Control of airway smooth muscle tone: II-Pharmacology of relaxation

Respiratory Medicine

Volumn 94, Issue 6, 2000, Pages 519-528

  Thirstrup, S ^a  

^a DANISH MEDICINES AGENCY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BIMAKALIM; CALCIUM ION; CARBACHOL; CROMAKALIM; CYCLIC AMP; CYCLIC GMP; GUANOSINE TRIPHOSPHATE; GUANYLATE CYCLASE; HISTAMINE; ION CHANNEL; ISRADIPINE; LEMAKALIM; NITRIC OXIDE; PHOSPHODIESTERASE INHIBITOR; PINACIDIL; POTASSIUM ION; PROSTAGLANDIN F2 ALPHA; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ASTHMA; BREATHING MUSCLE; BRONCHODILATATION; CALCIUM CELL LEVEL; GUINEA PIG; HUMAN; MEMBRANE POLARIZATION AND DEPOLARIZATION; MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RESPIRATORY SYSTEM; REVIEW; SMOOTH MUSCLE RELAXATION; SMOOTH MUSCLE TONE;

EID: 0033873220     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1053/rmed.1999.0738     Document Type: Review

References (106)

1. International consensus report on diagnosis and treatment of asthma
2. Airway smooth muscle relaxation
3. β-Adrenoceptors, cAMP and airway smooth muscle relaxation: Challenges to the dogma
4. Molecular mechanisms of β-adrenergic relaxation of airway smooth muscle
5. Electrophysiological and other aspects of the relaxant action of isoprenaline in guinea-pig isolated trachealis
6. Effects of relaxants on electrical and mechanical activities in the guinea-pig tracheal muscle
7. + -channel activity in tracheal myocytes by phosphorylation
8. Stimulatory and inhibitory regulation of calcium-activated potassium channels by guanine nucleotide-binding proteins
9. b-adrenergic agonists regulate K(Ca) channels in airway smooth muscle by cAMP-dependent and -independent mechanism
10. + channel inhibitor
11. Interaction of iberiotoxin with β-adrenoceptor agonists and sodium nitroprusside on guinea pig trachea
12. + channels in the relaxant action of vasoactive intestinal peptide and atrial natriuretic peptide in isolated guinea-pig tracheab
13. + channel blockers
14. Role of potassium channels in bronchodilator responses in human airways
15. + channel activation
16. Potassium channels in Airways
17. Inhibition of histamine-stimulated inositol phospholipid hydrolysis by agents which increase cyclic AMP levels in bovine tracheal smooth muscle
18. + ATPase activity in airway relaxation induced by salbutamol
19. Adrenergic receptor-coupled adenylyl cyclase systems: Regulation of receptor function by phosphorylation, sequestration and downregulation
20. β-adrenergic bronchodilators
21. Beta-adrenergic receptor kinase: Identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor
22. Differences in asthma management around the world
23. 2-agonists in the treatment of asthma
24. 2-agonists in Adults
25. Tolerance with β-agonists - A clinical problem?
26. 2-agonists
27. β-agonists: What is the evidence that their use increases the risk of asthma morbidity and mortality?
28. Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma
29. Comparison of the relative airways and systemic potencies of inhaled fenoterol and salbutamol in asthmatic patients
30. Partial vs full β-receptor agonism. A clinical study of inhaled albuterol and fenoterol
31. Comparison of the relative efficacy of formoterol and salmeterol in asthmatic patients
32. Vasoactive intestinal polypeptide in the respiratory tract
33. Neuropeptides as regulators of airway function: Vasoactive intestinal peptide and the tachykinins
34. Pharmacology of cotransmission in the autonomic nervous system: Integrative aspects on amines, neuropeptides, adenosine triphosphate, amino acids and nitric oxide
35. Vasoactive intestinal peptide causes bronchodilatation and protects against histamine-induced bronchoconstriction in asthmatic subjects
36. The effect of inhaled vasoactive intestinal peptide on bronchial reactivity to histamine in humans
37. Vasoactive intestinal peptide as a bronchodilator in severe asthma
38. Protease inhibitors potentiate smooth muscle relaxation induced by vasoactive nitestinal peptide in isolated human bronchi
39. Epithelium removal and peptidase inhibition enhance relaxation of human airways to vasoactive intestinal peptide
40. 1999 Receptor and Ion Channel Nomenclature Supplement. Trends Pharmacol Sci
41. Vasoactive intestinal polypeptide promotes cyclic adenosine 3', 5'-monophosphate accumulation in guinea-pig trachea
42. Effects of phosphodiesterase inhibitors on vasoactive intestinal peptide-induced relaxation of isolated guinea-pig trachea
43. Stimulation of sodium pump by vasoactive intestinal peptide in guinea-pig isolated trachea: Potential contribution to mechanisms underlying relaxation of smooth muscle
44. + channels in arterial smooth muscle
45. Absence of immunoreactive vasoactive intestinal polypeptide in tissue from the lungs of patients with asthma
46. Low plasma concentrations of VIP and elevated levels of other neuropeptides during exacerbations of asthma
47. Neuropeptide content of lungs from asthmatic and nonasthmatic patients
48. Responses of plasma vasoactive intestinal polypeptide to methacholine and exercise loading in children and adolescents with bronchial asthma
49. Atrial natriuretic factor receptors and signal transduction mechanisms
50. 1997 Receptor and Ion Channel Nomenclature Supplement
51. Regulation of adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'-monosphosphate levels and contractility in bovine tracheal smooth muscle
52. ANP relaxes bovine tracheal smooth muscle and increases cGMP
53. Nitric oxide inhibits calcium release from sacroplasmatic reticulum of porcine tracheal smooth muscle cells
54. Mechanism of atrial natriuretic polypeptide and sodium nitroprusside-induced relaxation in guinea-pig tracheal smooth muscle
55. Relationship between cyclic guanosine monophosphate accumulation and relaxation of canine trachealis induced by nitrovasodilators
56. K(Ca) channel antagonists reduce NO donor-mediated relaxation of vascular and tracheal smooth muscle
57. + channel in the relaxation of bovine tracheal smooth muscle by glyceryl trinitrate and sodium nitroprusside
58. + channels in porcine tracheal smooth muscle cells
59. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle
60. 2+ in cGMP-induced relaxation of guinea-pig trachea
61. Bronchodilator and pre-protective effects of urodilatin in bovine bronchi in vitro: Comparison with atrial natriuretic peptide
62. The L-arginine-nitric oxide pathway
63. The biology of nitrogen oxides in the airways
64. Airborne nitric oxide: Inflammatory marker and aerocrine messenger in man
65. Nitric oxide and asthmatic inflammation
66. Inhalation of nitric oxide modulates adult human bronchial tone
67. Bronchodilator effect of inhaled nitric oxide in healthy men
68. Clinical applications of nitric oxide
69. Atrial natriuretic factor (ANF) is a potent bronchodilator in asthma
70. Influence of elevated plasma levels of atrial natriuretic factor on bronchial reactivity in asthma
71. Effect of inhaled atrial natriuretic peptide on methacholine induced bronchoconstriction in asthma
72. High dose inhaled atrial natriuretic peptide is a bronchodilator in asthmatic subjects
73. Phosphodiesterase isoenzymes-molecular targets for new antiasthma agents
74. Identification, characterization and functional role of phosphodiesterase isozymes in human airway smooth muscle
75. Human bronchial cyclic nucleotide phosphodiesterase isoenzymes: Biochemical and pharmacological analysis using selective inhibitors
76. Cyclic nucleotide phosphodiesterase isoenzymes in guinea-pig tracheal muscle and bronchorelaxation by alkylxanthines
77. Effects of phosphodiesterase inhibitors on normal and chemically-skinned isolated airway smooth muscle
78. Relaxation of guinea-pig trachea by cyclic AMP phosphodiesterase inhibitors and their enhancement by sodium nitroprusside
79. Mechanical and electrical aspects of the relaxant action of aminophylline in guinea-pig isolated trachealis
80. Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus
81. Comparison of the effects of selective inhibitors of phosphodiesterase types III and IV in airway smooth muscle with differing beta-adrenoceptor subtypes
82. Effects of rolipram and siguazodan on the human isolated bronchus and their interaction with isoprenaline and sodium nitroprusside
83. Interaction between prostaglandins and selective phosphodiesterase inhibitors in isolated guinea-pig trachea in vitro
84. Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes
85. Phosphodiesterase (PDE)4 inhibitors: Anti-inflammatory drugs of the future?
86. Immunomodulatory actions of xanthines and isoenzyme selective phosphodiesterase inhibitors
87. Bronchodilators: New drugs and controversies
88. Bronchodilatory effect of inhaled zardaverine, a phosphodiesterase III and IV inhibitor, in patients with asthma
89. Effects of five different organic calcium antagonists on guinea- pig isolated trachea
90. 2+ antagonists in guinea-pig tracheal preparations contracted by potassium or carbachol
91. Clinical studies with calcium antagonists in asthma
92. Calcium channel blockade and asthma-the current position
93. + channel openers and other airway smooth muscle relaxants in isolated guinea-pig trachea
94. Effects of pinacidil on guinea-pig airway smooth muscle contracted by asthma mediators
95. Electrical and mechanical effects of BRL34915 in guinea-pig isolated trachealis
96. Mechanical, biochemical and electrophysiological studies of RP 49356 and cromakalim in guinea-pig and bovine trachealis muscle
97. Evaluation of the potassium channel activator cromakalim (BRL 34915) as a bronchodilator in the guinea-pig: Comparison with nifedipine
98. Cromakalim-induced relaxation of guinea-pig isolated trachealis: Antagonism by glibenclamide and by phentolamine
99. Glibenclamide blocks the relaxant action of pinacidil and cromakalim in airway smooth muscle
100. The action of a potassium channel activator, BRL 38227 (lemakalim), on human airway smooth muscle
101. Direct action of BRL 38227 and glibenclamide on intracellular calcium stores in cultured airway smooth muscle of rabbit
102. + channel openers produce epithelium-dependent relaxation of the guinea-pig trachea
103. Attenuation of nocturnal asthma by cromakalim
104. Effect of an oral potassium channel activator, BRL 38227, on airway function and responsiveness in asthmatic patients: Comparison with oral salbutamol
105. The lack of bronchodilator effect and the short-term safety of cumulative single doses of an inhaled potassium channel opener (bimakalim) in adult patients with mild to moderate bronchial asthma
106. + channel openers and suppression of airway hyperreactivity