatment for ductal carcinoma in situ of the breast
2. Lumpectomy and radiation therapy for the treatment of intraductal breast cancer: Findings from national surgical adjuvant breast and bowel project B-17
3. Tamoxifen in treatment of intraductal breast cancer: National Surgical Adjuvant Breast and Bowel Project B-24 randomised controlled trial
4. Tamoxifen for early breast cancer: An overview of the randomised trials
5. The relationship between hormone receptor content and the effect of adjuvant tamoxifen in operable breast cancer
6. Assessment of hormone dependence of comedo ductal carcinoma in situ of the breast
7. Effects of tamoxifen on growth and apoptosis of estrogen-dependent and -independent human breast cancer cells
8. Relationship between tamoxifen-induced transforming growth β 1 expression, cytostasis and apoptosis in human breast cancer cells
9. The proliferation normal human breast tissue implanted into athymic nude mice is stimulated by estrogen but not by progesterone
10. A potent specific pure antioestrogen with clinical potential
11. Comparison of the effects of a pure antiestrogen with those of tamoxifen in a model of human breast cancer
12. Apoptosis. Its significance in cancer therapy
13. Apoptosis, the biochemistry and molecular biology of programmed cell death
14. Evidence of significant apoptosis in ductal carcinoma in situ of the breast
15. Carcinoma in situ
16. Extensive apoptosis in ductal carcinoma in situ of the breast
17. Progestin regulation of cellular proliferation
18. Effects of tamoxifen and 4'-hydroxytamoxifen on the pNR-1 and pNR-2 estrogen-regulated RNAs in human breast cancer cells
19. Comparitive analysis of different approaches to investigate cell kinetics
20. Effect on growth and cell cycle kinetics of estradiol and tamoxifen on MCF-7 human breast cancer cells grown in vitro and in nude mice
21. Apoptosis in toremifene-induced growth inhibition of human breast cancer cells in vivo and in vitro
22. Induction of apoptosis by tamoxifen and ICI 182780 in primary breast cancer
23. In situ end-labeling detects DNA strand breaks in apoptosis and other physiological and pathological states
24. Decreased apoptosis in non-involved tissue from cancer containing breasts
25. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis and autolytic cell death: A cautionary note
26. Two in situ labeling techniques reveal different patterns of DNA fragmentation during spontaneous apoptosis in vivo and induced apoptosis in vitro
27. Apoptosis in murine intestinal crypts
28. What is apoptotic index measuring? A commentary
29. Investigation of a new pure antiestrogen (ICI 182780) in women with primary breast cancer
30. The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice
31. p53 Dependent apoptosis suppresses tumor growth and progression in vivo
32. Apoptosis is inversely related to necrosis and determines net growth in tumors bearing constitutively expressed myc, ras and HPV oncogenes
33. Neu protein overexpression in breast cancer: Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer
34. Tumor-inhibitory monoclonal antibodies to the HER-2/neu receptor induce differentiation of human breast cancer cells
35. Radiolabeled antibody targeting of the HER-2/neu oncoprotein