Targeting the growth hormone axis as a therapeutic strategy in oncology

Growth Hormone and IGF Research

Volumn 10, Issue SUPPL. A, 2000, Pages

  Friend, K E ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; GROWTH HORMONE REALESING HORMONE ANTAGONIST; GROWTH HORMONE RECEPTOR ANTAGONIST; INSULIN LIKE GROWTH FACTOR 1 ANALOG; PEGVISOMANT; RECOMBINANT INSULIN LIKE GROWTH FACTOR BINDING PROTEIN; SOMATOMEDIN C RECEPTOR ANTIBODY; SOMATOSTATIN DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTINEOPLASTIC ACTIVITY; BREAST CANCER; CANCER GROWTH; CARCINOGENESIS; CELL PROLIFERATION; COLON CANCER; COMPETITIVE INHIBITION; CONFERENCE PAPER; GENE MUTATION; HORMONE INHIBITION; HORMONE RELEASE; MENINGIOMA; MITOGENESIS; ONCOLOGY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0033888318     PISSN: 10966374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1096-6374(00)90022-4     Document Type: Conference Paper

References (16)

1. Inhibition of growth, production of insulin-like growth factor-II, and expression of IGF-II mRNA of human cancer cell lines by antagonistic analogs of GH-RH in vitro
2. Octreotide
3. Mechanisim of antineoplastic action of somatostatin analogs
4. Somatostatin analogue SMS 201-995 reduces serum IGF-I levels in patients with neoplasms potentially dependent on IGF-I
5. Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: Mediation by human somatostatin receptor subtypes SSRT1 and SSRT2
6. Growth hormone receptor expression and function in meningioma: Effect of a specific receptor antagonist
7. GH receptor antagonist treatment inhibits growth of human colorectal carcinoma, COLO205 in nude mice
8. Overexpression of human insulin-like growth factor-I receptor promotes ligand-dependent neoplastic transformation
9. Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type I insulin-like growth factor receptor
10. The insulin-like growth factor-I receptor protects tumor cells from apoptosis in vivo
11. Monoclonal antibodies to receptors for insulin and somatomedin-C
12. Tumorigenic and mitogenic capacities are reduced in transfected fibroblasts expressing mutant insulin-like growth factor-I receptors. The role of tyrosine residues 1250, 1251 and 1316 in the carboxy-terminus of the IGF-I receptor
13. Inhibition of cellular proliferation by peptide analogues of insulin-like growth factor-I
14. Inhibition of growth of prostate cancer cell lines by peptide analogues of insulin-like growth factor-I
15. Insulin-like growth factor binding proteins and their role in controlling IGF actions
16. Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) is a potential tumor suppressor protein for prostate cancer