Clenbuterol increases the expression of myogenin but not myoD in immobilized rat muscles

American Journal of Physiology - Endocrinology and Metabolism

Volumn 272, Issue 5 35-5, 1997, Pages

  Delday, M I ^a   Maltin, C A ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

atrophy; disuse; gene expression; growth; myogenic regulatory factors

Indexed keywords

CLENBUTEROL; MYOD PROTEIN; MYOGENIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; HINDLIMB; IMMOBILIZATION; MALE; MUSCLE ATROPHY; NONHUMAN; ORAL DRUG ADMINISTRATION; PLANTARIS MUSCLE; PRIORITY JOURNAL; RAT;

EID: 0030987276     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1997.272.5.e941     Document Type: Article

References (27)

1. Apseloff, G., B. Girten, M. Walker, D. R. Shepard, M. E. Krecic, L. S. Stern, and N. Gerber. Aminohydroxybutane bisphosphonate and clenbuterol prevent bone changes and retard muscle atrophy respectively in tail suspended rats. J. Pharmacol. Exp. Ther. 264: 1071-1078, 1993.
2. Asher, O., W. A. Kues, V. Witzemann, S. J. Tzartos, S. Fuchs, and M. C. Souroujonet. Increased gene-expression of acetylcholine-receptor and myogenic factors in passively transferred experimental autoimmune myasthenia gravis. J. Immunol. 151: 6442-6450, 1993.
3. Babij, P., and F. W. Booth. Clenbuterol prevents or inhibits loss of specific mRNAs in atrophying rat skeletal muscle. Am. J. Physiol. 254 (Cell Physiol. 23): C657-C660, 1988.
4. Baker, J. H., and D. E. Matsumoto. Adaptation of skeletal muscle to immobilisation in a shortened position. Muscle Nerve 11: 231-244, 1988.
5. Booth, F. W. Effect of limb immobilization on skeletal muscle. J. Appl. Physiol. 52: 1113-1118, 1982.
6. Booth, F. W., and P. D. Gollnick. Effects of disuse on the structure and function of skeletal muscle. Med. Sci. Sports Exercise 15: 415-420, 1983.
7. Carter, W. J., A. Q. Dang, F. H. Faas, and M. E. Lynch. Effects of clenbuterol on skeletal muscle mass, body composition and recovery from surgical stress in senescent rats. Metabolism 40: 855-860, 1991.
8. Chomczynski, P., and N. Sacchi. Single step method of RNA isolation by guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
9. Choo, J. J., M. A. Horan, R. A. Little, and N. J. Rothwell. Muscle wasting associated with endotoxemia in the rat: modification by the β-adrenoceptor agonist clenbuterol. Biosci. Rep. 9: 615-621, 1989.
10. Costelli, P., C. Garcia-Martinez, M. Llovera, N. Carbo, F. J. Lopez-Soriano, N. Agell, L. Tessitore, F. M. Baccino, and J. M. Argiles. Muscle protein waste in tumor-bearing rats is effectively antagonised by a β-adrenergic agonist (clenbuterol). J. Clin. Invest. 95: 2367-2372, 1995.
11. Eftimie, R., H. R. Brenner, and A. Buonanno. Myogenin and myoD join a family of skeletal muscle genes regulated by electrical activity. Proc. Natl. Acad. Sci. USA 88: 1349-1353, 1991.
12. Goldspink, D. F. The influence of immobilisation and stretch on protein turnover of rat skeletal muscle. J. Physiol. (Lond.) 264: 267-282, 1977.
13. Hayes, V. Y., P. J. Jackson, M. Fabrazzo, P. Follesa, and I. Mocchetti. Induction of nerve growth factor and basic fibroblast growth factor mRNA following clenbuterol: contrasting anatomical and cellular localization. Exp. Neurol. 132: 33-41, 1995.
14. Hollyoak, M. A., M. J. Muller, N. A. Meyers, W. G. Williams, R. E. Barrow, and D. A. Herndon. Beneficial wound healing and metabolic effects of clenbuterol in burned and non-burned rats. J. Burn Care Rehabil. 16: 233-240, 1995.
15. Kvetnansky, R., K. Fukuhara, K. Pacak, G. Cizza, D. S. Goldstein, and I. J. Kopin. Endogenous glucocorticoids restrain catecholamine synthesis and release at rest and during immobilisation stress in rats. Endocrinology 133: 1411-1419, 1993.
16. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. Protein measurement with the Folin reagent. J. Biol. Chem. 193: 265-272, 1951.
17. Maltin, C. A., M. I. Delday, G. P. Campbell, and J. E. Hesketh. Clenbuterol mimics effects of innervation on myogenic regulatory factor expression. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E176-E178, 1993.
18. Maltin, C. A., M. I. Delday, J. S. Watson, S. D. Heys, I. M. Nevison, I. K. Ritchie, and P. H. Gibson. Clenbuterol, a β-adrenoceptor agonist, increases relative muscle strength in orthopaedic patients. Clin. Sci. Lond. 84: 651-654, 1993.
19. Maltin, C. A., S. M. Hay, D. N. McMillan, and M. I. Delday. Tissue specific responses to clenbuterol: temporal changes in protein metabolism of striated muscle and visceral tissues from rats. Growth Reg. 2: 161-166, 1992.
20. Maltin, C. A., P. J. Reeds, M. I. Delday, S. M. Hay, F. G. Smith, and G. E. Lobley. Inhibition and reversal of denervation-induced atrophy by the β-agonist growth promoter, clenbuterol. Biosci. Rep. 6: 811-818, 1986.
21. Martineau, L., R. A. Little, N. J. Rothwell, and M. I. Fisher. Clenbuterol, a β-adrenergic agonist, reverses muscle wasting due to scald injury in the rat. Burns 19: 26-34, 1993.
22. Munro, H. M., and A. Fleck. Analysis of tissues and body fluids for nitrogenous compounds. In: Mammalian Protein Metabolism, edited by H. Munro. San Diego, CA: Academic, 1970, vol. 3, p. 424-525.
23. Pullar, J. D., and A. J. F. Webster. The energy cost of fat and protein deposition in the rat. Br. J. Nutr. 37: 355-363, 1977.
24. Sziklai, I., and J. Grof. Effect of immobilisation by plastering on the level of various energy metabolites in skeletal muscle. Acta Physiol. Acad. Sci. Hung. 59: 227-234, 1982.
25. Witzeman, V., and B. Sakmann. Differential regulation of myoD and myogenin levels by nerve induced muscle activity. FEBS Lett. 282: 259-264, 1991.
26. Zeman, R. J., A. Hirschman, M. L. Hirschman, G. Guo, and J. D. Etlinger. Clenbuterol, a β2-receptor agonist, reduces net bone loss in denervated hindlimbs. Am. J. Physiol. 261 (Endocrinol. Metab. 24): E285-E289, 1991.
27. Zeman, R. J., R. Ludemann, and J. D. Etlinger. Clenbuterol, a β2-agonist, retards atrophy in denervated muscles. Am. J. Physiol. 252 (Endocrinol. Metab. 15): E152-E155, 1987.