Catastrophic antiphospholipid syndrome

Current Opinion in Hematology

Volumn 7, Issue 5, 2000, Pages 325-329

  Asherson, Ronald A ^a   Cervera, Ricard ^b  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b HOSPITAL CLÍNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTICOAGULANT AGENT; CARDIOLIPIN ANTIBODY; CORTICOSTEROID; CYCLOPHOSPHAMIDE; DEFIBROTIDE; FIBRINOLYTIC AGENT; HEPARIN; LUPUS ANTICOAGULANT; METHYLPREDNISOLONE; TISSUE PLASMINOGEN ACTIVATOR; WARFARIN;

ANTIPHOSPHOLIPID SYNDROME; ARTERY THROMBOSIS; BLEEDING; BLOOD TRANSFUSION; CLINICAL FEATURE; DRUG EFFICACY; FETUS WASTAGE; HEMOLYSIS; HUMAN; INFECTION; INJURY; MULTIPLE ORGAN FAILURE; PATHOPHYSIOLOGY; PLASMAPHERESIS; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; THROMBOCYTOPENIA; THROMBOTIC THROMBOCYTOPENIC PURPURA; VEIN THROMBOSIS;

ANTIPHOSPHOLIPID SYNDROME; CATASTROPHIC ILLNESS; HUMANS; MICROCIRCULATION; MULTIPLE ORGAN FAILURE; THROMBOSIS;

EID: 0033870350     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-200009000-00012     Document Type: Review

References (13)

1. 1 Asherson RA: The catastrophic antiphospholipid syndrome. J Rheumatol 1992, 19:508-512.
2. 2 Asherson RA, Cervera R, Piette J-C, et al.: The "catastrophic" antiphospholipid syndrome. Clinical and laboratory features of 50 patients. Medicine 1998, 77:195-207.
3. 3 Kane D, McSweeney, Swan N, et al.: Catastrophic antiphospholipid antibody syndrome in primary systemic sclerosis. J Rheumatol 1998, 25:810-812.
4. 4 Asherson RA: The pathogenesis of catastrophic antiphospholipid syndrome. J Clin Rheumatol 1999, 5:242-252.
5. 5 Kitchens CS: Thrombotic storm: when thrombosis begets thrombosis. Am J Med 1998, 104:381-385.
6. 6 Rojas-Rodriguez J, Garcia-Carrasco M, Ramos-Casals M, et al.: Catastrophic antiphospholipid syndrome. Clinical description and triggering factors in eight patients. J Rheumatol 2000, 27:238-240. Six of eight patients in this report developed CAPS after infections (Streptococcus in three, Staphylococcus in two, Mycoplasma in one, and E. coli plus Staphyhcoccus in one).
7. 7 Hayem G, Kassis N, Nicaise P, et al.: Systemic lupus erythematosus-associated catastrophic antiphospholipid syndrome occurring after typhoid fever. A possible role of Salmonella lipopolysaccharide in the occurrence of diffuse vasculopathy-coagulopathy. Arthritis Rheum 1999, 42:1056-1061. This is a unique case of CAPS occurring after successful treatment of S. typhi infection.
8. 8 Undas-Swadzba J, Undas R, Musial J: Three episodes of acute multi-organ failure in a women with secondary antiphospholipid syndrome. Pol Arch Med WEWN 1998, 100:556-560.
9. 9 Asherson RA, Shoenfeld Y: The role of infection in the pathogenesis of catastrophic antiphospholipid syndrome-molecular mimicry? J Rheumatol 2000, 27:12-14. Possible pathogenic factors in production of CAPS are reviewed extensively. These include infections, the "clotting hypothesis," and a possible role of von Willebrand factor cleaving protease (as yet unproven).
10. 10 Gharavi AE, Pierangeli SS: Origin of antiphospholipid antibodies: induction of aPL by viral peptides. Lupus 1998, 7(suppl):S52-S54.
11. 11 Moake JL, Moschowitz E: Multimers and metalloproteases. N Engl J Med 1998, 339:1629-1631.
12. 12 Carey MJ, Rodgers GM: Disseminated intravascular coagulation: clinical and laboratory aspects. Am J Haematol 1998, 59:65-73.
13. 13 Cerveny KC, Sawitzke AD: Relapsing catastrophic antiphospholipid antibody syndrome: a mimic for thrombocytopenic purpura. Lupus 1999, 8:477-481.