Phage display of peptide epitopes from HIV-1 elicits strong cytolytic responses

Nature Biotechnology

Volumn 18, Issue 8, 2000, Pages 873-876

  De Berardinis, Piergiuseppe ^a   Sartorius, Rossella ^a   Fanutti, Cristina ^b   Perham, Richard N ^b   Del Pozzo, Giovanna ^a   Guardiola, John ^a  

^a INSTITUTE OF PROTEIN BIOCHEMISTRY   (Italy)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

AIDS HIV; CTL; Filamentous bacteriophage fd; MHC class I; Vaccine

Indexed keywords

EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN; RECOMBINANT VACCINE; RNA DIRECTED DNA POLYMERASE;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIOPHAGE; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; HELPER CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VIRUS CAPSID;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; EPITOPES; HIV-1; HUMANS; INOVIRUS; MICE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0033883891     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/78490     Document Type: Article

References (25)

1. Antigen organization regulates cluster formation and induction of cytotoxic T lymphocytes by helper T cell subsets
2. Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors
3. Helper activity is required for the in vivo generation of cytotoxic T lymphocytes
4. Towards development of T-cell vaccines
5. The minimal number of class II MHC-antigen complexes needed for T cell activation
6. Kinetics of generation and persistence on membrane class II molecules of a viral peptide expressed on foreign and self proteins
7. Multiple display of foreign peptides on a filamentous bacteriophage. Peptides from Plasmodium falciparum circumsporozoite protein as antigens
8. Immunological properties of foreign peptides in multiple display on a filamentous bacteriophage
9. Design of specific immunogens using filamentous phage as the carrier
10. Structural mimicry and enhanced immunogenicity of peptide epitopes displayed on filamentous bacteriophage. The V3 loop of HIV-1 gp120
11. Recognition of HIV-derived B and T cell epitopes displayed on filamentous phages
12. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
13. New vectors for peptide display on the surface of filamentous bacteriophage
14. Antigenicity of HIV-derived T helper determinants in the context of carrier recombinant proteins: Effect on T helper cell repertoire selection
15. Cytotoxic T-lymphocyte responses to HIV-1 reverse transcriptase
16. Simultaneous display of different peptides on the surface of filamentous bacteriophage
17. MHC-peptide binding: Dimers of cysteine-containing non-apeptides bind with high affinity to HLA-A2.1 class I molecules
18. A conditioned dendritic cell can be a temporal bridge between a CD4+ T- helper and a T-killer cell
19. Help for cytotoxic T-cell responses is mediated by CD40 signalling
20. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
21. Ligation of B7 with CD28/CTLA-4 on T cells results in CD40 ligand expression, interleukin-4 secretion and efficient help for antibody production by B cells
22. HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice
23. Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex
24. High resolution structures of HIV-1 RT from four RT-inhibitor complexes
25. Immunodominant epitope regions of HIV-1 reverse transcriptase: Correlations with HIV-1+ serum IgG inhibitory to polymerase activity and with disease progression