In vitro and in vivo effects of 2'-deoxycoformycin (Pentostatin) on tumour cells from human γδ+ T-cell malignancies

British Journal of Haematology

Volumn 110, Issue 1, 2000, Pages 188-196

  Aldinucci, Donatella ^a   Poletto, Dalisa ^a   Zagonel, Vittorina ^a   Rupolo, Maurizio ^a   Degan, Massimo ^a   Nanni, Paola ^a   Gattei, Valter ^a   Pinto, Antonio ^a  

^a CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

Author keywords

2' deoxycoformycin; Cytotoxic effects; Haematological response; Hepatosplenic + T cell lymphomas; Pentostatin

Indexed keywords

DEOXYADENOSINE; PENTOSTATIN;

ADULT; ARTICLE; CASE REPORT; CLONOGENIC ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS; DOSE RESPONSE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; T CELL LYMPHOMA; TUMOR CELL;

ADENOSINE DEAMINASE; ADULT; ENZYME INHIBITORS; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; LIVER NEOPLASMS; LYMPHOMA, T-CELL; MALE; MIDDLE AGED; PENTOSTATIN; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SPLENIC NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0033872032     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.02129.x     Document Type: Article

References (39)

1. Tight-binding inhibitors. IV. Inhibition of adenosine deaminase by various inhibitors
2. Preferential localisation of human lymphocytes bearing the gamma delta T-cell receptor to the red pulp of the spleen
3. Pentostatin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in lymphoproliferative disorders
4. DNA strand breaks induced in human T-lymphocytes by the combination of deoxyadenosine and deoxycoformycin
5. Differential sensitivity of human leukemic T-cell lines and B-cell lines to growth inhibition by deoxyadenosine
6. Clinical experience with 2'-deoxycoformicin
7. Peripheral T-cell and NK-cell neoplasms: An integrated approach to diagnosis
8. New prospects in the treatment of indolent lymphomas with purine analogues
9. Clinical development of 2'-deoxycoformycin
10. Deoxyadenosine triphosphates as a potentially toxic metabolite in adenosine deaminase deficiency
11. Hepatosplenic T-cell lymphoma: A distinct clinicopathologic entity of cytotoxic γδ T-cell origin
12. Phase II trial of Pentostatin in refractory lymphomas and cutaneous T-cell disease
13. Deoxycoformycin in the treatment of mature T-cell leukaemias
14. Sentinel function of broadly reactive human gd T-cells
15. Distribution of T cells bearing different forms of the T cell receptor γ/δ in normal and pathological human tissues
16. Hepatosplenic T-cell lymphoma: Sinusal/sinusoidal localization of malignant cells expressing the T-cell receptor γδ
17. Human granulocyte-macrophage colony-stimulating factor supports the clonogenic growth of B-lineage acute lymphoblastic leukemias expressing myeloid antigens
18. The RET receptor tyrosine kinase, but not its specific ligand, GDNF, is preferentially expressed by acute leukaemias of monocytic phenotype and is up-regulated upon differentiation
19. Peripheral T-cell lymphoma presenting as a predominant liver disease: A report of three cases
20. Expression of the alpha/beta and gamma/delta T-cell receptors in 57 cases of peripheral T-cell lymphomas. Identification of a subset of gamma/delta T-cell lymphomas
21. Gamma/delta cells
22. A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group
23. Pentostatin in T-cell malignancies - A phase II trial of the EORTC
24. World Health Organization classification of neoplastic diseases of the hemopoietic and lymphoid tissues. A progress report
25. Phase I/II evaluation of Pentostatin (2'-deoxycoformycin) in a five day schedule for the treatment of relapsed/refractory B-cell chronic lymphocytic leukemia
26. Deoxycoformycin-induced response in chronic lymphocytic leukemia: Deoxyadenosine toxicity in non-replicating lymphocytes
27. Post transplant CD8+ γδ T-cell lymphoma associated with human herpesvirus-6 infection
28. Hepatosplenic T-cell lymphoma: An unusual case of a γδ T-cell lymphoma with a blast-like terminal transformation
29. The role of Pentostatin in the treatment of T-cell malignancies: Analysis of response rate in 145 patients according to disease subtype
30. Pentostatin (2'-deoxycoformycin, dCF) in patients with low-grade (B-T-cell) and intermediate- and high-grade (T-cell) malignant lymphomas: Phase II study of the EORTC Early Clinical Trials Group
31. The structure and function of CD26 in the T-cell immune response
32. Selective toxicity of purine nucleosides to human leukaemic cells
33. Inhibition of the self-renewal capacity of blast progenitors from acute myeloblastic leukemia patients by site-selective 8-chloroadenosine 3',5'-cyclic monophosphate
34. CD26 Expression and dipeptidyl peptidase IV activity in an aggressive hepatosplenic T-cell lymphoma
35. Potential use of purine nucleosides and enzyme inhibitors for selective depletion of Thy-lymphoblasts from human bone marrow
36. Hepatosplenic γδ T-cell lymphoma: Ultrastructural, immunophenotypic, and functional evidence for a cytotoxic T lymphocyte differentiation
37. Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes
38. Hepatosplenic γδ T-cell lymphoma. A distinctive aggressive lymphoma type
39. In vitro and in vivo effect of deoxycoformycin in human T cell leukemia